Navigation Links
Bonding together to fight HIV
Date:11/24/2013

(BOSTON, MA) A collaborative team led by a Northeastern University professor may have altered the way we look at drug development for HIV by uncovering some unusual properties of a human protein called APOBEC3G (A3G).

In an article published in Nature Chemistry, Prof. Mark Williams and his graduate student Kathy Chaurasiya, along with several collaborators, show how these unusual properties help us to fight HIV infection.

APOBEC3G

It is well known that in response to virus infection, the body makes specific antibodies to counteract the infection. However, we are also born with another way to fight infection, namely through the action of defense proteins that are always present in our system. These proteins provide the first line of defense against invading pathogens. For example, we are all potentially protected against HIV because we have an antiviral protein called A3G. However, HIV has evolved a strategy to circumvent the activity of this protein by tricking our cells into destroying our own A3G proteins. This is where Prof. Williams's research comes into play.

A MULTI-FUNCTIONAL PROTEIN

A3G moves along a DNA strand as part of its function as an enzyme, and when it reaches a particular one of the four bases in DNA, it chemically alters the DNA, causing HIV to mutate. This was originally thought to be the only way A3G blocks HIV infection. However, some researchers found that even when A3G could not chemically alter the DNA, it still inhibited HIV. To explain this, Prof. Williams's collaborator Dr. Judith Levin from NIH, together with postdoctoral fellow Dr. Yasumasa Iwatani, proposed that A3G forms a roadblock that prevents the virus from making a DNA copy of its genome, thereby stopping HIV replication. This would require A3G to be more slow-acting, yet because the protein normally has to move fast to perform its chemical function, there seemed to be an apparent contradiction in the experimental res
'/>"/>

Contact: Lori Lennon
l.lennon@neu.edu
617-680-5129
Northeastern University College of Science
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Fraunhofer and Continental come together when the dandelion rubber meets the road
2. PD map: Putting together the pieces of the Parkinsons puzzle
3. Institut Pasteur Korea -- DNDi come together for the fight against neglected diseases
4. Telecoupling pulls pieces of sustainability puzzle together
5. GSA, the Paleontological Society, and SEPM in STEPPE together
6. Kirk, Spock together: Putting emotion, logic into computational words
7. Were in this together: A pathbreaking investigation into the evolution of cooperative behavior
8. Recent studies bring fossils and genes together to piece together evolutionary history
9. Learning from each other -- growing together
10. Using data to fight malaria
11. Griffith joins the fight against pneumonia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... , May 5, 2015, NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, reminds investors ... Chief Technology Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA ... 5-7, 2015. The three-day conference is organized ... is speaking in is themed Global Fraud: Where is ...
(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3
... 18.3.2013 In the fruit fly Drosophila , the functions ... intertwined - among other things they are involved in neurotransmitter ... of Biochemistry showed for the first time that flies cannot ... also raises new questions as to its function. Anna Ziegler, ...
... 18, 2013 Labrys Biologics Inc., a company focused on ... lead the development of RN-307, a Phase 2 ready anti-CGRP ... M.D., Ph.D., joins Labrys as chief medical officer, along with ... of project management; Michele Bronson , Ph.D., ...
... Researchers at Albert Einstein College of Medicine of Yeshiva ... found that macrophages white blood cells that play a key ... and eliminate the body,s red blood cells (RBCs). The findings could ... red blood cell production is thrown out of balance. The study, ...
Cached Biology News:Blind flies without recycling 2Blind flies without recycling 3Labrys Biologics Announces Key Executive Appointments 2Labrys Biologics Announces Key Executive Appointments 3Labrys Biologics Announces Key Executive Appointments 4White blood cells found to play key role in controlling red blood cell levels 2White blood cells found to play key role in controlling red blood cell levels 3
(Date:5/27/2015)... The Academy of Model Aeronautics Foundation would ... Model Aviation Day. The third annual celebration will be August ... the model aviation hobby nation-wide and to introduce model flying ... 2,350 chartered clubs to celebrate the hobby and share it ... There will also be a local event at the AMA ...
(Date:5/27/2015)... May 27, 2015 The ALS ... via its wholly owned subsidiary, Anelixis Therapeutics , ... for ALS that targets the innate immune system. The ... Development Institute received from the 2014 social media phenomenon ... sum of $4 million raised directly by the Institute ...
(Date:5/27/2015)... , May 27, 2015  Two years after its ... hackers and citizen scientists, Oakland -based ... campaign promoting its mission to democratize science through a ... Photo ... Based out of the new ...
(Date:5/27/2015)... 27, 2015 The Medical Innovation Impact ... of regulation on medical innovation, has been developed at ... of Fairleigh Dickinson University’s ( FDU ) Rothman Institute ... pertains to new FDA (Food & Drug Administration) ... the approval of certain medical devices. , “The ...
Breaking Biology Technology:Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 2Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 3Ice Bucket Challenge Advances Antibody Toward Clinical Trial for ALS 2Ice Bucket Challenge Advances Antibody Toward Clinical Trial for ALS 3East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 2East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 3Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2
... how to make an exact cut on a metal rod. But ... carbon nanotube, with a diameter 1/50,000th the thickness of a human ... journal Proceedings of the Royal Society A , researchers at ... single-walled carbon nanotubes are cut, a finding that could lead to ...
... /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: ... previously announced public offering of 25,000,000 common shares of ... US $37,650,000. In connection with the offering, the Company ... up to 3,750,000 additional common shares to cover over-allotments, ...
... Dec. 17, 2010 InterMune, Inc. (Nasdaq: ... team to prepare for the commercialization of Esbriet™ (pirfenidone) ... received a positive CHMP opinion that is now awaiting ... Chairman, Chief Executive Officer and President of InterMune, said, ...
Cached Biology Technology:How do you cut a nanotube? Lots of compression 2YM BioSciences Closes Public Offering of Common Shares 2YM BioSciences Closes Public Offering of Common Shares 3InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 2InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 3InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 4InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 5InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 6
...
... BD PhosFlow Perm/Wash Buffer I can be ... signaling proteins to permeabilize cells and to ... wash buffer. Because saponin-mediated cell permeabilization is ... keep the cells in the presence of ...
... Mouse polyclonal antibody raised against ... Immunogen: PPP4C ... a.a) partial recombinant protein with ... Accession Number: NM_002720 ...
... Thermomixer R offers maximum application versatility ... heating, and cooling. Its active heating/cooling ... and temperature control ranges. Five different ... micro test tubes, are available for: ...
Biology Products: