Navigation Links
Boston University engineer to use $2.5 million NIH grant to cells' reaction to physical force
Date:9/23/2009

BOSTON (9-24-09) -- The National Institutes of Health today announced an award of $2.5 million to a team led by Boston University biomedical engineer Bela Suki that will study the role of physical forces on cell function, with the goal of understanding the possible roles of these forces in diseases like atherosclerosis, neuro-degenerative diseases, metabolic disorders, aging and cancer.

NIH today announced Suki's team among the winners of Transformative R01 grants, created to support exceptionally innovative, high-risk, original and/or conventional research projects that have the potential to create or overturn fundamental paradigms.

"We know that physical force plays a role in vascular disease and other ailments," Suki said. "Our research is aimed at understanding the scope of this impact using forces that more closely mimic those in nature."

Suki's team plans to lay cells on an elastic membrane and stretch them using a new method that randomly alters the magnitude and timing of each stretch as would happen naturally then study the effect on the cells' function.

Researchers have already documented a correlation between repeated stretching at regular intervals and altered cell function, and Suki's preliminary research on lung cells indicates a more dramatic cellular response when the stretching is varied. Suki's group observed significant changes in the secretion of a vital molecule that facilitates gas exchange in the lung when his method was used.

He plans to use the NIH grant to expand the research to include vascular endothelial and smooth muscle cells, as well as skin fibroblasts. If the researches observe effects on these cells similar to what Suki has seen in the lung cells, scientists and medical professionals may have to rethink their approach to mechano-biology.

Specifically, Suki's team will investigate the effect of variable stretching on transcription, translation and secretion of molecules like cytokines, enzymes and proteins, and how it influences basic cellular functions like division, growth and death. He will attempt to determine if there are universal mechanisms that govern cellular function among different organ systems.

"Uncovering how cells deal with such physiological variability may help understand how cells work in real living tissue, as well as the pathogenesis of several major diseases," he said.


'/>"/>

Contact: Mike Seele
mseele@bu.edu
617-353-9766
Boston University College of Engineering
Source:Eurekalert

Related biology news :

1. Boston University biomedical engineers teach bacteria to count
2. Boston College chemistry professor Udayan Mohanty receives a 2009 Guggenheim Fellowship
3. At Boston symposium, NARSAD researchers report on genes and family traits
4. Software developed by Boston College lab delivers speed and accuracy to genome research
5. Singapores BIOPOLIS and FUSIONOPOLIS on stage in Boston this week
6. DHS Begins Collecting 10 Fingerprints From International Visitors at Boston Logan International Airport
7. Boston College profs study oxidative stress subcellular to discover its role in diseases
8. Boston University biomedical engineers find chink in bacterias armor
9. Tel Aviv University invention busts dust
10. University of Iowa scientists use blood-brain barrier as therapy delivery system
11. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 2016 , ... Cancer experts from Austria, Hungary, Switzerland, and ... new and helpful biomarker for malignant pleural mesothelioma. Surviving Mesothelioma has just published ... , Biomarkers are components in the blood, tissue or body fluids that ...
(Date:6/27/2016)... Hill, N.C. (PRWEB) , ... June 27, 2016 ... ... U.S. commercial operations for Amgen, will join the faculty of the University ... serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a ...
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
Breaking Biology Technology: