Navigation Links
Boy interrupted: Y-chromosome mutations reveal precariousness of male development
Date:9/2/2013

The idea that men and women are fundamentally different from each other is widely accepted. And throughout the world, this has created distinct ideas about which social and physical characteristics are necessary in each gender to maintain healthy human development.

However, social revolutions throughout the last century have challenged traditional ideas about not only which traits are normal and necessary for survival, but also how humans acquire them. Thanks to a new study from researchers at Case Western Reserve University, science is continuing the charge.

By studying rare families in which a daughter shares the same Y chromosome as her father, Michael Weiss, MD, PhD, and his colleagues at the university's School of Medicine have determined that the pathway for male sexual development is not as consistent and robust as scientists have always assumed.

A team led by Weiss, chairman of the Department of Biochemistry, the Cowan-Blum Professor of Cancer Research, and a professor of biochemistry and medicine, has published a study in the Proceedings of the National Academy of Sciences that examines the function of the SRY gene. This gene is responsible for initiating the process that leads to male development.

"A general principle of developmental biology is that evolution favors reliability," Weiss explained. "Robust switches ensure that our genetic programs give rise to a consistent body plan to ensure that babies have one heart, two arms, ten fingers, and so forth."

Traditional viewpoints emphasize the uniformity of this process. The new research indicates that male sexual development is less stable than other genetic programs.

In fetal development, a gene located on the Y chromosome, called SRY, begins the process that leads to male development. All fetuses initially develop with female tissues, no matter what the sex will be at birth, so the master switch is responsible for initiating the t
'/>"/>

Contact: Amanda Petrak
amanda.petrak@case.edu
216-368-0345
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BRG1 mutations confer resistance to hormones in lung cancer
2. Gene mutations cause massive brain asymmetry
3. Interacting mutations promote diversity
4. Mutations in autism susceptibility gene increase risk in boys
5. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
6. New gene mutations linked to ALS and nerve cell growth dysfunction
7. Key mutations discovered for most common childhood brain cancer
8. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
9. Gene mutations linked to most cases of rare disorder -- Alternating Hemoplegia of Childhood
10. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
11. Populations survive despite many deleterious mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/st5b3m/saudi_arabia ) ... Biomedical Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Saudi Arabia Biomedical Sensors market is estimated at $0.23 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
(Date:8/25/2015)... BELLEVUE, Wash. , Aug. 25, 2015  Sarcos ... today it will unveil its "Guardian S" snake robot, ... National Tactical Officers Association Conference on August 30 in ... is the first-ever commercially available energetically autonomous snake robot, ... in-field trials and is protected by more than 50 ...
(Date:8/20/2015)... 20, 2015 The wearable technology market ... active and healthy. However, wearable technology has the ... to help improve diagnostic capabilities and therapeutic outcomes. ... Wearable Technologies Conference 2015 , where ... wearables in healthcare.    "Over the ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3
... scientists at the Broad Institute of MIT and Harvard announced ... that can connect human diseases with potential drugs to treat ... human cells. Called the "Connectivity Map," the new tool and ... Science and in separate publications in the September 28 immediate ...
... your way through an unfamiliar neighborhood to a friend's ... is adept at adapting. It can make decisions based ... new information. , The nature of such sophisticated decision ... high-level processing, has been "poorly studied and little understood," ...
... sequence of a 5-million-year-old retrovirus and shown that it is ... ancestor of a large family of mobile DNA elements, some ... study, which is the first to generate an infectious retrovirus ... a breakthrough for the field of retrovirus research. The ...
Cached Biology News:Genetic 'roadmap' charts links between drugs and human disease 2Genetic 'roadmap' charts links between drugs and human disease 3Where we change our mind 2Scientists resuscitate a 5 million-year-old retrovirus 2
(Date:8/28/2015)... ... ... initial launch of FireflySci Inc. (FFS) in early 2015, the company continues to shake up ... the Fonz in a lab coat and Large Marge have been posted on the company’s ... , FireflySci is proud to be the only cuvette manufacturer is the world that has ...
(Date:8/27/2015)... 27, 2015  Neogen Corporation (NASDAQ: NEOG ) ... United Kingdom -based Lab M Holdings, ... and diagnostic systems. Lab M was ... provider of microbial testing and diagnostic products for the ... company currently sells into more than 70 countries worldwide, ...
(Date:8/27/2015)...  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a leading ... today announced that executives from the company will present ... , Pedro Lichtinger , Chief ... Annual Global Investment Conference on Wednesday, September 10, 2015 ... in New York City . ...
(Date:8/27/2015)... 2015 GlassesOff (OTCBB: GLSO), a visual ... the human vision system, announced today a partnership with eight-time ... Chris Paul to develop a new mobile app designed ... their real-life on-court performance. Vision is the inception ... shooting a ball or blocking a pass. The critical impact ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Neogen acquires U.K.-based Lab M Holdings 2Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3
... 2, 2011 /PRNewswire-Asia/ -- ShangPharma Corporation (NYSE: ... pharmaceutical and biotechnology research and development outsourcing company, today ... for the fourth quarter and full year 2010 ended ... host a conference call to discuss the results at ...
... – EMD Serono, Inc., an affiliate of Merck ... a complete response letter (CRL) from the U.S. ... drug application (NDA) for Cladribine Tablets, EMD Serono,s ... therapy for relapsing-remitting multiple sclerosis (MS). ...
... Communications , the team have created a microscope which shatters ... beating the diffraction limit of light. Previously, the standard ... 0.001 millimetres clearly. But now, by combining an ... the Manchester researchers can see 20 times smaller 50 ...
Cached Biology Technology:ShangPharma Corp. to Announce Fourth Quarter and Full Year 2010 Financial Results on March 15, 2011 2EMD Serono Receives Complete Response Letter From FDA on Cladribine Tablets New Drug Application 2EMD Serono Receives Complete Response Letter From FDA on Cladribine Tablets New Drug Application 3EMD Serono Receives Complete Response Letter From FDA on Cladribine Tablets New Drug Application 4Microscope could 'solve the cause of viruses' 2