Navigation Links
Boosting supply of key brain chemical reduces fatigue in mice
Date:12/20/2010

Researchers at Vanderbilt University have "engineered" a mouse that can run on a treadmill twice as long as a normal mouse by increasing its supply of acetylcholine, the neurotransmitter essential for muscle contraction.

The finding, reported this month in the journal Neuroscience, could lead to new treatments for neuromuscular disorders such as myasthenia gravis, which occurs when cholinergic nerve signals fail to reach the muscles, said Randy Blakely, Ph.D., director of the Vanderbilt Center for Molecular Neuroscience.

Blakely and his colleagues inserted a gene into mice that increased the production of a protein called the choline transporter at the neuromuscular junction.

The choline transporter is vital to the capacity for muscle contraction including the ability to breathe because it regulates the supply of choline, the precursor to acetylcholine. "We reasoned that giving more of this protein might enhance muscle function and reduce nerve-dependent fatigue," Blakely said.

Other researchers have manipulated the gene for the muscle tissue growth factor myostatin to produce animals with greater strength and endurance, but Blakely said this may be the first time "neural endurance" was enhanced by manipulating the nerves that innervate muscle.

Drugs that increase choline transporter activity "could represent a novel therapeutic strategy" for myasthenia gravis and a wide range of other disorders that involve cholinergic signaling deficits, Blakely said.

These disorders include muscular dystrophy, congestive heart failure, depression, schizophrenia, Alzheimer's disease and attention-deficit hyperactivity disorder (ADHD). "The brain uses acetylcholine for a wide variety of functions, including the ability to sustain attention," Blakely noted.

Last year, Blakely and his colleagues reported that a variation in the choline transporter gene is associated with the "combined" type of ADHD, which is characterized by both inattention and hy
'/>"/>

Contact: Bill Snyder
bill.snyder@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. U of M plant scientist uncovers clues to yield-boosting quirks of corn genome
2. New study calls for greater awareness of food supply for children with diabetes
3. Shaping the future of the High Plains water supply
4. Chip Supply Hosts Visit by U.S. Senator George LeMieux
5. Eurofins MWG Operon signs contract to supply oligonucleotides to Research Councils
6. Supply and demand
7. Some trees farm bacteria to help supply nutrients
8. Does the existing standard of care supply energy sources to brain tumor cells?
9. Chip Supply Welcomes Lupton Associates to Sales Team
10. Multicard to Supply Secure IT Kits Under German Federal Governments Electronic ID Program
11. SCM Microsystems to Supply Readers for German Electronic ID Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... of Entiat on Tuesday, July 8, 2014. Despite the ... over 1,000 acres by evening. Three outbuildings were damaged. ... the Washington Department of Natural Resources. The fire ... fire control strategies and tactics. Other cooperators include the ... Resources, (WA DNR), Bureau of Land Management, Chelan County ...
(Date:7/11/2014)... in German . ... uses the refraction of X-rays through a specimen instead ... this method are often of much higher quality than ... of Prof. Franz Pfeiffer are particularly interested in developing ... including X-ray phase-contrast imaging. One main goal is to ...
(Date:7/11/2014)... July 10, 2014---A team of researchers from The Chinese ... identified a gene of wild soybean linked to salt ... grow in saline soil. This study published online in ... unveil novel genomic information for crop improvement. , Soybean ... domestication and human selection, cultivated soybeans have less genetic ...
Breaking Biology News(10 mins):New simple setup for X-ray phase contrast 2BGI reports a novel gene for salt tolerance found in wild soybean 2
... COLD SPRING HARBOR, N.Y. (Thurs., Oct. 1, 2009) ... choice for understanding where and when genes are expressed in ... physiological or environmental conditions. Recent discoveries have revolutionized our ... active in a much wider set of biological processes than ...
... Spatial Integrated Systems, Inc. ("SIS"), a leader in ... digital 3D data capture and processing technologies, announced ... been published for "system and method for generating ... No. US2009/0169095A1. , "We are pleased that our ...
... BATON ROUGE For Sophie Warny, LSU assistant professor of ... Natural Science, years of patience in analyzing Antarctic samples with ... and colleagues from around the world now have proof of ... 15.7 million years ago and lasted for a few thousand ...
Cached Biology News:Cold Spring Harbor Protocols features RNA analysis methods 2Spatial Integrated Systems, Inc. Files Patent Application 2Algae and pollen grains provide evidence of remarkably warm period in Antarctica's history 2Algae and pollen grains provide evidence of remarkably warm period in Antarctica's history 3Algae and pollen grains provide evidence of remarkably warm period in Antarctica's history 4
(Date:7/10/2014)... Capital, a firm specializing in acquiring and managing food ... the Slim-Fast brand from Unilever. Unilever will retain a ... were not disclosed. Slim-Fast is a branded ... shakes, powders, bars and snacks to retail customers throughout ... United Kingdom and Ireland.  The ...
(Date:7/10/2014)... 15, 2014 -- According to the International Atomic ... security comes from terrorists acquiring sufficient quantities of ... a crude nuclear explosive device. The IAEA also ... have involved gram-level quantities, which can be challenging ... to a new study appearing this week in ...
(Date:7/10/2014)... Understanding the basis of psychiatric disorders has been extremely ... increase risk but are insufficient to cause disease. Now ... Cell Press journal Cell Stem Cell describe ... genetic risks interact with other risk factors or environmental ... Their research pinpoints a genetic variant that may predispose ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
Breaking Biology Technology:Kainos Capital Acquires Slim-Fast From Unilever 2Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... Neurognostics, Inc ., a Wisconsin company specializing in functional ... that the Food and Drug Administration (FDA) issued a ... MindState fDAD. MindState fDAD had previously received clearance ... The Special 510(k) allows Neurognostics to enhance fDAD by ...
... eMed , a Merge Healthcare company and a ... the release of Cedara I-ReadMammo digital mammography workstation ... product is designed to help organizations streamline breast ... mammography. , ,I-ReadMammo was designed to help ...
... a country that invented take out food, that is in love ... in motion, it was inevitable that work and indeed the workplace ... the place where knowledge work happens has shifted from primarily office ... a subway car, walking down the street or of course, hanging ...
Cached Biology Technology:Who moved the workplace? 2Who moved the workplace? 3Who moved the workplace? 4
... G bind specifically to Fc regions of ... G conjugates are commonly used as affinity ... subtypes from serum, hybridoma ascites fluids, tissue ... reagents are also commonly used to capture ...
... Dermal Fibroblasts (Mouse/BalbC) and media. This cell ... and is guaranteed to provide an additional ... date supplied, when used with the recommended ... 18.5 ,Applications: ,Cultivation: Plate at ...
... A and Protein G bind specifically to ... A and Protein G conjugates are commonly ... (antibodies) and immunoglobulin subtypes from serum, hybridoma ... biological fluids. These reagents are also commonly ...
... statistical software package for scientists and engineers ... without being a statistical expert.Just answer a ... and SigmaStat suggests the appropriate test. It ... assumptions and suggests another test if your ...
Biology Products: