Navigation Links
Brain-nourishing molecule may predict schizophrenia relapse
Date:10/15/2008

A factor that helps optimize brain formation and function may also provide clues about whether patients suffering with schizophrenia are headed toward relapse, researchers say.

Over the next two- and one-half years, they are regularly measuring levels of brain-derived neurotrophic factor, or BDNF, in the blood of patients with schizophrenia to see if the pattern of their rise and fall is a good indicator that patients are headed for trouble, say Medical College of Georgia researchers.

"If you had something that would give you a better inkling that somebody is going to get ill, that would be extraordinarily helpful," says Dr. Peter S. Buckley, schizophrenia specialist who chairs the Department of Psychiatry and Health Behavior in the MCG School of Medicine. "It's a little bit of a shot in the dark, but the payoff would be huge," he says of the study that piggybacks on another federally-funded study looking at whether injectable medicine, rather than tablets, can help deter relapses.

Not taking their medicines as prescribed is a big reason patients relapse but science has already shown that BDNF levels can start dropping even when they do, says Dr. Anilkumar R. Pillai, MCG neuroscientist who studies BDNF and other cell-nourishing trophic factors. That drop likely indicates the drug is becoming less effective and a relapse is imminent, the researchers say.

Decreased BDNF levels already have been associated with relapsing bipolar disease and depression, Dr. Buckley says. Dr. Pillai and others have shown that the BDNF levels in patients with schizophrenia are generally lower than in healthy individuals, an indicator of its importance in this disease, he says. BDNF levels may be even lower in patients when they relapse and go up, at least for a while, with treatment.

"Theoretically, at least, if you could know the point when BDNF levels start going down, you might change the treatmentthat's at least one approach for
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Memory molecule stores memories in neocortex
2. Clemson scientists shed light on molecules in living cells
3. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
4. Botched production of insulin molecule may lead to diabetes
5. New molecules discovered that block cancer cells from modifying cell DNA
6. New technique reveals subtle force-induced changes in biomolecules conformation
7. NIH recognizes Clemson nanotechnology for molecule tracking
8. Curry-derived molecules might be too spicy for colorectal cancers
9. New book presents methods to poke and prod individual molecules
10. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
11. Rice scientists make breakthrough in single-molecule sensing
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brain-nourishing molecule may predict schizophrenia relapse
(Date:8/29/2014)... news release is available in German . ... chemical signals between organisms is considered the oldest form ... interactions between conspecifics, for example, the sexual attraction between ... social responses and to coordinate reproductive behavior in males ... the University of the Algarve in Faro, Portugal, and ...
(Date:8/29/2014)... the Tibetan plateau -- the largest topographic anomaly above ... its profound effect on climate and its reflection of ... Bulletin , Katharine Huntington and colleagues employ a cutting-edge ... and fossil snail shells to investigate the uplift history ... Views range widely on the timing of surface uplift ...
(Date:8/28/2014)... that an expansion of marine protected areas is needed ... According to investigators from the Wildlife Conservation Society ... focused on saving the largest numbers of species, often ... and difficult-to-replace ecological functions. , Many vital ... species that also are food for millions of people. ...
Breaking Biology News(10 mins):Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... more than 30 researchers today gave a score to every ... world,s oceans, which showed the United States as being slightly ... leading concerns. The analysis, published in the journal ... 10 separate categories such as clean water, biodiversity, food provision, ...
... N.H., August 15, 2012 A new report by ... concludes that the climate of the Northeast has changed ... the effects of climate change on multiple aspects of ... and eastern Canada and concludes with recommendations on adaptive ...
... DNA sequencing is rapidly getting faster and cheaper, ... be able to use this information. In a contest ... the world are vying to interpret the DNA sequences ... a mystery—with the goal of establishing "best practices" for ...
Cached Biology News:Rating of ocean health shows 'room for improvement' 2Climate change effects, potential mitigation in Northeast forests subject of Forest Service Report 2Thirty teams compete to interpret three families' genomes 2Thirty teams compete to interpret three families' genomes 3Thirty teams compete to interpret three families' genomes 4Thirty teams compete to interpret three families' genomes 5
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and his ... to participate in an investigational study of donor stem ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ... current investigational study must be older than nine months, ...
(Date:8/29/2014)... Boston, MA (PRWEB) August 29, 2014 Due ... (FRC) last week, the Adult Stem Cell Technology Center, ... donations to support stem cell therapy research that might benefit ... adult stem cells for new stem cell technologies and therapeutic ... ALS Ice Bucket Challenge donors who wish not ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Intrinsic ... 13485:2003 certified, GAMP® 5 compliant imaging core lab, ... international Phase II clinical trial to assess a ... Throughout this trial, Intrinsic Imaging will provide comprehensive ... to, protocol and charter development, site qualification, site ...
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 Best ... products for the food processing industry, is asking industry ... side-by side comparison of the E2 soap they’re currently ... Sanitizing Foam Soap . Hand hygiene is critical ... the food processing environment. Six key criteria are identified ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2
... Dec 28 Thermo Fisher,Scientific Inc. (NYSE: TMO ... JPMorgan Healthcare Conference being held at the Westin St. ... on Monday, January,7, 2008, at 4:00 p.m. (PST)., ... Thermo,Fisher Scientific, will provide an overview of the company ...
... Perrigo Company,(Nasdaq: PRGO ; TASE) today ... U.S. Food and Drug Administration for its Abbreviated ... 5 and 10 mg., The product will ... comparable,to McNeil Consumer Healthcare,s Cetirizine Hydrochloride Tablets, 5 ...
... Raven ... merger, SOUTH SAN FRANCISCO, Calif., ... stockholders approved the proposed reverse split of its common stock by,a margin of ... permits VaxGen to reverse split its stock in a ratio of 4,5, or ...
Cached Biology Technology:Thermo Fisher Scientific to Present at the 26th Annual JPMorgan Healthcare Conference 2Perrigo Announces FDA Approval for Over-The-Counter Cetirizine Hydrochloride Tablets 2VaxGen Stockholders Overwhelmingly Approve Reverse Split Proposal 2VaxGen Stockholders Overwhelmingly Approve Reverse Split Proposal 3VaxGen Stockholders Overwhelmingly Approve Reverse Split Proposal 4
Rabbit polyclonal to ErbB 2 (phospho Y1248) ( Abpromise for all tested applications). entrezGeneID: 2064 SwissProtID: P04626...
The Microseal 384 plate positioner ensures precise positioning of Microseal 384-well plates in the x-, y-, and z-dimensions, for accurate automated liquid handling....
... thin foil heat sealing material is ... from a screw down heated lid), ... a useful method for sample retrieval. ... the existing seal. Ideal for compound ...
... Sight DS-U2 camera controller is the successor to ... to interface any of the cameras in the ... through a USB2.0 interface. The DS-U2 transmits information ... installation by equipping both hub and mass storage ...
Biology Products: