Navigation Links
Brain background to body mass
Date:12/14/2008

A genetic study of more than 90,000 people has identified six new genetic variants that are associated with increased Body Mass Index (BMI), the most commonly used measure of obesity. Five of the genes are known to be active in the brain, suggesting that many genetic variants implicated in obesity might affect behaviour, rather than the chemical processes of energy or fat metabolism.

Obesity is an increasing problem that results in individual risk to health as well as increasing burdens on health care systems. By identifying genetic variants that affect obesity, researchers hope to understand better the mechanisms regulating energy balance, which will guide the development of new therapies and help to develop improved diagnosis.

The study is published in Nature Genetics by the GIANT Consortium and includes authors from more than 60 institutions.

"It might seem remarkable that it is the brain that is most commonly influenced by genetic variation in obesity, rather than fat tissue or digestive processes," says Dr Ines Barroso, a senior author on the study, from the Wellcome Trust Sanger Institute. "Until 2007, no genetic associations had been found for 'common obesity', but today almost all those we have uncovered are likely to influence brain function."

Increase in weight occurs when calories taken in exceed calories burned, but behind that simple equation lie behavioural processes such as appetite and satiety, as well as the biochemical mechanisms our bodies use to process foods and use stores of energy, such as fat tissue. A part of the brain called the hypothalamus controls many of our basic functions such as body temperature, hunger and fluid balance: it is programmed to maintain the status quo.

"Very occasionally, mutations in genes active in the hypothalamus have dramatic consequences for weight gain," explains Dr Ruth Loos, a leading author from the Medical Research Council Epidemiology Unit, "such that
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Invasion of the brain tumors
2. HIV is a double hit to the brain
3. AIDS interferes with stem cells in the brain
4. 60 second test could help early diagnosis of common brain diseases
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
8. Inside the brain of a crayfish
9. Specific brain protein required for nerve cell connections to form and function
10. Brains timing linked with timescales of the natural visual world
11. Adult brain can change, study confirms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Bushmeat, the use of native animal species for food ... be a significant factor in the decline of many ... new study indicates that more than half of the ... raptors and hornbills., "By surveying not only the meat ... being eaten inside the forest by hunters and brought ...
(Date:7/24/2014)... identified two factors that characterize sustainable university and ... highly qualified physics teachers. Specifically, one or more ... education in combination with institutional motivation and commitment ... Technology, Engineering and Math (STEM) teacher shortages are ... the way for institutions seeking to increase the ...
(Date:7/24/2014)... sticky research out of York University shows a surprisingly ... toxic grass fungus: moose saliva (yes moose saliva). ... "Ungulate saliva inhibits a grassendophyte mutualism" shows that moose ... (which hosts a fungus called epichlo festucae that produces ... less toxicity. , "Plants have evolved defense mechanisms to ...
Breaking Biology News(10 mins):Creating sustainable STEM teacher preparation programs 2Moose drool inhibits growth of toxic fungus: York U research 2
... New research published in the August 2005 issue ... methamphetamine abuse and HIV infection cause significant alterations ... in both cases the changes may be associated ... learning new information, solving problems, maintaining attention and ...
... in our bodies through a complex network of lymphatic ... however, of major importance for the support of the ... from the Flanders Interuniversity Institute for Biotechnology (VIB) connected ... to indicate that this network can be studied with ...
... of voices they hear to the number of faces ... The finding indicates that numerical perception is truly an ... particular sense, said the researchers. The experimental approach also ... before they have a verbal capacity, understand similar abstract ...
Cached Biology News:Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure 2Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure 3Tadpole soon to help in the fight against cancer and lymphedema 2Tadpole soon to help in the fight against cancer and lymphedema 3Monkeys understand numbers across senses 2
(Date:7/24/2014)... Livermore, California (PRWEB) July 24, 2014 ... due to advances in modeling lithium-ion battery storage ... could benefit from a theoretical model created at ... Rice University that predicts how carbon components ... for energy storage emphasizes the urgent need for ...
(Date:7/24/2014)... Francisco, CA (PRWEB) July 24, 2014 ... to be semi-finalists in Livestrong’s Big C Competition. Out ... Health are each headed to the semi-final round. In ... Livestrong’s exclusive three-month accelerator program, complete with mentoring from ... , As part of the angelMD commitment to ...
(Date:7/24/2014)... 24, 2014 WIRB-Copernicus Group ® ... ethical review services for clinical research, announced today ... division of Richmond, VA -based ... and biosecurity consulting firm in the ... biosafety division – WCG Biosafety™ – will be ...
(Date:7/24/2014)... 2014 Draper University, a top ... to announce that for 6 weeks this summer, ... converge on the Draper University campus in the ... program focused on entrepreneurship, building real-world skills, and ... running its sixth cohort, continues to refresh its ...
Breaking Biology Technology:Getting More Life out of Lithium-ion Batteries 23 angelMD Startups Make Livestrong Big C Semi-finals 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3
... Md. , May 18 OriGene Technologies, Inc. with the ... build one of the largest and most sophisticated monoclonal antibody production centers ... production facility is expected to have over one thousand employees with the ... , , ...
... The ... of genetics and molecular biology rapidly expands, a personalized approach to medical care is ... ... set to revolutionize the healthcare industry. As our knowledge of genetics and molecular biology ...
... , ... Gilson, Inc. has selected EDL Consulting’s CloudCraze product to build an enterprise-class, cross-channel ... Built on the Force.com platform and utilizing EDL’s CloudCraze eCommerce product, the ... to customers across Europe. , ...
Cached Biology Technology:OriGene Technologies, Inc. to Build the World's Largest TrueMAB(TM) Monoclonal Antibody Facility in Wuxi, China 2Arrowhead Releases New Report Assessing State of Personalized Medicine Market 2Arrowhead Releases New Report Assessing State of Personalized Medicine Market 3Gilson, Inc. Selects EDL Consulting's CloudCraze For Cross-Channel Webstore Expansion in Europe 2Gilson, Inc. Selects EDL Consulting's CloudCraze For Cross-Channel Webstore Expansion in Europe 3
From formula-fed bovine calves Sterile, Cell culture tested...
... is a thermostable DNA polymerase derived ... at temperatures above 70°C, it was ... PCR and remains the predominant enzyme ... an intrinsic 5'?3' structure-dependent exonuclease activity, ...
Mouse monoclonal [YPF19] to Yersinia pestis F1 antigen ( Abpromise for all tested applications)....
... This high pressure gradient system uses ... pumps, each providing a flow rate in one ... wavelength detector for added flexibility. System control ... processing software and interface unit, CE 4900., Column ...
Biology Products: