Navigation Links
Brain building: Study shows brain growth tied to cell division in mouse embryos
Date:3/30/2009

How your brain grows might come down to how your cells divide. In the April 6 issue of the Journal of Cell Biology (JCB), Lake and Sokol report that mouse protein Vangl2 controls the asymmetrical cell division and developmental fate of progenitor neurons.

Vangl2 (aka Strabismus in flies) is a component of the PCP (planar cell polarity) pathway that is active in a variety of tissues and organisms. Mice that lack Vangl2 have a number of neurological defects including incomplete neural tube closure and reduced brain size.

Sokol and Lake wondered how Vangl2 might influence brain development. In the cerebral cortex, neurons are born from a pool of progenitor cells, and the time of their birth determines their fate. The research duo found that Vangl2-lacking mouse embryos had large numbers of early-born neurons and few remaining progenitor cells. This hinted that Vangl2-lacking neurons were differentiating prematurelya suspicion confirmed in vitro.

The progenitor pool is maintained by asymmetrical divisionone daughter cell becomes a neuron, the other self-renews. This fate asymmetry is thought to depend on the orientation of cell division, and the authors observed an increase in the number of symmetrically dividing progenitors in the brains of Vangl2-lacking mouse embryos. Also, Vangl2-lacking cells in culture showed symmetrical distribution of a spindle-orienting factor that in normal cells distributes asymmetrically.

Such similarities between Vangl2-lacking cells in vitro and in vivo will facilitate ongoing studies of the PCP pathway in neurogenesis.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. To fight drug addiction, UB researchers target the brain with nanoparticles
2. Researchers discover gene mutations that cause childhood brain cancer
3. ChemoBrain: How cancer therapies can affect your mind
4. New and unexpected mechanism identified how the brain responds to stress
5. Penn research team tests bedside monitoring of brain blood flow and metabolism in stroke victims
6. Researchers capture wave of brain activity linked to anticipation
7. Case Western Reserve researchers develop wireless activation of brain circuits
8. Singapore research organisations team up to advance drug discovery using brain tumor stem cells
9. Researchers shed new light on connection between brain and loneliness
10. GEN reports on strategies to overcome blood-brain barrier
11. Brain structure assists in immune response, according to Penn vet study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Brain building: Study shows brain growth tied to cell division in mouse embryos
(Date:6/9/2016)... leader in attendance control systems is proud to announce the introduction of fingerprint attendance ... the right employees are actually signing in, and to even control the opening of ... ... ... Photo - ...
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... today announced the launch of the Supplyframe Design Lab . Located in ... to explore the future of how hardware projects are designed, built and brought ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: