Navigation Links
Bone marrow cell transplants to benefit those with heart disease
Date:2/24/2010

to Prof. Enio Buffolo, co-author from the same institution, up to 15 percent of patients with coronary artery disease present severe, disabling angina pectoris that cannot be controlled by combinations of current therapies, including drug therapy, coronary angioplasty, or coronary by-pass surgery.

"This results in a substantial decrease in the quality of life for the refractory angina patient," added Prof. Enio Buffolo.

Bone marrow is a natural source of a broad spectrum of cytokines involved in controlling angiogenic and inflammatory processes. Bone marrow white blood cells therefore play an important role in the angiogenic mechanism, contributing to the revascularization of the heart.

The researchers selected the intramyocardial route for injection based on prior experimental data showing higher myocardial stem cell uptake. Endpoints for patient improvement were based on the Canadian Cardiovascular Society Angina Classification (CCSAC) system. According to Dr. Hossne, the ReACT formulation, designed in compliance with Good Manufacturing Practices (GMP) standards criteria, was found to be safe and effective, supporting further study with a larger number of patients.

"Patient improvement by the subjective CCSAC measures was followed by a correlated reduction in the myocardium ischemic area," concluded Dr. Hossne. "This strongly suggests neoangiogenesis as the main mechanism of action for these cells."

Contact: Dr. Nelson Americo Hossne, Jr., Cardiovascular Surgery Division, Surgery Department, Paulista School of Medicine, Federal University of Sao Paulo, Botucato St.
740 Sao Paulo, Brazil ZIP 04023-900.
Tel: +55-11-8166-5050; fax: +55-11-5052-0386,
Email: nelson.hossne@gmail.com


Apelin helps heart function after bone marrow transplant

Apelin, a newly described inotropic peptide (related to the force of heart muscle contracti
'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Anorexics found to have excess fat-- in their bone marrow
2. MSU researcher links diabetic complication, nerve damage in bone marrow
3. Gene mismatch influences success of bone marrow transplants
4. Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue
5. Multiple route bone marrow stem cell injections show promise to treat spinal cord injury
6. Biomedical researchers create artificial human bone marrow in a test tube
7. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
8. NC State first university in nation to offer canine bone marrow transplants
9. Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
10. Researchers engineer pancreatic cell transplants to evade immune response
11. High blood sugars impact on immune system holds clues to improving islet cell transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2015)... 25, 2015  Australia,s market for wearable technologies is ... saw the advent of several trials and prototypes. The ... is expected to ignite interest in wearables as well ... Australia . This in turn will spur greater ... new partnerships amongst vendors and distributors. ...
(Date:5/21/2015)... 2015 According to a ... (Hardware, Software, Services), by Applications (Surveillance (Airborne, Maritime, ... End-Users (Military & Defense & Commercial) - Global ... Market is expected to grow from $7252.0 Million ... a Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/20/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... owned subsidiary, 3D-ID LLC, a company engaged in biometric ... the biometrics technology portion of the recently awarded TIES ... Department of the Army. 3D-ID LLC has ... government, law enforcement and security agencies. ...
Breaking Biology News(10 mins):Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 2Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 3Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 4Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3
... in German . , EUMINAfab offers ... nanotechnologies for users from science and industry. Today, this ... Ten leading institutions from research and industry in eight ... high-tech installations along with the corresponding scientific and technological ...
... about how fat causes hypertension have been identified by researchers ... obese people and maybe some thin ones too ... best for them. Medical College of Georgia researchers ... mice at risk for hypertension by interfering with an endogenous ...
... of the world,s top cancer specialists will be in ... International Cancer Symposium organised by Queen,s University. The ... and Cancer Research (CCRCB) on Wednesday and Thursday, will ... and Europe, including those from Harvard Medical School in ...
Cached Biology News:Scientific pathways into the nanoworld 2Scientific pathways into the nanoworld 3New information about how fat increases blood pressure could help identify those at risk 2New information about how fat increases blood pressure could help identify those at risk 3International event brings world's top cancer doctors to Queen's 2International event brings world's top cancer doctors to Queen's 3
(Date:5/26/2015)... , May 26, 2015 Pharmaco-Kinesis Corporation ... (NOCAB) recently convened at Shutters on the Beach in ... the development status of the Company,s innovative Metronomic Biofeedback ... to locally deliver chemotherapy over time to a target ... delivery capacity and biofeedback system in real-time.  ...
(Date:5/26/2015)... , 26. mája 2015 Kevin ... svojej rodiny prezidentom Barackovi Obamovi a Billovi Clintonovi ... so stratou Dr. Rongxiang Xu , otca ... Dr. Xu bol pionier, inovátor, ... jeho odhodlanie v oblasti vedy a príkladné vedenie ...
(Date:5/26/2015)... MENLO PARK, Calif. , May 26, 2015 /PRNewswire/ ... focused on the emerging field of regenerative medicine, today ... issued in June 2014 were exercised prior to their ... to the Company of $11.7 million. "We ... Pedro Lichtinger , President and CEO of Asterias. "This ...
(Date:5/26/2015)... , May 26, 2015 /PRNewswire/ - Fluorinov Pharma ... of Luke M. Beshar to its Board ... financial and pharmaceutical industry expertise as Fluorinov accelerates its ... the Fluorinov team, it is a pleasure to welcome ... a significant impact on the strategy, financial strength and ...
Breaking Biology Technology:Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 2Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 3Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 4Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 5Dr. Rongxiang Xu, O legende 2Asterias Biotherapeutics Receives $11.7 Million in Proceeds from Exercise of Warrants 2Asterias Biotherapeutics Receives $11.7 Million in Proceeds from Exercise of Warrants 3Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 2Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 3
... University today announced the public launch of the Tufts ...   The Institute is a university-wide, global ... diverse portfolio of drug discovery and development partnerships. ... by Tufts University School of Medicine and Tufts University,s ...
... Calif., Feb. 11, 2011 Abaxis, Inc. (Nasdaq: ... blood analysis instruments for the medical, research and veterinary ... Scandinavian Micro Biodevices APS, ("SMB"), a privately-held developer and ... SMB, based in Copenhagen, Denmark, has been ...
... 11, 2011 ImmunGene, Inc., a privately held drug ... that a profile of the company and its interferon ... in the February 7 issue of BioCentury , ... pharma and biotech industries. ( www.biocentury.com ) ...
Cached Biology Technology:Tufts Launches Institute for Biopharmaceutical Partnerships 2Tufts Launches Institute for Biopharmaceutical Partnerships 3Tufts Launches Institute for Biopharmaceutical Partnerships 4Abaxis Makes $2.8 Million Equity Investment in Scandinavian Micro Biodevices APS 2Abaxis Makes $2.8 Million Equity Investment in Scandinavian Micro Biodevices APS 3Abaxis Makes $2.8 Million Equity Investment in Scandinavian Micro Biodevices APS 4ImmunGene's Interferon Payload Technology Platform Featured in BioCentury Magazine 2
... of several isoprostanes produced from arachidonic acid during ... in the rat. 8-iso PGE2 inhibits U-46619 or ... and 5 µM, respectively. When infused into the ... of 4 mg/kg/min, 8-iso PGE2 decreases the GFR ...
DNA Polymerase I Large (Klenow) Fragment is a DNA polymerase that lacks the 5'Cut Site3' exodeoxyribonuclease activity of intact DNA Polymerase I but it contains the 3'Cut Site5' exodeoxyribonuclease...
... Centra-CL5R multi-purpose centrifuge offers both high-speed ... assortment of rotor options, making it ... applications., Maximum Versatility , High-speed ... angle rotors or high-volume (4 x 250mL) ...
Guanylate Kinase Purified Anti-Mouse, Anti-Rat clone 28, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Biology Products: