Deepak C. D'Souza, M.D., of Yale University, Deepak C. D'Souza, M.D., of Yale University, is interested in the consequences of chronic cannabis exposure and schizophrenia. Evidence suggesting a link between marijuana use and psychosis has relied mostly on self-reporting. Participants in this study will be members of a group whose early, unrestricted use of cannabis is central to their beliefs. Preliminary data show that these subjects underperform non-cannabis using controls on cognitive tests and have higher measures of schizophrenia symptoms.
Stephen J. Glatt, Ph.D., of the State University of New York, will study a risk gene for schizophrenia, DRD2, which encodes receptors for the brain chemical dopamine. How variant forms of DRD2 impart susceptibility to schizophrenia remains unclear. Dr. Glatt is focused on answering that question to gain further insight of the underlying pathology of schizophrenia and to identify better targets for new medications and earlier interventions.
Christine I. Hooker, Ph.D., of Harvard University, hopes to improve the future of young people at risk for psychosis as it affects their cognitive skills. Research has shown that intensive cognitive and social skills training improve functioning in people with schizophrenia. In the proposed project, a group of youths at high risk will participate in a randomized trial of a computerized intervention targeting functions compromised in schizophrenia such as attention, memory and problem solving.
Oliver D. Howes, M.D., Ph.D., of King's College London, wants to determine whether changes in behavior of the brain chemic
|Contact: Sally Corbett|
Brain & Behavior Research Foundation