Navigation Links
Boston University researchers develop novel drug delivery system
Date:1/31/2012

BOSTON (1-31-12) -- Long duration, controllable drug delivery is of wide interest to medical researchers and clinicians, particularly those seeking to improve treatment for patients with chronic pain or to prevent cancer recurrence after surgery. Now a team of researchers led by Boston University Biomedical Engineer and Chemist Mark Grinstaff has developed a unique material and drug delivery mechanism that could pave the way for implants that release a drug at a designated rate for months.

The system consists of a biocompatible, highly porous, three-dimensional polymer material containing a selected drug and a volume of air that slows infiltration from surrounding water. As water seeps into the material, it displaces the air, gradually releasing the drug.

"The idea was to create a 3D material that has polymer fibers throughout and air trapped within," said Grinstaff, who developed the material in conjunction with BU biomedical engineering PhD student Stefan Yohe and Dr. Yolanda Colson, a Brigham and Women's Hospital thoracic surgeon and lung cancer specialist. "If we can slow the penetration of water into the structure, it will slow the release of the drug."

To prevent water from flooding the structure and causing an immediate release of the drug, Grinstaff and his colleagues designed the air-filled, mesh-like material to be "superhydrophobic"so water-resistant that droplets of water barely touch the surface, forming beads similar to those that appear on a freshly waxed car. They produced the porous polymer mesh using a process called electrospinning, which overlays micron-sized fibers upon one another.

To control the rate of drug release, they adjusted chemical and physical properties of the material so that the entrapped air is loosely or tightly held. The more tightly held the air is within the structure, the harder it is for water to displace it, the slower the release, and the longer the treatment duration.

Loaded with a widely used anti-cancer drug called SN-38 in in vitro experiments, the polymer mesh and internal air pocket proved to be robust and effective against lung cancer cells in solution for more than 60 days, indicating its suitability for long-term drug delivery. Grinstaff and his collaborators next plan to conduct a series of in vivo experiments to evaluate the system's efficiency and potential clinical effectivenessa critical preliminary step before initiating clinical trials.

Supported by the National Institutes of Health, The Wallace H. Coulter Foundation, the Center for Integration of Medicine & Innovative Technology and Boston University, this research was originally sparked by the Grinstaff group's ongoing investigation of potential therapies for recurring lung cancer, and interest in the use of new materials and procedures to deliver drugs over the course of months.

"Many researchers are advancing new drug delivery systems, and several others are designing superhydrophobic materials, but we're combining these disciplines to see if we can open up new doors and enable more effective treatments for a wide range of diseases," said Grinstaff.

The researchers detailed their novel drug delivery system in the January 16 online edition of the Journal of the American Chemical Society.


'/>"/>

Contact: Michael Seele
mseele@bu.edu
617-353-9766
Boston University College of Engineering
Source:Eurekalert

Related biology news :

1. Boston University School of Medicine researchers clarify link between salt and hypertension
2. Boston University School of Medicine professor honored by American College of Nutrition
3. Register now! Boston meeting will showcase latest aging discoveries
4. NIH training grant awarded to Boston University School of Medicine and College of Engineering
5. Join GSA in Boston for the nations premier aging conference
6. BU researchers identify extensive methane leaks under streets of Boston
7. Boston Medical Center receives support from CVS Caremark Charitable Trust
8. Boston Medical Center to receive $245,000 grant from Attorney General Martha Coakley
9. Boston Medical Center receives grant from Astrazeneca to end diabetes
10. Aetna Foundation funding Boston University obesity research
11. Boston Medical Centers CARE Unit receives additional NIH funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... Germany , March 9, 2016 ... country,s government identified that more than 23,000 public service ... or had been receiving their salary unlawfully.    ... African country,s government identified that more than 23,000 public ... name or had been receiving their salary unlawfully.    ...
(Date:3/8/2016)... 2016   Valencell , the leading innovator ... has secured $11M in Series D financing. The ... venture fund being launched by UAE-based financial services ... investors TDF Ventures and WSJ Joshua Fund. Valencell ... triple-digit growth and accelerate its pioneering innovation in ...
(Date:3/3/2016)... March 3, 2016  2016FLEX, organized by FlexTech, ... highlighting advancements in flexible, hybrid and printed electronics. ... attendance - have gathered for short courses, technical ... of electronics. The Flex Conference celebrates its 15 ... companies, R&D organizations, and universities contributing to the ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... , ... Global Stem Cells Group and the University of Santiago ... and development initiatives for potential stem cell protocol management for 2016 – 2020. ... began meeting to establish a working agenda and foster initiatives to promote stem cell ...
(Date:4/26/2016)... , ... April 27, 2016 , ... ... Lewis Roca Rothgerber Christie LLP as an associate in the firm’s Intellectual Property ... international electrical, mechanical and electromechanical patent applications. He has an electrical engineering and ...
(Date:4/26/2016)... (PRWEB) , ... April 26, 2016 , ... ... laser lithography systems, announces the latest technology innovation for its Volume Pattern Generator ... tomorrow’s demand for production of advanced photomasks as well as a solution for ...
(Date:4/26/2016)... MD (PRWEB) , ... April 26, 2016 , ... ... a $1.8M Series A round of financing. Healthy investor interest drove significant oversubscription ... portfolio of generic biologics, known as biosimilars, to the advanced preclinical stages. , Chief ...
Breaking Biology Technology: