Navigation Links
Botched production of insulin molecule may lead to diabetes
Date:10/1/2007

ANN ARBOR, Mich. Picture a pretzel factory production line, with conveyer belts carrying the dough, formed into unbaked pretzels, down to the oven to be cooked.

Now imagine what would happen if pretzel dough started to overflow the mixer and oozed as a blob onto the conveyor, misshapen, and sticking fast to the dough of the other fully formed, unbaked pretzels. The result: a mess. And if that mess could no longer be conveyed into the oven, the backup of messy dough in the system would get worse and worse, and might eventually shut down the whole factory.

Thats essentially what might be happening in a much smaller kind of factory: the cells that make insulin in the body of people with diabetes.

According to new findings by a team from the University of Michigan Medical School, those tiny factories may shut down because of glitches in the production of a molecule called proinsulin the precursor, or dough, out of which insulin is made.

The insulin factories are called beta cells, and they normally churn out large quantities of insulin within the pancreas. This insulin supply can be released into the bloodstream as needed, to help the body turn sugars from food into energy for cells.

But in people with diabetes, the beta cell factories dont keep up with the demand for insulin, and sugar builds up in the blood, wreaking havoc on nerves, blood vessel walls and kidneys. And just like a factory that cant fill a growing number of orders for a hot product, the situation just keeps getting worse and the diabetes progresses.

Scientists have been working to understand why insulin production falters in people with diabetes, and the U-M team has focused on the production and folding of the proinsulin molecule deep within the beta cell. Using a tag that can make proinsulin glow green, they have now found a way to watch proinsulin being made within animal cells, and folded into a shape that can then be turned into in
'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers discover key gene involved in bark beetle pheromone production
2. First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
3. Mass production of human papillomavirus could lead to gains against cervical cancer
4. UW scientists report a new method to speed bird flu vaccine production
5. New cell transplantation technique restores insulin production in diabetics
6. New molecule may aid in production of biofuels and fungi-resistant plants
7. Getting an evolutionary handle on life after reproduction
8. Olfactory system detects pheromones that control reproduction
9. The brain is broadly wired for reproduction
10. Sexual reproduction delays aging in a mammalian species
11. Sustainable farm practices improve Third World food production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... that a single fungal cell or bacterial colony exerts on ... a heavy role in setting up some of the most ... be too much of a stretch to say that plants ... respond to the touch of beneficial fungi, according to a ... at the University of Wisconsin-Madison. , "Many people have ...
(Date:8/27/2014)... FREMONT, Calif. , Aug. 27, 2014  WaferGen ... completed its previously announced underwritten public offering of units ... $10,000 per unit for gross proceeds of $20 million, ... expenses payable by the Company.  The shares and warrants ... Each unit sold in the offering consists ...
(Date:8/27/2014)... North America,s megafauna mastodons, short-faced bears, giant ground ... disappeared close to 13,000 years ago at the end ... extinction has long been debated by scientists who, until ... group of scientists, including UC Santa Barbara,s James Kennett, ... that a comet collision with Earth played a major ...
Breaking Biology News(10 mins):A touching story: The ancient conversation between plants, fungi and bacteria 2A touching story: The ancient conversation between plants, fungi and bacteria 3WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Nanodiamonds are forever 2Nanodiamonds are forever 3
... December, 2010 Elsevier, the world-leading publisher of scientific, ... that it is participating in the recently launched Google ... eBook titles. Elsevier regards Google eBooks as a valuable ... its scientific and professional ebook content in the United ...
... (i.e., estrogen produced by ovaries and by other tissues) ... (HRT) utilizing estrogen alone (the exogenous estrogen) provides a ... study results presented at the 33rd Annual CTRC-AACR San ... "Our analysis suggests that, contrary to previous thinking, there ...
... without saying that conservatives and liberals don,t see the world ... Nebraska-Lincoln suggests that is exactly, and quite literally, the case. ... and conservatives, reaction to "gaze cues" a person,s ... person,s eye movements, even if it,s irrelevant to their current ...
Cached Biology News:Elsevier offers scientific book content through Google eBooks 2Estrogen alone is effective for reducing breast cancer risk 2Look: What your reaction to someone's eye movements says about your politics 2
(Date:8/28/2014)... BELLINGHAM, Washington, USA (PRWEB) August 27, 2014 ... Colorado next month for SPIE Laser Damage 2014 ... on optical materials for high-power lasers will run 14-17 ... international society for optics and photonics . , The ... key for understanding laser damage to optical materials will ...
(Date:8/28/2014)... 2014 A new market research ... is available from Strategic Consulting, Inc., the leading ... Microbiology Market Review, Fourth Edition: Global Review of ... tracks and compares microbiology test volumes, market values ... and Asia, and forecasts future volumes and market ...
(Date:8/28/2014)... Earlier this month, a report was created ... U.S. Air Force on the performance of vehicles using ... type of fuel made from mustard seeds, offered great ... America’s Eco friendly future. In fact, every branch of ... independent of foreign oil over the next few years. ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a ... SoundConnect to support their communication needs with ... web conferencing platform GlobalMeet powered by SoundConnect. The ... SoundConnect delivers award winning “results driven” business ... will be utilizing GlobalMeet powered by SoundConnect ...
Breaking Biology Technology:Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5PrimeSource Chooses SoundConnect as Collaboration Provider 2
... grounding in science is widely considered to be crucial ... and pharmacists to physician assistants and physical therapists, the ... the fields of healthcare and science. Yet, for the ... Interactive for University of the Sciences ( ...
... PharmAthene, Inc. (NYSE Amex: PIP ), a ... threats, announced today that it has completed a previously ... Company of approximately $6.5 million. Under the ... of 1,857,143 units to certain institutional investors for a ...
... Calif., June 15, 2011 Synthetic Genomics, Inc. (SGI), ... a variety of global needs including clean renewable energy, ... Mahler will join the company as Chief Financial Officer ... for leading and directing all financial aspect of the ...
Cached Biology Technology:Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 2Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 3Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 4PharmAthene Completes $6.5 Million Registered Direct Offering 2PharmAthene Completes $6.5 Million Registered Direct Offering 3Synthetic Genomics Inc. Appoints Joseph Mahler as Chief Financial Officer 2
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Goat polyclonal to BACE1 ( Abpromise for all tested applications). entrezGeneID: 23621 SwissProtID: P56817...
... Immunogen: Peptide ... encompassing the human, mouse, and ... Accession Number: NM_000314 ... Routinely evaluated by immunoblot. ...
Biology Products: