Navigation Links
Boston Univ., Veterans Affairs find sports brain trauma may cause disease mimicking ALS
Date:8/17/2010

n multiple genetic and environmental risk factors.

In this study, funded in part by an unrestricted gift from the National Football League (NFL) to the CSTE, McKee found that when they died, all 12 athletes showed neuropathological evidence of chronic traumatic encephalopathy (CTE), a progressive degenerative brain disease characterized by deposits of an abnormal form of tau protein and believed to be caused by repetitive head trauma. In the three athletes with motor neuron disease, abnormal tau protein deposits were not only found throughout the brain, but also in the spinal cord.

CSTE researchers also discovered that 10 of 12 CTE victims had a second abnormal protein, TDP-43, in their brains. Of those 10, only three had TDP-43 in the brain and the spinal cord, and those were the three athletes diagnosed with motor neuron disease. TDP-43 is also found in individuals with sporadic ALS although in the athletes with repetitive brain trauma, the TDP-43 pathology was more severe than found in sporadic ALS and was accompanied by extensive tau pathology. The brains and spinal cords of normal individuals show no TDP-43 or tau deposition.

These new findings suggest that the motor neuron disease that affected the three athletes is similar to, but distinct from sporadic ALS and represents a disease never described previously in the medical literature. This new disease, referred to as chronic traumatic encephalomyopathy (CTEM) by McKee and colleagues is likely caused by the repetitive head trauma experienced by athletes in contact sports.

The association between head trauma and ALS is supported by the medical literature, in which the risk of ALS has been reported to be higher among contact sport athletes and veterans. A study of professional soccer players in Italy found that the incidence rate of ALS was 6.5 times higher than in the general population. An increased incidence of ALS has also been reported in American football players, in
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Worlds largest meeting of ear, nose and throat doctors to convene in Boston Sept. 26-29, 2010
2. Boston University School of Medicine researcher awarded the 2010 Avanti Award in Lipids
3. Boston University reseachers develop faster, cheaper DNA sequencing method
4. Grant brings real-world science to Boston classrooms
5. Boston University scientists first to see RNA network in live bacterial cells
6. Boston University engineer to use $2.5 million NIH grant to cells reaction to physical force
7. Boston University biomedical engineers teach bacteria to count
8. Boston College chemistry professor Udayan Mohanty receives a 2009 Guggenheim Fellowship
9. Agent Orange exposure increases veterans risk of aggressive recurrence of prostate cancer
10. 2008 Ullyot Public Affairs Lecture
11. Sports rehabilitation and injury prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... 07, 2015 Research ... of the "Biometrics for Banking; Market & ... report to their offering. The adoption ... this growth and the forecast is that by ... for companies involved in delivering biometric systems to ...
(Date:7/8/2015)... YORK , July 8, 2015  BD (Becton, ... BD & Guidepoint Mentor, a new program ... Guidepoint,s expert network services. BD is ... to improve healthcare delivery and outcomes and, with the ... entrepreneur will be able to directly engage with industry ...
(Date:7/7/2015)... 7, 2015  Based on its recent analysis ... recognizes Credence ID, LLC with the 2015 Asia-Pacific ... the Year Award. Credence ID has developed a ... mission of offering enrollment and identification solutions to ... ID was formed by experts from the mobile ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5
... Boyce Thompson Institute Associate Scientist Thomas Brutnell is ... researchers who are attempting to solve one of the ... to predict how plants will grow and develop based ... where they are found or planted. Solving this problem ...
... BLOOMINGTON, Ind. -- Two recently diverged populations of a ... contribute to the reproductive isolation that accompanies the origin ... of organic compounds present in the preen oils of ... Ecology . "There,s so much we don,t know ...
... play a major role in how people respond to stress, ... journal Psychophysiology , the investigation was led by scientists ... in collaboration with colleagues from the Universit du Qubec ... who are more defensive are at increased cardiovascular risk, whereas ...
Cached Biology News:BTI's Brutnell leads part of NSF Computational Plant Biology Research System 2BTI's Brutnell leads part of NSF Computational Plant Biology Research System 3Could smell play a role in the origin of new bird species? 2Could smell play a role in the origin of new bird species? 3Men and women respond differently to stress 2
(Date:7/24/2015)... BEIJING , July 24, 2015 Origin Agritech ... supplier of crop seeds in China , ... third quarter fiscal year 2015 ended June 30, 2015, before ... The Company will host a teleconference on August 5th, 2015, ... time to discuss the results. To participate in ...
(Date:7/24/2015)... 2015 , Adds integrated small ... product offering for chronic kidney disease and oncology patients ... complications and dermatology , Increases group revenue and ... ,the Company"), a leading China -based ... biopharmaceutical products, today announced that it has acquired the ...
(Date:7/23/2015)... LOS ANGELES , July 23, 2015 ImmunoCellular ... plans to report financial results for the second quarter 2015 ... hold a conference call and webcast on that day at ... results and provide a business update. The call will be ...   , , , LIVE CALL: ...
(Date:7/23/2015)... , ... July 23, 2015 , ... Science and technology ... to new drug therapies and devices – according to Susan Chang, MD, director of ... session on how science and new technology are impacting the development of new treatments ...
Breaking Biology Technology:Origin Agritech Limited to Announce Third Quarter Fiscal 2015 Unaudited Financial Results on August 5th, 2015 2Origin Agritech Limited to Announce Third Quarter Fiscal 2015 Unaudited Financial Results on August 5th, 2015 33SBio Acquires Zhejiang Wansheng Pharmaceutical 23SBio Acquires Zhejiang Wansheng Pharmaceutical 33SBio Acquires Zhejiang Wansheng Pharmaceutical 4ImmunoCellular Therapeutics to Report Second Quarter 2015 Financial Results on August 6, 2015 2Experts Present How Science and New Technology are Driving New Brain Tumor Treatments and Improving Quality of Life 2Experts Present How Science and New Technology are Driving New Brain Tumor Treatments and Improving Quality of Life 3
... Milwaukee TeraMedica has developed a ... at the Mayo Clinic and UW-Madison, is designed to ... than individual departments. , ,Paul Markham, vice president of ... software when he saw that medical firms were designing ...
... a bill that allows researchers to work together without ... in a patent dispute. After a 1997 court decision, ... art, said Andy Cohn, spokesperson for the Wisconsin ... patent claim though it has caused little trouble ...
... After two days of demostrating Wisconsin's breakthroughs in biotechnology, ... last Wednesday with a discussion of what the state must ... praised the strides Wisconsin has made in research, but explained ... , ,Tom Still, moderator of the panel and president of ...
Cached Biology Technology:TeraMedica offers system integration tool for hospitals 2Out-of-state VCs offer advice on biotech investments 2Out-of-state VCs offer advice on biotech investments 3
... Versatile state of the Art GLP ... to dual 38,000 L fermentation. ... to production. Aseptic operation capable ... Fed-Batch, and Continuous Modes. Hosts ...
ExonBio Service provides one-stop recobinant protein shopping from cloning, expression and purification. Price including gene cloning....
TRBP1 Antibody...
Request Info...
Biology Products: