Navigation Links
Bovine genome provides clues to possible new developments
Date:4/23/2009

Scientists from Texas AgriLife Research and the Texas A&M University College of Veterinary Medicine & Biomedical Sciences (CVM) are part of a consortium of researchers who have developed an annotated sequence of the cattle genome which could lead to better disease resistance and higher quality meat for consumers, the researchers say. Their work was led by the Baylor College of Medicine Human Genome Sequencing Center and published in two reports that appear today in the journal "Science."

The researchers used the complete sequence from a single Hereford cow and comparative genome sequences for six more breeds, looking for changes called single nucleotide polymorphisms SNPs markers that can help researchers identify favorable traits.

"The biggest thing that came out of the SNP project was the resource of the SNPs themselves," said Dr. Clare Gill, a Texas AgriLife Research beef geneticist who co-led the SNP initiative. "That has changed how we operate when we do DNA studies and identification of genes."

Texas AgriLife Research is part of the Texas A&M University System, with scientists based at Texas A&M in College Station and 13 research centers across the state.

SNPs in 497 cattle from 17 geographically and biologically diverse breeds and two related species (anoa and water buffalo) were used in the project. Using SNPs, Gill said there could be considerable progress made in cattle health as well as meat production.

"There could be progress made in disease resistance, production efficiency, tenderness and marbling," Gill said.

Dr. James Womack, who holds the title of Distinguished Professor in the CVM and has studied the bovine genome for the past 20 years and is one of the team leaders of the project, said the work "opens the door to look at all sorts of specific interests in cattle from disease immunity to better meat quality, better milk production and on and on."

"Ten to 20 years down the line, this will lead to new avenues in cattle research that were not available to us previously," Womack says. "It's a huge step in the field of cattle research."

His colleague in much of the work was Dr. Loren Skow, also a faculty member in the CVM.

Gill hosted the DNA repository from cattle around the world. Gill is using the SNP resources generated in this study to tie information into the agency's own cattle mapping resource at the AgriLife Research Center in McGregor.

Gill also led a team that annotated the genes detailed in "Science" and received contributions from students in her applied animal genomics graduate-level course. Contributing to the research were graduate students Carl Muntean, Cody Gladney, Natasha Romero and Jungwoo Choi. Undergraduates Clayton Boldt and Jennifer Chapin contributed annotations, as well as Kris Wunderlich (doctoral candidate) and Colette Abbey (research associate). AgriLife Research scientists Drs. Penny Riggs and Tom Welsh also contributed to the annotation process.

Womack said the cattle sequence took six years to complete, annotate and analyze with more than 300 scientists from 25 countries. Most of more than 25 companion reports describing detailed analyses of the two projects by the Bovine Sequencing Project and the Bovine Hapmap Consortia appear online at www.biomedcentral.com in a special electronic issue of the BioMed Central journal group.

"The future challenge will be to explore the bovine genome sequence in greater depth to fully understand the genetic basis of the evolutionary success of ruminants as this will provide opportunities to address some of the crucial issues of the present time efficient and sustainable food production for a rapidly increasing human population," said Dr. Richard Gibbs, director of the BCM Human Genome Sequencing Center and principal investigator on the project.

The authors concluded that the bovine genome, consisting of at least 22,000 genes, is more similar to that of humans than that of mice or rats. They note that most cattle chromosomes correspond to part or all of human chromosomes, although the DNA is rearranged in some areas.


'/>"/>

Contact: Blair Fannin
b-fannin@tamu.edu
979-845-2259
Texas A&M University
Source:Eurekalert

Related biology news :

1. Research leading to tools for managing bovine respiratory disease complex
2. Veterinary college researchers explore function of biofilm in bovine respiratory disease
3. Unravelling new complexity in the genome
4. Conquest of land began in shark genome
5. One species entire genome discovered inside anothers
6. Genome study shines light on genetic link to height
7. First individual genome sequence published
8. Ultraconserved elements in the genome: Are they indispensable?
9. $10 million gift to support cutting-edge epigenome center at USC
10. Fungus genome yielding answers to protect grains, people and animals
11. Which came first, the chicken genome or the egg genome?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , April 28, 2016 Infosys ... (NYSE: INFY ), and Samsung SDS, a global ... that will provide end customers with a more secure, fast ...      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... but it also plays a fundamental part in enabling and ...
(Date:4/26/2016)... DUBLIN , April 27, 2016 ... of the  "Global Multi-modal Biometrics Market 2016-2020"  report ... ) , The analysts forecast ... a CAGR of 15.49% during the period 2016-2020.  ... a number of sectors such as the healthcare, ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)... Ky. , June 23, 2016 ... two Phase 1 clinical trials of its complement ... placebo-controlled, single and multiple ascending dose studies designed ... pharmacodynamics (PD) of subcutaneous injection in healthy adult ... subcutaneously (SC) either as a single dose (ranging ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
Breaking Biology Technology: