Navigation Links
Brain abnormalities in Parkinson's patients develop before symptoms occur
Date:1/20/2010

Scientists who have identified brain networks damaged in Parkinson's disease have new evidence that these systems become abnormal a few years before symptoms appear. And what's more, parts of the network appear to respond in a last ditch attempt to rescue the brain.

"We were surprised," said Chris Tang, MD, PhD, a Parkinson's investigator at The Feinstein Institute for Medical Research in Manhasset, NY, and an author of the study, published this month in the Journal of Neuroscience. The Feinstein scientists have been following people with Parkinson's disease for decades. They have had a unique opportunity to take snapshots of the brain over the course of four years in 15 patients and an equal number of normal volunteers. The group initially identified two discrete abnormal networks, one that was involved in mediating the motor symptoms of Parkinson's disease, and the other that regulates the cognitive dysfunction that develops in many patients with this illness.

Symptoms of Parkinson's disease initially occur on one side of the body, which provided scientists with a unique opportunity to study the brain scans at multiple times and compare the symptoms to changes in the brain networks over time. The idea for the latest study was to watch the activity of the network on the side of the brain that controls the side of the body that's free of symptoms. As the disease progresses, both sides of the body ultimately become involved.

The motor network that governed the side of the body with initial symptoms was the first to become abnormal. Scientists under the direction of David Eidelberg, MD, head of the Feinstein's Center for Neurosciences, found that the motor network on the other side of the brain was also abnormal, even though symptoms appeared only two years later. The brain network that governs cognition began showing abnormalities after two more years had passed, which was four years after their diagnosis. The average age of the patients in the study is 58 and no one has yet to develop cognition problems.

The brain scans measure glucose and dopamine, the chemical that is depleted during the disease process. By using these scans to understand what the brain is doing before symptoms emerge, investigators are characterizing new therapeutic targets to slow or actually prevent the onset of clinical disability in Parkinson's disease and related neurological illnesses.


'/>"/>

Contact: Jamie Talan
jtalan@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Related biology news :

1. Invasion of the brain tumors
2. HIV is a double hit to the brain
3. AIDS interferes with stem cells in the brain
4. 60 second test could help early diagnosis of common brain diseases
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Influence of sex and handedness on brain is similar in capuchin monkeys and humans
8. Inside the brain of a crayfish
9. Specific brain protein required for nerve cell connections to form and function
10. Brains timing linked with timescales of the natural visual world
11. Adult brain can change, study confirms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... CA (PRWEB) , ... June 27, 2016 , ... ... for clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT ... care circle with the physician and clinical trial team. , Using the CONSULT module, ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... NC (PRWEB) , ... June 24, 2016 , ... Researchers ... the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are ... to read it now. , Diagnostic biomarkers are signposts in the blood, lung ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
Breaking Biology Technology: