Navigation Links
Bone marrow cell transplants to benefit those with heart disease
Date:2/24/2010

Tampa, Fla. (February 24, 2010) Two studies published in the latest issue of Cell Transplantation (18:12) may lead to new treatments for the treatment of heart diseases. The first study, carried out by a team of Brazilian researchers, found that cell transplantation of bone marrow mononuclear cells (BMMCs) directly into the heart benefited patients suffering from refractory angina. A separate study carried out by researchers in the Peoples' Republic of China found that apelin, a newly described inotropic peptide, improves heart function following transplantation of BMMCs.

The results of these studies and others are available on-line free of charge at http://www.ingentaconnect.com/content/cog/ct/ .

ReACT bone marrow cell transplants help refractory angina

A team of Brazilian researchers has evaluated the safety and efficacy of a surgical procedure involving multiple injections into the heart (intramyocardial) of a bone marrow mononuclear cells (BMMCs) formulation derived from the patient (autologous) called "Refractory Angina Cell Therapy (ReACT)". The researchers found that the procedure benefitted all eight of the refractory angina patients in the study, all of whom had previously received surgical revascularization.

"The large fraction of monocytes in the ReACT formula appears to be related to the new blood vessel growth, or angiogenesis, that restores perfusion on the myocardial ischemic areas after the cell transplantation," said corresponding author Dr. Nelson Americo Hossne, Jr. of the Paulista School of Medicine, Federal University of Sao Paulo. "For our patients, angina symptom relief began as early as three months post-procedure with continuing improvement through the twelfth month and sustained improvement past 18 months. Symptom relief improved in all patients, suggesting that the effect is sustained, not transitory."

According to Prof. Enio Buffolo, co-author from the same institution, up to 15 percent of patients with coronary artery disease present severe, disabling angina pectoris that cannot be controlled by combinations of current therapies, including drug therapy, coronary angioplasty, or coronary by-pass surgery.

"This results in a substantial decrease in the quality of life for the refractory angina patient," added Prof. Enio Buffolo.

Bone marrow is a natural source of a broad spectrum of cytokines involved in controlling angiogenic and inflammatory processes. Bone marrow white blood cells therefore play an important role in the angiogenic mechanism, contributing to the revascularization of the heart.

The researchers selected the intramyocardial route for injection based on prior experimental data showing higher myocardial stem cell uptake. Endpoints for patient improvement were based on the Canadian Cardiovascular Society Angina Classification (CCSAC) system. According to Dr. Hossne, the ReACT formulation, designed in compliance with Good Manufacturing Practices (GMP) standards criteria, was found to be safe and effective, supporting further study with a larger number of patients.

"Patient improvement by the subjective CCSAC measures was followed by a correlated reduction in the myocardium ischemic area," concluded Dr. Hossne. "This strongly suggests neoangiogenesis as the main mechanism of action for these cells."

Contact: Dr. Nelson Americo Hossne, Jr., Cardiovascular Surgery Division, Surgery Department, Paulista School of Medicine, Federal University of Sao Paulo, Botucato St.
740 Sao Paulo, Brazil ZIP 04023-900.
Tel: +55-11-8166-5050; fax: +55-11-5052-0386,
Email: nelson.hossne@gmail.com


Apelin helps heart function after bone marrow transplant

Apelin, a newly described inotropic peptide (related to the force of heart muscle contraction) with important cardiovascular regulatory properties, contributes to functional improvement in patients with severe heart failure after they have undergone implantation with bone marrow mononuclear cells (BMMC). The study, carried out at the Navy General Hospital in Beijing, evaluated 40 patients with severe heart failure following myocardial infarction. Twenty patients were assigned to receive BMMC transplants and 20 received standard medication. Another 20 healthy patients were assigned as controls.

"Baseline levels of plasma apelin were significantly lower in all heart failure patients as compared to normal, healthy subjects," said corresponding author Dr. Lian Ru Gao. "However, in patients who underwent cell transplantation, apelin increased significantly from three to 21 days post-transplantation. This increase in apelin was also followed by significant improvement in cardiac function."

In patients who received standard treatment, there was no increase in apelin.

According to the researchers, apelin, known to be a potent inotropic agent, was recently recognized as an important regulator of myocardial cell specification and heart development. In addition, reports that apelin concentration decreased with heart function impairment led the researchers to hypothesize that bone marrow transplantation might play a role in improving heart function by releasing apelin.

"Our objective was to assess how apelin plasma levels changed post-transplantation as well as to determine the relationship between increased apelin levels and heart function," added Dr. Gao.

Apelin levels increased in all patients who received BMMCs, and cardiac function improved as reflected by the relief of dyspnea and other measures, and so the researchers concluded that apelin signaling may play an important role in the heart function improvement observed after BMMC transplantation.

"Increased apelin levels may act as a paracrine mediator produced from BMMCs and may play an important role in the treatment of heart failure through autocrine and paracrine mechanisms," Dr. Gao concluded.

"Both studies demonstrate a possible mechanistic approach in a clinical trial either via the role of monocytes or Apelin to improve cardiac function" said Dr. Amit Patel associate professor of surgery at the University of Utah School of Medicine and the cardiovascular, skin, other tissue section editor of Cell Transplantation ."These important findings further enhance the understanding of the use of bone marrow derived cell therapy for the treatment of cardiovascular disease.".

Contact: Dr. Lian Ru Gao, Department of Cardiology, Navy General Hospital, 6 Fucheng Road, Beijing 100037, China.
Tel: 011-86-10-88180197; fax: 011-86-10-68780127043,
Email: lianru@yahoo.com.cn


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Anorexics found to have excess fat-- in their bone marrow
2. MSU researcher links diabetic complication, nerve damage in bone marrow
3. Gene mismatch influences success of bone marrow transplants
4. Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue
5. Multiple route bone marrow stem cell injections show promise to treat spinal cord injury
6. Biomedical researchers create artificial human bone marrow in a test tube
7. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
8. NC State first university in nation to offer canine bone marrow transplants
9. Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
10. Researchers engineer pancreatic cell transplants to evade immune response
11. High blood sugars impact on immune system holds clues to improving islet cell transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016  Based on ... Frost & Sullivan recognizes US-based Intelligent Retinal Imaging ... & Sullivan Award for New Product Innovation. IRIS, ... North America , is poised ... rapidly growing diabetic retinopathy market. The IRIS technology ...
(Date:2/1/2016)... , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces ... personality, Joey Fatone . Las Vegas , ... --> Las Vegas , where Joey appeared ... The new video ad was filmed at the Consumer Electronics Show ... the Wocket booth to meet and greet fans. ...
(Date:1/25/2016)... BELL, Pa. , Jan. 25, 2016   Unisys Corporation ... recognition system at John F. Kennedy (JFK) International Airport, ... Border Protection (CBP) identify imposters attempting to enter ... do not belong to them. pilot testing of ... out initially at three terminals at JFK during January 2016. ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of its new stem cell treatment clinic in Quito, Ecuador. The new facility ... and trauma applications to patients from around the world. , The new ...
(Date:2/10/2016)... NX Prenatal Inc., a US based ... for early warning of adverse pregnancy outcomes, announced ... by Dr. Thomas McElrath of Brigham ... Medicine,s (SMFM) annual meeting held in ... The presentation reported initial positive top-line results regarding ...
(Date:2/10/2016)...  Allergan plc (NYSE: AGN ) a leading ... , Allergan,s CEO and President, will be featured as ... the RBC Capital Markets Healthcare Conference on Tuesday, February ... York Palace Hotel in New York, NY ... can be accessed on Allergan,s Investor Relations web site ...
(Date:2/10/2016)... ... 2016 , ... LATHAM, NEW YORK... Marktech Optoelectronics will feature their ... in San Francisco’s Moscone Center from February 16-18, 2016, and at the healthcare-focused BiOS ... InGaAs PIN diode standard packages feature a TO-46 metal can with active areas of ...
Breaking Biology Technology: