Navigation Links
Brain study offers insight into causes of autism

Scientists are a step closer to understanding how abnormalities in brain development might lead to autism and behavioural disorders.

Research into Fragile X Syndrome a genetic condition that is the leading known cause of autism has discovered that critical phases in the brain's development may be mistimed in people with the condition.

The mistiming of key developmental stages may result in inappropriate communication between brain cells and could cause the symptoms experienced by Fragile X patients, such as hypersensitivity to touch and sound, as well as social withdrawal, hyperactivity and anxiety.

The study also found these changes in the brain's connections occur much earlier than previously thought, midway through a baby's development in the womb.

Scientists say that the study, published in the journal Neuron, suggests there are key "windows" when treatments for Fragile X and autism could be most effective.

Fragile X syndrome is as common as cystic fibrosis it affects around one in 4000 males and one in 8000 females worldwide. It causes intellectual disability as well as social, language and behavioural problems.

The research, conducted by scientists at Northwestern University in the USA and the University of Edinburgh, sought to identify ways in which the brains of people with Fragile X differ from those of healthy people.

Researchers used a mouse model of the condition to investigate how the regions of the brain responsible for processing sensory information for example, touch may develop differently in Fragile X patients.

The team believes that the changes they found in this area of the brain may be mirrored in other regions, explaining the range of symptoms experienced by people with Fragile X syndrome.

Professor Peter Kind, who led the study at the University of Edinburgh, said: "This research is important because it indicates when changes take place in the brains of Fragile X mice, which can be accurately projected to humans with Fragile X syndrome. We've learned these changes happen much earlier than previously thought, which gives valuable insight into when we should begin therapeutic intervention for people with these conditions. It also has implications for the treatment of autism since the changes in the brains of Fragile X and autistic people are thought to significantly overlap."


Contact: Anna Borthwick
University of Edinburgh

Related biology news :

1. Invasion of the brain tumors
2. HIV is a double hit to the brain
3. AIDS interferes with stem cells in the brain
4. 60 second test could help early diagnosis of common brain diseases
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
8. Inside the brain of a crayfish
9. Specific brain protein required for nerve cell connections to form and function
10. Brains timing linked with timescales of the natural visual world
11. Adult brain can change, study confirms
Post Your Comments:
(Date:6/2/2016)... YORK , June 2, 2016   The Weather ... is announcing Watson Ads, an industry-first capability in which consumers ... by being able to ask questions via voice or text ... Marketers have long sought ... the consumer, that can be personal, relevant and valuable; and ...
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC , ... announced the opening of an IoT Center of Excellence ... and expand the development of embedded iris biometric applications. ... level of convenience and security with unmatched biometric accuracy, ... identity aside from DNA. EyeLock,s platform uses video technology ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... Lawrence, MA (PRWEB) , ... June 23, 2016 ... ... the Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research ... test platform of microbial tests introduced last year,” stated Bob Salter, Vice President ...
Breaking Biology Technology: