Navigation Links
Body's own proteins may lead the way in global fight against tuberculosis
Date:6/1/2010

Ohio scientists hope to counter the re-emerging threat of tuberculosis (TB) with help from proteins from our bodies. In a research report published in the June 2010 print issue of the Journal of Leukocyte Biology (http://www.jleukbio.org), scientists show how the protein CCL5 plays a protective role in helping the body ward off this contagious, airborne disease in the early stages of infection. CCL5 is a member of a large family of proteins responsible for immune cell migration toward infection sites. The work on this molecule suggests that CCL5 and/or related proteins may lead to new therapies that help the immune system resist TB.

"We hope this study will spark interest in understanding the mechanisms which control cell migration to sites of infection, help define the protective immune response to Mycobacterium tuberculosis, and ultimately improve our capacity to predict and/or treat patients with TB," said Gillian Beamer, V.M.D, Dipl. ACVP, Ph.D., a researcher from the Center for Microbial Interface Biology at Ohio State University in Columbus, Ohio who was involved in the work.

Scientists discovered the role and potential benefits of CCL5 by studying mice lacking the gene to make the CCL5 protein and mice with the CCL5 gene. When both groups of mice were infected with Mycobacterium tuberculosis, those lacking CCL5 accumulated fewer protective cells and had more bacteria in the lungs over three to five weeks of infection when compared to the normal mice. After five weeks, differences between the groups were not apparent, leading researchers to conclude that CCL5 did not play a role in long-term infection, but rather in the onset and early protection against infection. Additionally, in humans, altered CCL5 expression may be a predisposing factor leading to TB disease progression.

"Tuberculosis may not be top of mind for most people in the developed world, but TB is a leading cause of global disease and drug resistant forms of TB are an ever increasing problem," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Studies such as these this give us hope that as organisms evolve resistance to current therapies, we can develop promising new approaches to treat infectious disease."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
3. Depression, aging, and proteins made by a virus may all play role in heart disease
4. New approach builds better proteins inside a computer
5. Legionnaires bacterial proteins work together to survive
6. Proteins pack tighter in crowded native state
7. MIT IDs proteins key to brain function
8. Cystic fibrosis proteins photographed interacting
9. Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins
10. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
11. Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... DUBAI , UAE, April 20, 2016 ... can be implemented as a compact web-based "all-in-one" system ... in the biometric fingerprint reader or the door interface ... requirements of modern access control systems. The minimal dimensions ... the ID readers into the building installations offer considerable ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
(Date:3/31/2016)... PROVIDENCE, R.I. , March 31, 2016  Genomics ... leadership of founding CEO, Barrett Bready , M.D., ... addition, members of the original technical leadership team, including ... Vice President of Product Development, Steve Nurnberg and Vice ... have returned to the company. Dr. Bready ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Prairie, WI (PRWEB) , ... June 23, 2016 ... ... consultancy focused on quality, regulatory and technical consulting, provides a free webinar ... is presented on July 13, 2016 at 12pm CT at no charge. , ...
(Date:6/23/2016)... , June 22, 2016  Amgen (NASDAQ: ... the QB3@953 life sciences incubator to accelerate ... The shared laboratory space at QB3@953 was created to ... key obstacle for many early stage organizations - access ... the sponsorship, Amgen launched two "Amgen Golden Ticket" awards, ...
(Date:6/22/2016)... DIEGO , June 22, 2016 ... that will allow them to produce up to ... from one lot within one week. These high-quality, ... time laboriously preparing cells and spend more time ... possible through a proprietary, high-volume manufacturing process that ...
(Date:6/22/2016)...  According to Kalorama Information, the dominant trends ... include significant efforts in automation as well as ... affordable sequencers, say the healthcare market research firm, ... sample prep materials.  The healthcare market research company,s ... Next Generation Sequencing (NGS) , highlights major trends ...
Breaking Biology Technology: