Navigation Links
Brain structure adapts to environmental change
Date:6/13/2011

  • Hippocampus adapts to environmental stresses
  • Stockpiles neuronal stem cells under deprived conditions, produces more neurons under favorable conditions
  • Knowledge of how neural stem cells produce neurons could lead to potential treatment for neurodegenerative diseases such as Alzheimer's and Parkinson's

(NEW YORK, NY, June 13, 2011) Scientists have known for years that neurogenesis takes place throughout adulthood in the hippocampus of the mammalian brain. Now Columbia researchers have found that under stressful conditions, neural stem cells in the adult hippocampus can produce not only neurons, but also new stem cells. The brain stockpiles the neural stem cells, which later may produce neurons when conditions become favorable. This response to environmental conditions represents a novel form of brain plasticity. The findings were published online in Neuron on June 9, 2011.

The hippocampus is involved in memory, learning, and emotion. A research team led by Alex Dranovsky, MD, PhD, assistant professor of clinical psychiatry at Columbia University Medical Center and research scientist in the Division of Integrative Neuroscience at the New York State Psychiatric Institute/Columbia Psychiatry, compared the generation of neural stem cells and neurons in mice housed in isolation and in mice housed in enriched environments. They then used lineage studies, a technique that traces stem cells from their formation to their eventual differentiation into specific cell types, to see what proportion of neural stem cells produced neurons.

Deprived and enriched environments had opposite effects. The brains of the socially isolated mice accumulated neural stem cells but not neurons. The brains of mice housed in enriched environments produced far more neurons, but not more stem cells. The average mouse dentate gyrus, the area of the hippocampus where neurogenesis takes place, has about 500,000 neurons; the enriched enviro
'/>"/>

Contact: Ann Rae Jonas
arj2116@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Birdsong independent of brain size
2. Emerging research in brain connectivity reveals new understanding of neurological disorders
3. New neurons take 6 months or more to mature in non-human primate brain
4. Deciding to stay or go is a deep-seated brain function
5. Early light refines the brains circuitry for vision
6. Changes in brain circuitry play role in moral sensitivity as people grow up
7. Pitt team recreates brain cell networks with new view of activity behind memory formation
8. What doesnt kill the brain makes it stronger
9. High iron, copper levels block brain-cell DNA repair
10. Building brains: An introduction to neural development
11. Surprising findings from studies of spontaneous brain activity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... VALLEY, Calif., August 19, 2014 -- Bay Area Lyme ... diagnose and simple to cure, applauds new research published ... journal Ticks and Tick-borne Diseases . The ... Northwest California are active throughout the year, making the ... by researchers at California Department of Public Health (CDPH) ...
(Date:8/20/2014)... Ore. -- When are athletes who have suffered concussions ... Oregon study has found that high school athletes who ... 60 days experience a significant regression in their abilities ... The regression, as seen in changes in their balance ... 19 athletes. Ten of the 12 had returned to ...
(Date:8/20/2014)... During the past few years, Virginia Tech,s Wu Feng ... Microsoft grant from the "Computing in the Cloud" program, ... a $6 million award from the Air Force on ... from NSF and the National Institutes of Health on ... wove together the "parallel computing" aspects from each grant, ...
Breaking Biology News(10 mins):Lyme disease risk is year-round in Northwest California, according to new study 2Lyme disease risk is year-round in Northwest California, according to new study 3Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4
... also available in Chinese on EurekAlert! Chinese ... scientists have published new research that improves the survival and ... Hsiao Chang Chan, from the Chinese University of Hong Kong, ... differentiation has led to a variety of breakthroughs as stem ...
... and alcohol serve as gateway drugs, which people use ... to cocaine and other illicit substances; this progression is ... in Science Translational Medicine by Amir Levine, ... at Columbia University Medical Center provides the first molecular ...
... want to get a jump on the latest news in ... Graduate Student Research Day set for Nov. 9, 2011. ... an opportunity for the best and brightest graduate students to ... Students from Stevens Institute of Technology, Rutgers University ...
Cached Biology News:Reprogramming stem cells to a more basic form results in more effective transplant, study shows 2Nicotine primes brain for cocaine use: Molecular basis of gateway sequence of drug use 2NJIT grad students display work at 7th annual Research Day on Nov. 9 2
(Date:8/21/2014)... 21, 2014 On Wednesday of last week ... use Redox Signaling molecules, became available for purchase in Australia ... "The way that RENU 28 works is, if you think ... of the rate of cellular renewal within your body. If ... of that rate of cellular renewal. What RENU 28 does ...
(Date:8/20/2014)... of patented university inventions licensed to biotechnology firms ... commercialization. To open these roadblocks, the researchers suggest ... the discovery stage could lead to faster commercialization ... derived from discoveries made in university laboratories and ... during clinical trials, which have a high failure ...
(Date:8/20/2014)... time, chemists have succeeded in measuring vibrational motion of ... study reveals how vibration of a single molecule differs ... The study was performed at the University of California, ... of Jyvskyl works as a visiting fellow under professor ... The second team was lead by Professor Eric O. ...
(Date:8/20/2014)... High performance computing (HPC) will ... complete climate and Earth system model to address ... , Eight national laboratories, including Lawrence Livermore ... for Atmospheric Research, four academic institutions and one ... national laboratories include Argonne, Brookhaven, Lawrence Berkeley, Los ...
Breaking Biology Technology:RENU 28 Skin Care Now Available in Australia and New Zealand 2Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Seeing a molecule breathe 2New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3
... GeneGo, Inc., the leading systems biology tools company, ... curated pathway maps from GeneGo, Inc. for their ... www.millipore.com/pathways , the tool links Millipore,s cutting edge ... bioinformatics content to related biological pathways. These maps ...
... company Pharmaxis,(ASX: PXS; Nasdaq: PXSL ) today ... senior management team in the position of Chief Medical ... pharmacovigilance and,medical affairs. Clinical Operations will continue to ... Dr Fox has more than 15 ...
... Sirion Therapeutics, Inc., a privately held ophthalmic-focused biopharmaceutical ... an agreement with Advanced Vision Research, Inc. (AVR) ... AVR,s new MacuTrition(R) oral retinal nutritional supplement and ... gland therapy. AVR is a privately held ophthalmic ...
Cached Biology Technology:Millipore Launches an Interactive Biological Pathway Tool Using GeneGo's Manually Curated Pathway Maps 2Millipore Launches an Interactive Biological Pathway Tool Using GeneGo's Manually Curated Pathway Maps 3Pharmaxis Builds Senior Management Team 2Sirion Therapeutics Partners With Advanced Vision Research (TheraTears(R)) to Promote Products for Retinal and Meibomian Gland Health 2Sirion Therapeutics Partners With Advanced Vision Research (TheraTears(R)) to Promote Products for Retinal and Meibomian Gland Health 3
... monoclonal [198C679.2.1] to Presenilin 2 Alzheimer's ... of the disease carry mutations in the ... precursor protein (APP). These disease-linked mutations result ... of amyloid-beta (main component of amyloid deposits ...
Human Presenilin-2 NTF Affinity Purified Polyclonal Ab...
5-bromo-2'-deoxyuridine (BrdU) Cell Biology Cell Proliferation Bromodeoxyuridine (BrdU) and Related Products...
2'-Fluorine-CTP (2'-F-CTP) is readily incorporated into transcripts by T7 and SP6 R&DNA™ Polymerase and is available separately....
Biology Products: