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Brain cell growth diminishes long before old age strikes, animal study shows
Date:10/15/2007

Even early in adulthood, aging begins to slow the mind's growth -- but it does not have to stop it altogether, suggests a Princeton University study on the brains of adult monkeys.

A team of neuroscientists has found that soon after marmoset monkeys reach adulthood, the rate at which new neural cells form in the hippocampus region of the animals' brains begins to decline. The hippocampus is associated with both learning and memory. While other research groups have made similar observations in the brains of rodents, this is the first time the decrease in new cell growth, known as neurogenesis, has been noted in a primate, the biological order that also includes apes and humans.

That the hippocampus shows such a decrease in neurogenesis long before the onset of old age would appear at first to be utterly bad news for the mind. However, team member Elizabeth Gould said the findings nevertheless were encouraging for several reasons, including the implication that researchers might one day find ways of stimulating the human brain to generate neural cells more rapidly at any point in life.

"Past theories have suggested that complex brains, like those in monkeys and humans, undergo no changes in brain structure once adulthood is reached," said Gould, a professor of psychology and co-director of the Program in Neuroscience. "These new findings, however, offer further evidence that the primate brain actually shows a remarkable amount of structural reorganization over time. It declines with age, but it does persist at a lower level. Whatever stimulates these changes can most likely be tapped into and enhanced."

Marmosets, which are found in Central and South America, reach sexual maturity around the age of 18 months, and commonly begin showing the telltale signs of old age -- such as dementia and arthritis -- around the age of 8 years. Gould's team examined the neural cell growth in 17 marmosets of both genders, all of which were be
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Contact: Chad Boutin
cboutin@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

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