Navigation Links
Boy interrupted: Y-chromosome mutations reveal precariousness of male development
Date:9/2/2013

ransformation of female tissues into male tissues. From there, the testes develop and produce testosterone, which eventually forms the male's external genitalia.

The university's study employs mutated SRY genes shared by a father and a sterile XY daughter. Females usually develop with an XX pair, but, in these families, the father instead produced a daughter with an XY pair. This occurs during fetal development when the SRY gene's master switch fails to trigger. Internal female tissues, such as the uterus and fallopian tubes, continue to develop but are dysfunctional and infertile.

"Yet the father has the same Y chromosome and the same mutation as the daughter," Weiss pointed out. "And since he is a fertile male, we know that the switch must be poised right at its edge."

The team decided to measure the biochemical threshold of the SRY master switch.

"Our expectation was that we'd find that a factor of 100 or morea severe insult to the Y-encoded switchwas necessary to alter development," Weiss said. "But what we found was that the SRY threshold, as probed in father-daughter pairs, is only a factor of two."

Therefore, human males actually develop near the edge of sexual ambiguity. This means that, unlike the robust genetic programs which develop other essential processes like heart function, the SRY gene master switch is particularly vulnerable to change. It only takes a slight deviation from the normal process to dramatically alter fetal sexual development.

Given the importance of sexual reproduction to the survival of a species, why do human SRY genes function so close to the boundary of infertility? The idea of an unreliable master switch might appear paradoxical, but a growing body of research suggests that it might be an evolutionary necessity.

Extensive studies of gender-associated styles of childhood play and the acquisition of social competencies by Dr. S. Baron-Cohen and colleagues at Cambridge U
'/>"/>

Contact: Amanda Petrak
amanda.petrak@case.edu
216-368-0345
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BRG1 mutations confer resistance to hormones in lung cancer
2. Gene mutations cause massive brain asymmetry
3. Interacting mutations promote diversity
4. Mutations in autism susceptibility gene increase risk in boys
5. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
6. New gene mutations linked to ALS and nerve cell growth dysfunction
7. Key mutations discovered for most common childhood brain cancer
8. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
9. Gene mutations linked to most cases of rare disorder -- Alternating Hemoplegia of Childhood
10. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
11. Populations survive despite many deleterious mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... have shown the potential for global climate change to ... most part, ignored the interactions between increasing temperature and ... to damage crops. , A new study involving researchers ... significant, suggesting that policymakers need to take both warming ... , The study looked in detail at global production ...
(Date:7/27/2014)... single computer cannot always find the solution a user ... cluster of computers that analyze a massive data set ... history to present you with targeted ads, and how ... movie. But big data is about more than just ... are generating unprecedented quantities of information. That data may ...
(Date:7/25/2014)... first broad-scale estimate of air pollution removal by trees ... trees are saving more than 850 human lives a ... , While trees, pollution removal equated to an average ... impacts of that improvement are substantial. Researchers valued the ... nearly $7 billion every year in a study published ...
Breaking Biology News(10 mins):Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5First national study finds trees saving lives, reducing respiratory problems 2
... Bad drivers may in part have their genes to blame, ... a particular gene variant performed more than 20 percent worse on ... test a few days later yielded similar results. About 30 percent ... from the get-go, and they forget more of what they learned ...
... OCTOBER 27, 2009 -- The 2009 Annual Meetings of ... of America (CSSA), and Soil Science Society of America ... Pittsburgh, PA. The meeting,s theme, "Footprints in the Landscape: ... location in the LEED-certified David L. Lawrence Convention Center ...
... WHAT: DigitalPersona Vice President of Marketing, Jim ... the Industry Expert Panel on Endpoint Security. Discussing the ... Fulton will describe how enterprises can address security vulnerabilities ... examine how the implementation of identity-aware security offerings shifts ...
Cached Biology News:Bad driving may have genetic basis, UCI study finds 22009 Annual Meetings emphasize sustainability 2DigitalPersona to Speak at Dallas SecureWorld Expo 2
(Date:7/28/2014)... The National Model Aviation Museum, located at ... to announce that it has been granted full civilian ... States Air Force. , The certification is the culmination ... spring with an on-site inspection by Sarah Sessions, Museum ... National Museum of the United States Air Force ...
(Date:7/25/2014)... study by researchers from the University of Leicester ... function, unlocking the potential to create new materials ... has been published in the prestigious academic journal ... laser technique to examine in rich detail the ... cluster containing an acetylene molecule and a single ...
(Date:7/25/2014)... California (PRWEB) July 25, 2014 Lawrence ... named to Thomson Reuters list of " The World's ... are part of the 3,000 researchers who were identified ... to recognize those who published the highest-impact work (2002-2012 ... research papers on combustion modeling . , "This ...
(Date:7/24/2014)... -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the ... Phase 3 study of Zerenex (ferric citrate), the Company,s ... of hyperphosphatemia in patients with end-stage renal disease (ESRD) ... delivery with FErric CiTrate in EsrD) was published online ... of Nephrology ( JASN ). , ...
Breaking Biology Technology:AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4
... Ariz., May 31, 2011 Regal One Corporation (OTCBB:RONE), ... on incubating and bringing public high quality companies, today ... shares of Rampart Detection Systems Ltd Common stock. Regal ... registration statement with the United States Securities and Exchange ...
... Pharmaceuticals, Inc. (Nasdaq: AMLN ) will be presenting at ... 7, 2011, at 12:20 p.m. ET / 9:20 a.m. ... Global Life Sciences Conference on Wednesday, June 8, 2011, at 10:00 ... New York.  Daniel M. Bradbury, president and chief executive ...
... RALEIGH, N.C., May 31, 2011 Today, Campbell Alliance released ... latest in its Landmark Study series.  A summary report of ... the firm is sharing a more in-depth presentation of the ... Study explores the factors that have caused major changes in ...
Cached Biology Technology:Regal One Announces Dividend of Rampart Detection Systems Common Stock 2Oncology National Commercial (ONC) Study Outlines 10 Trends Shaping the Market for Oncology Pharmaceutical and Biotech Products 2
... is an 18 amino acid synthetic peptide whose sequence corresponds to ... peptide is (amino to carboxy terminus): M(1) - A - S ... A - S - P - R - D - A ... peptide may be used for neutralization and control experiments with the ...
... Hollandes is a fixative useful for routine ... It is stable and will decalcify small ... Hollande's can be stained successfully with most ... solution stabilizes red blood cell membranes and ...
... Hollandes is a fixative useful for ... fixation. It is stable and will decalcify ... with Hollande's can be stained successfully with ... the solution stabilizes red blood cell membranes ...
Chicken polyclonal antibody to Glutathione-S-Transfrease (GST)...
Biology Products: