Navigation Links
Boosting blood system protein complex protects against radiation toxicity
Date:6/24/2012

CINCINNATI - New research in Nature Medicine shows that boosting a protein pathway in the body's blood making system protects mice from otherwise fatal radiation poisoning.

Scientists in the multi-institutional study posted online by the journal on June 24 say their findings open the potential for new treatments against radiation toxicity during cancer treatment or environmental exposures such as in a nuclear explosion or accident.

By identifying a target-specific intervention to protect the hematopoietic system against radiation toxicity, the study addresses a largely unmet challenge, according to the researchers.

"These findings suggest that pharmacologic augmentation of the activity of the Thbd-aPC pathway by recombinant Thbd (thrombomodulin) or aPC (activated protein C) might offer a rational approach to the mitigation of tissue injury and lethality caused by ionizing radiation," the scientists write in their manuscript. "Recombinant human aPC has undergone extensive clinical testing in patients, and recombinant soluble human Thbd is currently being investigated for efficacy in antithrombotic therapy in humans. Our data encourage the further evaluation of these proteins for their radio-mitigating activities."

The study reveals a previously unknown function of the Thbd-aPC pathway in radiation mitigation. The pathway is normally known for its ability to prevent the formation of blood clots and help the body fight infections. The researchers found the pathway helps blood cells in the bone marrow recover from injury caused by radiation exposure. They demonstrated that pharmacologic boosting of this pathway with two drugs tested for the treatment of thrombosis or infection (recombinant Thbd and aPC respectively) can be used in mice to prevent death caused by exposure to lethal doses of radiation.

In all instances of treatment with recombinant soluble Thbd or aPC, the result was accelerated recovery of hema
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Scientists produce eye structures from human blood-derived stem cells
3. Blood on the menu
4. Glycemic index foods at breakfast can control blood sugar throughout the day
5. Detecting breast cancers fingerprint in a droplet of blood
6. Second-generation drug used for hypertension aids heart function independent of blood pressure
7. Changes in brains blood flow could cause brain freeze
8. Leeches are DNA bloodhounds in the jungle
9. VolitionRX Raises Over $1 Million To Begin Clinical Trials of Blood Based Diagnostic Tests
10. New microscope uses rainbow of light to image the flow of individual blood cells
11. John Theurer Cancer Center presents significant blood cancer research at 2012 ASCO Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... launch in December 2014, the 1U™ app has ... to remember their usernames and passwords through replacing the antiquated ... assist people who have struggled to remember usernames and passwords, ... focuses on redefining identity, announced today that it is offering ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM announced today ... to confirm its adherence to current U.S. Food and ... conduct regulated smart device and smart phone application trials ... quality. "HITLAB is determined to improve global ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... this week,s issue of "New Scientist" magazine, research by Rice ... is on one,s mind about politics may be influenced by ... this topic for a number of years, and his team ... in the United States and supplemented it with findings from ...
... Quest Product Development, teaming with,Ball Aerospace & ... successfully demonstrated a new thermal insulation. NASA has ... II grant to develop and,commercialize this advanced thermal ... NASA,s new,spacecraft and exploration missions would preserve rocket ...
... Rochet, a research scientist at IFREMER (The French Research ... the prestigious Pew Fellowship in Marine Conservation to determine ... to the delicately balanced marine ecosystem. She will use ... use of that technique, and to further improve its ...
Cached Biology News:Colorado Engineering Firms Win NASA Grant to Develop Innovative Insulation for Next Generation Spacecraft - Super-Insulation May Allow Future Energy Efficient Appliances 22008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 22008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 32008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 4
(Date:1/22/2015)... GEA Niro Soavi the leader in high ... PandaPLUS 2000, which is ideal for new applications for ... disruption . This compact laboratory homogenizer is the perfect ... food additives and ingredients as well as for the ...
(Date:1/22/2015)... CAMBRIDGE, Mass (PRWEB) January 21, 2015 Cambridge ... Semantic Web technology, today announced that 2014 was a record-breaking ... expanding the capabilities of the Anzo Smart Data Platform and ... discover and utilize insights from diverse data which led to ...
(Date:1/22/2015)... 22, 2015 Protocol Networks brings independent ... team of brand-neutral, independent consultants, Protocol Networks has recently ... that over the years, his company has attracted several ... of Plainfield, as well as others. With the success ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Pipette.com ... Offer to their comprehensive portfolio of Eppendorf products. ... customers to purchase a Centrifuge 5424/5424 R and receive ... of either Eppendorf Research plus or Eppendorf Reference 2 ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... , Revamilast is a PDE4 inhibitor, under ... The molecule successfully completed pre-clinical trials and Phase I studies ... in the UK , , Glenmark has initiated global ... Huge unmet medical need as globally they are over 300 ...
... 9, 2011 Accuray Incorporated (Nasdaq: ARAY ), ... is scheduled to present at the Wedbush Life Sciences: Management ... at 9:10 a.m. ET/6:10 a.m. PT. A live ... investor relations page of the Company,s Web site at ...
... 2011 Reportlinker.com announces that a new ... catalogue: Biochips: Genosensors, Microarrays, ... http://www.reportlinker.com/p0591346/ Biochips-Genosensors-Microarrays-Labs-On-The-Chip .html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... Microarrays and Labs-on-the-Chip are extensions of biosensor ...
Cached Biology Technology:Glenmark Initiates Phase IIb Human Trials Globally for its Novel Molecule 'Revamilast' 2Glenmark Initiates Phase IIb Human Trials Globally for its Novel Molecule 'Revamilast' 3Glenmark Initiates Phase IIb Human Trials Globally for its Novel Molecule 'Revamilast' 4Biochips: Genosensors, Microarrays, Labs-On-The-Chip 2
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
... 100-240 V, uses multiplex suspension array technology ... up to 100 proteins and peptides in ... is composed of up to 100 color-coded ... conjugated with a unique reactant specific to ...
... (HTF) system, 100-240 V, is an optional ... that automates delivery of up to 20 ... array reader. The HTF system automatically draws ... container to constantly maintain a reservoir of ...
Cell Culture Flask, 75 cm, nontreated polystyrene...
Biology Products: