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Body weight influenced by thousands of genes
Date:1/14/2008

of genes in the mouse genome, this implies that over 6,000 genes could potentially contribute to the body weight of a mouse.

Tordoff comments, It is interesting that there are 10 times more genes that increase body weight than decrease it, which might help explain why it is easier to gain weight than lose it.

Because body weight plays a role in many diseases, including hypertension, diabetes, and heart disease, the implications of the findings extend beyond studies of obesity and body weight. Gene knockouts reported to affect these diseases and others could potentially be due to a general effect to lower body weight.

The findings also hold clinical relevance, according to lead author Danielle R. Reed, PhD, a Monell geneticist. "Clinicians and other professionals concerned with the development of personalized medicine need to expand their ideas of genetics to recognize that many genes act together to determine disease susceptibility."


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Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center
Source:Eurekalert

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Deletions, insertions or substitutions. Mutations in plasmids of size up to 15 kb. Single or multiple mutations...
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