Navigation Links
Brain study offers insight into causes of autism
Date:2/11/2010

Scientists are a step closer to understanding how abnormalities in brain development might lead to autism and behavioural disorders.

Research into Fragile X Syndrome a genetic condition that is the leading known cause of autism has discovered that critical phases in the brain's development may be mistimed in people with the condition.

The mistiming of key developmental stages may result in inappropriate communication between brain cells and could cause the symptoms experienced by Fragile X patients, such as hypersensitivity to touch and sound, as well as social withdrawal, hyperactivity and anxiety.

The study also found these changes in the brain's connections occur much earlier than previously thought, midway through a baby's development in the womb.

Scientists say that the study, published in the journal Neuron, suggests there are key "windows" when treatments for Fragile X and autism could be most effective.

Fragile X syndrome is as common as cystic fibrosis it affects around one in 4000 males and one in 8000 females worldwide. It causes intellectual disability as well as social, language and behavioural problems.

The research, conducted by scientists at Northwestern University in the USA and the University of Edinburgh, sought to identify ways in which the brains of people with Fragile X differ from those of healthy people.

Researchers used a mouse model of the condition to investigate how the regions of the brain responsible for processing sensory information for example, touch may develop differently in Fragile X patients.

The team believes that the changes they found in this area of the brain may be mirrored in other regions, explaining the range of symptoms experienced by people with Fragile X syndrome.

Professor Peter Kind, who led the study at the University of Edinburgh, said: "This research is important because it indicates when changes take place in the brains of Fragile X mice, which can be accurately projected to humans with Fragile X syndrome. We've learned these changes happen much earlier than previously thought, which gives valuable insight into when we should begin therapeutic intervention for people with these conditions. It also has implications for the treatment of autism since the changes in the brains of Fragile X and autistic people are thought to significantly overlap."


'/>"/>

Contact: Anna Borthwick
anna.borthwick@ed.ac.uk
44-131-651-4400
University of Edinburgh
Source:Eurekalert

Related biology news :

1. Invasion of the brain tumors
2. HIV is a double hit to the brain
3. AIDS interferes with stem cells in the brain
4. 60 second test could help early diagnosis of common brain diseases
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
8. Inside the brain of a crayfish
9. Specific brain protein required for nerve cell connections to form and function
10. Brains timing linked with timescales of the natural visual world
11. Adult brain can change, study confirms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Brooklyn, NY (PRWEB) , ... June 24, 2016 , ... ... 15mm, machines such as the Cary 5000 and the 6000i models are higher end ... height is the height of the spectrophotometer’s light beam from the bottom of the ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: