Navigation Links
Brain building: Study shows brain growth tied to cell division in mouse embryos
Date:3/30/2009

How your brain grows might come down to how your cells divide. In the April 6 issue of the Journal of Cell Biology (JCB), Lake and Sokol report that mouse protein Vangl2 controls the asymmetrical cell division and developmental fate of progenitor neurons.

Vangl2 (aka Strabismus in flies) is a component of the PCP (planar cell polarity) pathway that is active in a variety of tissues and organisms. Mice that lack Vangl2 have a number of neurological defects including incomplete neural tube closure and reduced brain size.

Sokol and Lake wondered how Vangl2 might influence brain development. In the cerebral cortex, neurons are born from a pool of progenitor cells, and the time of their birth determines their fate. The research duo found that Vangl2-lacking mouse embryos had large numbers of early-born neurons and few remaining progenitor cells. This hinted that Vangl2-lacking neurons were differentiating prematurelya suspicion confirmed in vitro.

The progenitor pool is maintained by asymmetrical divisionone daughter cell becomes a neuron, the other self-renews. This fate asymmetry is thought to depend on the orientation of cell division, and the authors observed an increase in the number of symmetrically dividing progenitors in the brains of Vangl2-lacking mouse embryos. Also, Vangl2-lacking cells in culture showed symmetrical distribution of a spindle-orienting factor that in normal cells distributes asymmetrically.

Such similarities between Vangl2-lacking cells in vitro and in vivo will facilitate ongoing studies of the PCP pathway in neurogenesis.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. To fight drug addiction, UB researchers target the brain with nanoparticles
2. Researchers discover gene mutations that cause childhood brain cancer
3. ChemoBrain: How cancer therapies can affect your mind
4. New and unexpected mechanism identified how the brain responds to stress
5. Penn research team tests bedside monitoring of brain blood flow and metabolism in stroke victims
6. Researchers capture wave of brain activity linked to anticipation
7. Case Western Reserve researchers develop wireless activation of brain circuits
8. Singapore research organisations team up to advance drug discovery using brain tumor stem cells
9. Researchers shed new light on connection between brain and loneliness
10. GEN reports on strategies to overcome blood-brain barrier
11. Brain structure assists in immune response, according to Penn vet study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brain building: Study shows brain growth tied to cell division in mouse embryos
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
Breaking Biology News(10 mins):
(Date:6/27/2017)... ... June 27, 2017 , ... DuPont Pioneer (DuPont) and ERS ... the ERS patent portfolio covering CRISPR-Cas genome editing technology for all agricultural uses ... (IP) of the CRISPR-Cas technology from co-inventor and co-owner Emmanuelle Charpentier, Ph.D. ...
(Date:6/26/2017)... ... ... The Workgroup for Electronic Data Interchange (WEDI) , the nation’s leading nonprofit ... and a statutory advisor to the U.S. Department of Health and Human Services (HHS), ... Coordinator for Health Information Technology, will deliver the keynote at its 2017 Summer Forum ...
(Date:6/23/2017)... ... 2017 , ... RURO, Inc., a leading LIMS, RFID, LIS ... growing Laboratory Information System. , LimitLIS® version 3 is includes new features that ... customization options. Each of these has been “under the microscope” in recent months ...
(Date:6/23/2017)... , ... June 23, 2017 , ... ... model aircraft flying hobbyists, and the University Aviation Association (UAA), the unifying voice ... The UAS4STEM Collegiate Challenge will encourage teamwork, competition, and success through a STEM-based ...
Breaking Biology Technology: