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Brain tumor growth linked to lowered expression of hundreds of immune function genes
Date:4/26/2010

examined.

There were, however, immune function genes whose expression increased with CD133 expression, including a cytokine gene called interleukin-17 that is linked to inflammation, and a gene related to suppression of immune function called NCAM-1.

The genes whose function was lowered with tumor progression included most of those associated with allergies, as well as, paradoxically, many of those that counteract allergy genes. In another surprising finding, many genes known to suppress immune function were also expressed at lower levels as the tumor progressed.

"That was a surprise because you'd think that genes that suppress the immune system would be more active in these tumors, which may be lethal, in part, because they are immunosuppressive. But we didn't see that," Schwartzbaum said.

Schwartzbaum is planning to focus her subsequent research on the end products of genetic activation, immune function proteins or cytokines.

She plans to analyze 1,200 samples from the Janus Serum Bank in Norway, which were collected on average 10 years before brain tumor diagnosis, to find out whether the presence of certain cytokines in those samples might offer clues that will help identify people at high risk for brain tumor development.


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Contact: Judith Schwartzbaum
schwartzbaum.1@osu.edu
614-293-3878
Ohio State University
Source:Eurekalert

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