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Boston College profs study oxidative stress subcellular to discover its role in diseases
Date:9/14/2007

rk together," said Boston College Professor of Biology Thomas Chiles, a study co-author whose lab was involved in the research.

Chiles says the collaboration began a few years ago when he and Professor Shana Kelley then a faculty member in the Boston College Chemistry Department now at the University of Toronto were serving on a committee together. She described her research to Chiles, and the two scientists began exchanging ideas and sharing lab resources and staff to work on the project.

Kelley had designed highly innovative chemical probes to target specific locations within the cell, Chiles explains. "Once inside, she knew the compounds were killing the cell, but she needed another perspective, because she was dealing with questions of a biological nature. How were these compounds killing the cell" How does a cell survive oxidative stress"

"Past research on oxidative stress focused on the cell as a whole, so it was difficult to ascertain exactly what was happening at the molecular level. But with these compounds developed through Shana's lab, we can begin to understand the specifics of the cell's response to oxidative stress.

"The next step is to look at whether the changes occurring within the cell are its response to the oxidative stress caused by the compounds, or if the compounds themselves are triggering the changes."


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Contact: Kathleen Sullivan
kathleen.sullivan.1@bc.edu
617-552-8644
Boston College
Source:Eurekalert

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