Navigation Links
Boston University biomedical engineers find chink in bacteria's armor
Date:9/6/2007

yl radical damage, you can potentiate or enhance the lethality of bactericidal antibiotics. This highlights the value of taking a network biology approach to antibiotics and provides a framework for creating new classes of drugs, said Collins.

What we think is happening is the cell is getting a signal that says, Theres something wrong with our energy production system and we need to make more energy. But, theres really nothing wrong. The cell becomes confused, turns on too many processes at once and its overwhelmed, said Kohanski.

Previous work by Kohanski and co-lead author Dan Dwyer, a postdoctoral researcher in Collins lab, revealed the first hints that this underlying pathway exists. In studying bacterial response to a quinolone, an antibiotic that inhibits DNA replication, they noted a surprising change in genes responsible for energy production and iron uptake.

In the current study, the researchers used DNA microarray studies to see if all three classes of bactericidal antibiotics triggered this process. Across the board, they noted increased gene activity along the intracellular assembly lines that make energy for the bacterial cell, just as in the earlier study. They began to deduce the details of the new pathway.

Cells produce free superoxide radicals naturally in oxygen-rich environments, but when they unnecessarily ramp up energy production to a frantic pace such as when triggered by antibiotics more radicals get churned out than the cells safety measures can mop up. The superoxide radicals then pull iron from other components of the cell, and this iron rapidly stimulates production of toxic levels of hydroxyl radicals.

Its really amazing that despite the diversity of targets, you have everything funneling into this common pathway, where theres a global meltdown occurring, said Dwyer. Theres almost no way for the cell to recover from this. It shows you how potent these molecules are to damaging and killi
'/>"/>

Contact: Mike Seele
mseele@bu.edu
617-353-9766
Boston University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Boston University biomedical engineers win major grant for pursuit of the $1,000 Genome
2. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
3. New protein discovered by Hebrew University researchers
4. Next Generation Body Scanner Launched By The University Of Manchester
5. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
6. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
7. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
8. Carnegie Mellon University research reveals how cells process large genes
9. University of Delaware researchers develop cancer nanobomb
10. University of Arizona plant scientists to unravel maize genome
11. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ... Iris Recognition Market 2015-2019" report to their offering. ... market to grow at a CAGR of 23.5 percent ... the present scenario and the growth prospects of the ... calculate the market size, the report considers the revenue ...
(Date:3/24/2015)... 2015   NexID Biometrics LLC, whose spoof-mitigation ... today announced the beginning of shipments of version 2.0 ... The company, based in Potsdam, N.Y. ... Expo, which began here today at the Walter E. ... of its SDK boosts the accuracy rate range to ...
(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group ... NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one ... feedback on their experience with the Wocket in multiple scenarios ... CVS, Whole Foods and other retailers, making both debit and ... Tuttle also says, "If the company meets their plans ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... The Office of Naval Research (ONR) has announced 15 ... 2009 Young Investigator Program (YIP). "We serve ... in science, technology, engineering and mathematics," says Chief of ... initiatives like the Young Investigator Program, ONR is encouraging ...
... doubts that mothers especially pregnant mothers are ... benefits of exercise for these women and their developing ... exercise. A survey examining daily activities of moms-to-be will ... looking at the effect of maternal exercise on fetal ...
... Secondhand tobacco smoke and smoke from cooking oil ... women who were exposed to small doses of the ... a study from the University of Kentucky. The ... harm cardiovascular function. In addition, it extended those findings ...
Cached Biology News:ONR announces 2009 Young Investigator Award recipients 2Differences among exercisers and nonexercisers during pregnancy 2Differences among exercisers and nonexercisers during pregnancy 3Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive 2Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive 3
(Date:5/5/2015)... SAN DIEGO AND TORONTO, May 5, 2015 /PRNewswire/ - Aptose ... "Company") today reported financial results for the three months ... Unless specified otherwise, all amounts are in Canadian dollars. ... changed its fiscal year end from May 31 to ... current interim period being reported is for the three ...
(Date:5/5/2015)... 05, 2015 Research and Markets ... addition of the "Separation Systems Market ... Macromolecules which include protein, RNA, ... are broken into smaller molecules, during production ... requires various advanced systems like centrifugation, liquid ...
(Date:5/5/2015)... , May 5, 2015 Reprints Desk, Inc., ... providing on-demand access to scientific, technical and medical (STM) ... the Association of Southeastern Research Libraries (ASERL) . ... libraries located across 11 southeastern states. Founded in 1956, ... collaborative programs to address the continually changing needs of ...
(Date:5/5/2015)... , May 05, 2015 Research and ... the addition of the "Clinical Laboratory, Molecular ... Forecast 2015 to 2019 - Global Version" ... developments especially in the area of molecular diagnostics ... growing and evolving world market that is moving ...
Breaking Biology Technology:Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 2Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 3Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 4Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 5Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 6Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 7Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 8Global Separation Systems Market in Biotechnology 2015-2019 - Trends and Forecasts for the $28 Billion Market 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2
... , , , , , , ... , University Hospital and Medical School of the Dutch-speaking Brussels Free , ... , , , , , ... , Preimplantation diagnosis (PGD) is a very ...
... gradient , , , , , , , ... and Research, University , of Malaya, Kuala Lumpur, Malaysia , , , , ... , , ... , , ...
... , Ravindran Thayran , Institute ... , , , , , ... RT-PCR by using Eppendorf's Mastercycler gradient , , ... often carried out at the Institute of Health and Community Medicine, Universiti , ...
Cached Biology Technology:The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 2The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 3The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 4The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 5Amplification of Epstein-Barr Virus Exon C with Difficult Primers , Using Eppendorf Mastercycler gradient 2Amplification of Epstein-Barr Virus Exon C with Difficult Primers , Using Eppendorf Mastercycler gradient 3Amplification of Epstein-Barr Virus Exon C with Difficult Primers , Using Eppendorf Mastercycler gradient 4Amplification of Epstein-Barr Virus Exon C with Difficult Primers , Using Eppendorf Mastercycler gradient 5Optimized Dengue RT-PCR 2Optimized Dengue RT-PCR 3
Maxi 14 Hybridization Oven. 14 bottle (35 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 medium bottles, pack of mesh, bottle gripper and d...
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
... The Neural Stem Cell Expansion Kit - ... in vitro NSC expansion as a monolayer ... specially formulated N-2 Plus Media Supplement, which has ... K.K. et al . (1996) Genes & ...
... is a preparation of deoxyribonuclease I ... to produce 3-hydroxyl oligonucleotides. This preparation ... where maintaining the integrity of RNA ... for use with the Core Footprinting ...
Biology Products: