Navigation Links
Brain-nourishing molecule may predict schizophrenia relapse
Date:10/15/2008

the future, if the study results point in that direction," says Dr. Pillai. He also studies an animal model that has many behavioral as well as neurochemical abnormalities similar to schizophrenia. He's shown the downstream signaling of BDNF, a key pathway in the regulation of the inhibitory neurotransmitter GABA, is not working well in these animals. "Now we are going to see how we can rectify the problem," says Dr. Pillai who wants to keep BDNF levels on a more even keel.

About a dozen older schizophrenia medications and a handful of new ones adjust the activity level of a variety of neurotransmitters in the brain, Dr. Pillai says. Animal studies have shown the drugs have a differing impact on BDNF as well. Most initially improve the level then, with time, levels decrease of this factor that is required for brain development as well as cell proliferation, migration, differentiation and survival.

In the normal adult brain, BDNF increases stem cell proliferation so the brain is better armed if something bad, like a stroke, happens. Trophic factors such as BDNF also induce anti-apoptotic mechanisms that keep cells from committing suicide when stressed by a lack of oxygen, for example. Exactly where BDNF comes from or what controls endogenous levels is still unclear. Exercise can increase BDNF levels. Two drugs currently on the market for other medical conditions erythropoietin for anemia and cysteamine for cystinosis can as well. Dr. Pillai hopes his laboratory studies of these drugs will soon result in an adjunct therapy that can help patients avoid devastating relapse. "Our aim is to bring BDNF levels back to normal." Dr. Pillai and colleagues already have shown in their animal studies that antipsychotic drugs do better boosting brain BDNF levels when administered along with any of the above drugs. He adds that both cysteamine and erythropoietin have been well studied for their potential to enhance cognitive function.

Schizophrenia
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Memory molecule stores memories in neocortex
2. Clemson scientists shed light on molecules in living cells
3. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
4. Botched production of insulin molecule may lead to diabetes
5. New molecules discovered that block cancer cells from modifying cell DNA
6. New technique reveals subtle force-induced changes in biomolecules conformation
7. NIH recognizes Clemson nanotechnology for molecule tracking
8. Curry-derived molecules might be too spicy for colorectal cancers
9. New book presents methods to poke and prod individual molecules
10. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
11. Rice scientists make breakthrough in single-molecule sensing
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brain-nourishing molecule may predict schizophrenia relapse
(Date:4/22/2014)... There are all sorts of signaling strategies in nature. ... tails; satin bowbirds build specialized stick structures, called bowers, ... European bitterling males show off bright nuptial coloration during ... to communicate with others. , ... profound fitness implications for individuals that are either signaling ...
(Date:4/22/2014)... Scientists from the Florida campus of The Scripps Research ... a critical but previously unknown role in learning and ... novel role for a protein known as RGS7, was ... , a publisher supported by the Howard Hughes Medical ... , "This is a critical building block that regulates ...
(Date:4/22/2014)... PETA International Science Consortium Ltd.,s nanotechnology expert will present ... nanomaterial hazard assessment" at the 7th International Nanotoxicology ... Antalya, Turkey. , Dr. Monita Sharma will outline ... US National Academy of Sciences, " Toxicity Testing in ... which recommends use of non-animal methods involving human cells ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3Scientists identify critical new protein complex involved in learning and memory 2
... conventional electrolysis techniques requires considerable amounts of electrical energy. ... a catalytic technique powered by sunlight a process ... it is the Earth,s major source of oxygen. ... could provide abundant new supplies of oxygen and, possibly ...
... Jamie Scott, a Simon Fraser University professor and Canada ... are getting a hefty financial boost in their efforts ... States National Institutes of Health (NIH) has awarded the ... effectiveness of a DNA-based vaccine that Marinieve Montero first ...
... -- When neutrons and simulation unite . . . ... of the cellular world, could become easier by uniting ... Biophysical Journal. A team led by Oak Ridge National ... computer simulation and a type of neutron analysis called ...
Cached Biology News:Scientists study the catalytic reactions used by plants to split oxygen from water 2Scientists study the catalytic reactions used by plants to split oxygen from water 3SFU HIV/AIDS vaccine research gets financial boost 2April 2012 story tips 2April 2012 story tips 3April 2012 story tips 4
(Date:1/15/2014)... A study has been launched to test whether ... could help to tackle the problem of obesity.  This unique ... surgery based in Stowmarket) and academics at University Campus Suffolk ... technology, which is inspired by equipment used to collect data ...
(Date:1/15/2014)... 2014 DTS Language Services, Inc . ... Portal for Life Science organizations who need document translations. ... matter of their documents in advance with a selection of ... of translations, often a critical factor in clinical and scientific ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that they ... Russian pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ... , Turkey and other members ... antibiotic for the treatment of bacterial infections including those ...
(Date:1/14/2014)...  3D Communications, a leading provider of strategic communications services to corporations ... in the United States and ... , JD, is returning to the firm,s Washington, D.C. ... after more than two years of service as Associate Commissioner for ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2
... Vasogen Inc.,(NASDAQ: VSGN ; TSX:VAS), today announced that ... from the Listing Qualifications Department of The NASDAQ,Stock ... of its common,stock had fallen below $1.00 for ... in compliance with Marketplace Rule 4310(c)(4),(the "Rule"). In ...
... 25 Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ) announced ... Market ("Nasdaq") stating that the Company is not in,compliance ... on the Nasdaq Global Market pursuant to Marketplace Rule ... dated April 22,2008, is a standard communication when the ...
... April 25 ,Renovis, Inc. (Nasdaq: RNVS ), ... Services have joined ISS/Risk Metrics and Glass Lewis,& ... the merger,agreement with Evotec AG (Frankfurt Stock Exchange: ... May 1, 2008. In the proposed merger,each share ...
Cached Biology Technology:Vasogen Receives NASDAQ Notification Related to Minimum Bid Price 2Vasogen Receives NASDAQ Notification Related to Minimum Bid Price 3Keryx Biopharmaceuticals Receives Nasdaq Notification 2Keryx Biopharmaceuticals Receives Nasdaq Notification 3Proxy Governance and Egan-Jones Recommend Renovis Shareholders Vote For Merger With Evotec 2Proxy Governance and Egan-Jones Recommend Renovis Shareholders Vote For Merger With Evotec 3
Blasticidin resistance gene (bsr), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... These 2800mL PYREX Fernbach-style culture flasks have ... the flask bottom to achieve maximal oxygen ... a large marking spot., A wide range ... bottles including:, Polypropylene colored caps for ...
...
... mouth PYREX Fernbach-style culture flasks have triple ... flask bottom to achieve maximal oxygen transfer ... have a Delong-style 38mm neck for use ... plastic closures see Nos. CLS2679638 or CLS2679738. ...
Biology Products: