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Brain background to body mass
Date:12/14/2008

o carries all the risk variants would typically be 1.5-2 kg heavier than an average person. The findings of this study will pave the way for future investigations to uncover more of the elusive variants, perhaps through sequencing of whole genomes, which has become more efficient and cost-effective in the past year or so.

The research also helps to set the stage to unravel the two influences of genetics and environment. Future research could harness the power of longitudinal cohort studies, which track the health of many subjects through time, thereby providing the tools to map gene-environment interactions.

"As we uncover more variants, we will gain a better basic understanding of obesity, which in turn will open doors to previously unimagined areas of clinically relevant research," explains Joel Hirschhorn, Associate Professor of Genetics at Children's Hospital/Harvard Medical School and at the Broad Institute. "We hope that these advances will guide the development of more effective treatments and interventions."


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Contact: Don Powell
don@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

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