Navigation Links
Bone marrow transplant arrests symptoms in model of Rett syndrome
Date:3/18/2012

d complex functions that include sustaining a healthy environment for neuronal growth and maintenance. Microglia are small glial cells that participate in the brain's immune response. One of their roles is to clean up normal cellular debris in the brain through the process of phagocytosis. Kipnis and his team discovered that when microglia lack properly functioning Mecp2, they are unable to perform this crucial duty efficiently. Because microglia are derived from immune progenitor cells, it is possible to replace them via a bone marrow transplant.

First author Nol Derecki and his colleagues began their work with male Rett mouse models, which lack any Mecp2. These Mecp2-null mice mimic the human disorder, with neurological symptoms beginning to appear at about 4 weeks of age and an approximate life expectancy of only 8 weeks. Radiation treatment was administered at 4 weeks, followed by a bone marrow transplant from normal (wild-type) mice. As engraftment - the migration and repopulation of new microglia - took place, the Rett mice began to grow instead of fail. Body and brain sizes approached those of wild-type mice, gait improved and mobility increased significantly. There were no signs of the severe tremors seen in untreated mice. Apneas and other breathing irregularities were markedly diminished. The oldest of these mice is now almost a year. Work with female Rett mouse models at more advanced stages of disease is currently underway.

Gail Mandel, Ph.D., whose Rett research focuses on astrocytes, another type of glial cell impaired by mutations in MECP2, comments, "A fascinating aspect of these findings is the data suggesting that deficits in the engulfing properties of microglia are a crucial aspect of Rett neuropathology. It will now be necessary to develop cellular assays to determine all the ways these immune cells are bolstering neuronal functions and whether they can be therapeutically harnessed." Dr. Mandel is a Senior Scientist at the V
'/>"/>

Contact: Monica Coenraads
monica@rsrt.org
203-445-0041
Rett Syndrome Research Trust
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Bone marrow-derived cells differentiate in the brain through mechanisms of plasticity
2. Phase I trial begins using gene therapy and bone marrow stem cells in the treatment of brain cancer
3. 3-D long-term bone marrow culture to analyze stromal cell biological function
4. Using bone marrow to protect the brain
5. Inhibiting cell signaling pathway may improve bone marrow transplant success rate
6. First US trial of bone-marrow stem cells for heart attack patients proves safe
7. Researchers identify how bone-marrow stem cells hold their breath in low-oxygen environments
8. Researchers find that one type of stem cell creates a niche for another type in bone marrow
9. Using bone marrow stem cells to treat critically ill patients on verge of respiratory failure
10. High cholesterol levels affect mobilization of cells from the bone marrow
11. Bone marrow cell transplants to benefit those with heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bone marrow transplant arrests symptoms in model of Rett syndrome
(Date:12/19/2014)... VIEW, Calif. , Dec. 18, 2014  23andMe, ... publication of a study that pinpoints fine-scale differences in ... United States . Since immigrants first ... the United States has served as a ... illuminates how American history and the ongoing mixing of ...
(Date:12/17/2014)... Dec. 15, 2014 The Defense Logistics ... easier to detect and prevent counterfeit microcircuits from ... the agency started performing an in-house microcircuit anti-counterfeit ... the authenticity of purchased microcircuits while increasing their ... control measures will be conducted at DLA,s Electronics ...
(Date:12/17/2014)... DUBLIN , Dec. 16, 2014 Research ... announced the addition of the "Global Chemical ... http://photos.prnewswire.com/prnh/20130307/600769 ... is the increasing demand for medical sensors in ... patient data for quick and correct diagnosis during ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... a century-old observational technique have determined the precise configuration ... its distinctive flavor. That might not sound like ... findings overturn results reported in scientific literature in the ... to treat diabetes, some types of cancer and other ...
... A federal agency has turned to Clemson University,s South ... data that will help it assess the environmental impact ... and coastal environments of the northern Gulf of Mexico,s ... and Wildlife Research Unit will fill data holes on ...
... impossible, according to scientists writing in Trends in Ecology ... of the University of Southampton. The term "sexual selection" ... ability to repel rivals, meet mates and pass on genes. ... how do palaeontologists know that sexual selection operated in fossil ...
Cached Biology News:Beer's bitter compounds could help brew new medicines 2Clemson University researchers to study oil and gas operations' impact on Gulf Coast pelicans 2Survival of the prettiest: Sexual selection can be inferred from the fossil record 2
(Date:12/24/2014)... 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues  ("BioLife" ... its 2015 Annual Meeting of Stockholders on May 4, ... date for the Annual Meeting represents a change of ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 GMO corn ... biotechnology company, Syngenta, are in the process of being ... The consolidated case is In Re: Syngenta AG MIR ... District Court for the District of Kansas. , Management ... been handed over to U.S. District Judge John W. ...
(Date:12/24/2014)... SoundConnect’s 2015 ... introduce cutting edge communication technology, provide continued ... platform upgrades. This webinar series demonstrates online ... their quest to leverage web conferencing’s most ... SoundConnect’s Marketing Manager, Seanna Baumgartner, “Our webinars ...
(Date:12/24/2014)... Long Island, New York (PRWEB) December 23, 2014 ... , and the Long Island Affiliate of ITRA Global, the ... economy’s slow but steady recovery. This is evidenced by ... and the strong stock market. Low energy costs have ... low. The only negative is the housing market remaining ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
... Tanya Townsend didn't have much time to pass the all-digital ... other information technology directors have an opportunity to start fresh ... new processes? , ,Not many, and when the still-to-be ... for a chief technology executive in 2004, Townsend beat out ...
... sky. It's a bird. It's a plane. It's super hype - ... single bound. Indeed, lately the media has been saturated with stories ... the mass exodus of Baby Boomers from the workforce. , ,Many ... trend and its impacts on businesses are black and white. But ...
... When it comes to real estate acquisitions, many smart investors ... and have invested it into REITs (Real Estate Investment Trusts). ... returns to their investors. These are great returns on investment, ... marble facades and talking elevators? , ,What many of these ...
Cached Biology Technology:CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 2CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 3CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 4CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 5Shades of gray: Business impacts of an aging workforce 2Shades of gray: Business impacts of an aging workforce 3Shades of gray: Business impacts of an aging workforce 4Shades of gray: Business impacts of an aging workforce 5Shades of gray: Business impacts of an aging workforce 6Lack of connectivity is real estate's hidden time bomb 2Lack of connectivity is real estate's hidden time bomb 3Lack of connectivity is real estate's hidden time bomb 4Lack of connectivity is real estate's hidden time bomb 5
Anti-rat Dipeptidyl Peptidase IV (DPP IV), CD26, Clone 5E8, Monoclonal Antibody...
JAB1 Immunogen: Synthetic peptide, conjugated to KLH, corresponding to residues S(201) E Y Q T I P L N K I E D F G V(216) of human JAB1. The sequence is identical in mouse and rat. Storage: -...
... The FastPlax Antibody is used to ... on the surface of infected cells as ... the basis of the FastPlax Titer Kit, ... just 25-48 hours. The FastPlax ...
synaptotagmin XIV-like [Source:RefSeq_peptide;Acc:NP_114120] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: