Navigation Links
Body's anti-HIV drug explained
Date:10/12/2008

Humans have a built-in weapon against HIV, but until recently no one knew how to unlock its potential.

A study published online by the journal Nature reveals the atomic structure of this weapon an enzyme known as APOBEC-3G and suggests new directions for drug development.

APOBEC-3G is present in every human cell. It is capable of stopping HIV at the first step of replication, when the retrovirus transcribes its RNA into viral DNA.

The study's authors, led by Xiaojiang Chen of the University of Southern California, were able to show the atomic structure of the active portion of APOBEC-3G.

The discovery suggests how and where the enzyme binds to the viral DNA, mutating and destroying it.

"We understand how this enzyme can interact with DNA," said Chen, a professor of molecular and computational biology at USC. "This understanding provides a platform for designing anti-HIV drugs."

If APOBEC-3G works so well, why do people get AIDS? Because the HIV virus has evolved to encode the protein Vif, known as a "virulence factor," that blocks APOBEC-3G.

With APOBEC-3G out of the way, the RNA of the HIV virus can be successfully transcribed to viral DNA, an essential step for infection and for producing many more HIV viruses.

Chen said his group's research offers important clues on where Vif binds to APOBEC-3G. The knowledge could be used to design drugs that would prevent Vif from binding and allow APOBEC-3G to do its job, Chen said.

That would unlock humans' innate ability to fight HIV.

"We were born with it, and it's there waiting," Chen said.

In addition to fighting HIV, APOBEC-3G can inhibit the Hepatitis B virus. Other members of the APOBEC family serve important roles in antibody maturation, fat metabolism and heart development.

Mapping the structure of APOBEC-3G at the atomic level is a goal that "has been sought after worldwide because of its signifi
'/>"/>

Contact: Carl Marziali
marziali@usc.edu
213-219-6347
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Anti-HIV therapy boosts life expectancy more than 13 years
2. Genes newly explained effect on height may change tumor disorder treatment
3. Bodily breakdown explained: How cell differentiation patterns suppress somatic evolution
4. Primate behavior explained by computer agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Institutes of Health (NIH) awarded Lawrence Livermore National ... electrode array system that will enable researchers to ... resolution and scale. , LLNL,s grant-funded project is ... BRAIN (Brain Research through Advancing Innovative Neurotechnologies) ... our understanding of the human mind and uncover ...
(Date:9/30/2014)... of environmental scientists and engineers, led by Clemson ... three-year, $5.25 million grant from the U.S. Department ... to make a direct positive impact on South ... disposal of radioactive contaminants. , "Understanding the scientific ... with environmental aspects of nuclear technologies is imperative ...
(Date:9/30/2014)... New England Journal of Medicine reports positive results ... crizotinib against the subset of lung cancer marked by ... of 50 patients with advanced non-small cell lung cancer ... was 72 percent, with 3 complete responses and 33 ... takes for the disease to resume its growth after ...
Breaking Biology News(10 mins):NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Researchers get $5.25 million to advance nuclear technologies in South Carolina 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
... Calif. Researchers at Sandia National Laboratories will use ... high-throughput assays as part of a multiproject, $34 ... (ARPA-E) aimed at developing advanced biocatalyst technologies that ... transportation. The ARPA-E program is Reducing Emissions ...
... scientific team has discovered a gene associated with a ... variant may be an actual cause of this form ... children. "Because asthma is a complex disease, with ... recurrent asthma occurring between ages two and six," said ...
... OVERVIEW: Straight from Stockholm: Randy Schekman, Ph.D., ... New Orleans after receiving the 2013 Nobel Prize in ... 2,500 poster presentations about the latest research on cellular ... cell interactions and the proverbial much, much more. ...
Cached Biology News:Converting natural gas to liquid transportation fuels via biological organisms 2Converting natural gas to liquid transportation fuels via biological organisms 3Novel gene variant found in severe childhood asthma 2
(Date:9/30/2014)... 30, 2014 BioHealth Innovation, Inc. ... biohealth innovations and increasing access to early-stage funding in ... venture capitalist, Tania Fernandez , Ph.D., has joined ... will be a member of the management team for ... to $50 million in seed and early-stage equity investments ...
(Date:9/30/2014)... 2014 The custom stainless steel fabrication ... Show 2014. The Boston Area Chapter of ISPE (International ... day-long event for Wed., Oct. 1 at Gillette Stadium ... the largest in ISPE Boston’s long history, with more ... attendees expected. , HOLLOWAY AMERICA President David Simpson ...
(Date:9/30/2014)... 30, 2014 On September 11, Pharma IQ ... in anticipation of a session that he will lead on ... scheduled for February 17-18, 2015 in London. In the ... asked Dr. Sherley to respond to several questions on the ... to evaluating stem cell toxicity, and future trends in the ...
(Date:9/30/2014)... September 30, 2014 The ... IACRN), a non-profit organization based in Pittsburgh, Pennsylvania, ... and Safety (ACRES), a Massachusetts non-profit charitable ... alliance agreement, setting the stage for multiple collaborative ... clinical research quality and safety through specialized nursing ...
Breaking Biology Technology:Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3
... technologys sake. And yet a visiting space alien that is ... for believing thats what most of us are doing. We ... the technology and almost none of our energy into assessing ... From the way we allocate our energy and attention, it ...
... MADISON, Wis. — With the University of Wisconsin System ... of creating two separate statewide networks, Gov. Jim Doyle ... efforts. , ,"It's more sensible for taxpayers to have ... spokesperson Dan Leistikow. , ,Initial discussions last year about ...
... a new product, behave just like parents jumping in ... of the incubation wing is often replaced by a ... Dilbertish style revolution. Objects do fly, even though they ... Everyone shares the excitement and all fights are well ...
Cached Biology Technology:Why are you buying technology? 2Why are you buying technology? 3Governor tells UW to scrap network plans 2Naming that thing... again? 2Naming that thing... again? 3Naming that thing... again? 4
... Price (1996) • This issue ... chemistry and the purification and ... on the following procedures is ... amino acid analysis and the ...
Edited by D.M. Gersten (1996) Provides comprehensive descriptions of the techniques available for analytical gel electrophoresis of proteins and offers clear step-by-step protocols for all of the m...
...
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
Biology Products: