Navigation Links
Body weight influenced by thousands of genes
Date:1/14/2008

PHILADELPHIA (January 14, 2008) Reporting in the online journal BMC Genetics, researchers from the Monell Center have for the first time attempted to count the number of genes that contribute to obesity and body weight.

The findings suggest that over 6,000 genes about 25 percent of the genome help determine an individuals body weight.

Reports describing the discovery of a new obesity gene have become common in the scientific literature and also the popular press, notes Monell behavioral geneticist Michael G. Tordoff, PhD, an author on the study.

Our results suggest that each newly discovered gene is just one of the many thousands that influence body weight, so a quick fix to the obesity problem is unlikely.

To obtain an estimate of how many genes contribute to body weight, the Monell researchers surveyed the Jackson Laboratory Mouse Genome Database for information on body weights of knockout mouse strains.

Knockout mice have had a specific gene inactivated, or "knocked out. By studying how the knockout mice differ from normal mice, researchers obtain information about that genes function and how it might contribute to disease. Mice can provide valuable information on human disease because they share many genes with humans.

The knockout approach is so useful that the inventors of the technology were awarded the 2007 Nobel Prize in Medicine. Knockout mice are now standard tools in all mouse models of behavior and disease.

In 60% of strains, knocking out a gene produces mice that are nonviable; that is, the mouse cannot survive without the knocked out gene.

The Monell survey revealed that body weight was altered in over a third of the viable knockout stains; 31 percent weighed less than controls (indicating that the missing genes contribute to heavier body weight), while another 3 percent weighed more (contributing to lighter weight).

Extrapolating from the total number
'/>"/>

Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Weight loss -- not one size fits all
2. Lush or lightweight?
3. Knocking out cell receptor may help block fat deposits in tissues, prevent weight gain
4. Exercise improves thinking, reduces diabetes risk in overweight children
5. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
6. New drug makes weight loss safer
7. Weight gain between first and second pregnancies associated with increased odds of male second child
8. Soft drinks alone do not affect childrens weight
9. Mice stressed in simulated weightlessness show organ atrophy
10. How mother of thousands makes plantlets
11. Thousands of starving children could be restored to health with peanut butter program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... 18, 2015 Fingerprint Cards (FPC) has ... FPC1145, FPC1155 and FPC1035 from one if its module partners. ... including Q3 2015 and the sensors will be used by ... values for 2015 hereby amount to 740 MSEK to date. ... 140 MSEK and a number of smaller orders not separately ...
(Date:5/14/2015)... , May 14, 2015  Verificient ... identity verification and online remote proctoring, announced ... software-as-a-service (SaaS) company and creator of the ... of the two companies will benefit from ... Canvas. As a fully integrated ...
(Date:5/8/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), the ... of the executive management team will present at the following ... and Telecom Conference Date: May 18, 2015 Time: ... MA Cowen and Company Technology, Media ... Location: The New York Palace Hotel, New York, ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Synaptics to Present at Upcoming Investor Conferences 2
... The 2009 American Society for Microbiology (ASM) ICAAC ... M. Hohl, Assistant Professor, Vaccine and Infectious Diseases ... Professor, Division of Allergy and Infectious Diseases, University ... Health, this award recognizes early career scientists for ...
... What steps have public officials in your state or ... American adolescents who are obese has tripled in just 35 ... that make it either easy or hard for families to ... eat healthy and be physically active. LOCAL GOVERNMENT ACTIONS TO ...
... The University of Texas Health Science Center at Houston ... cardiovascular indications including heart disease may produce large amounts ... by scientists in the university,s Brown Foundation Institute of ... appear in the Sept. 15 print issue of the ...
Cached Biology News:Tackling childhood obesity at the local level -- IOM report releases Sept. 1 2Scientists help explain effects of ancient Chinese herbal formulas on heart health 2
(Date:5/21/2015)... Imagine being able to probe ... of others. Being able to read faces and enjoy ... to anticipate their thoughts and actions like never before. ... to create unique abstract paintings and video, or, play ... a first-person-shooter as it creates action, dialog, and outcomes ...
(Date:5/21/2015)... 2015 As part of its philanthropic ... Sun Health Foundation funded a $3.25 million project to ... with the most up-to-date features and technology. , The ... pharmacy's 45 staff members will begin moving from the ... the coming days. , The current pharmacy has ...
(Date:5/21/2015)... PA (PRWEB) May 21, 2015 ... has joined the firm as senior statistician and Principal, ... years of experience in the management and analysis of ... pharmaceutical and chemical industries. , “We’re delighted to have ... capabilities in data analytics,” said Dr. Philippe Cini, Group ...
(Date:5/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/qfxkcq/global_cell ... Cell Therapy Market Outlook 2020 " report to ... tissue and regenerative medicine is expected to have huge ... could help in the growth of deregulated organs. Several ... are unable to form new tissue or sometimes organ ...
Breaking Biology Technology:5 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 2Sun Health Foundation Provides $3.25M to Expand, Relocate Banner Del E. Webb Medical Center Pharmacy 3Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3
... have developed a new type of small-scale electric power ... stretching and releasing of zinc oxide wires encapsulated in ... , The new "flexible charge pump" generator is ... current by using the piezoelectric properties of zinc oxide ...
... 7 In refusing to a request for ... replacement of its,current directors, management of Trinity Biotech ... manufacturer of diagnostic products whose,American Depository Receipts ("ADRs) ... preservation of their jobs and positions in the ...
... BRISBANE, Calif., Nov. 7 InterMune, Inc.,(Nasdaq: ITMN ... Officer and President of InterMune, will present at Deutsche,Bank,s ... 4:00 p.m. EST., To access a live audio ... log on to the investor relations page of InterMune,s,corporate ...
Cached Biology Technology:New small-scale generator produces alternating current by stretching zinc oxide wires 2New small-scale generator produces alternating current by stretching zinc oxide wires 3Trinity Biotech Management Refuses to Honor Call for a Special Meeting of Shareholders 2Trinity Biotech Management Refuses to Honor Call for a Special Meeting of Shareholders 3
Request Info...
Request Info...
Penicillin-Streptomycin liquid...
Streptomycin sulfate an aminoglycoside used for bacterial selection binds to the small ribosomal subunit and interferes with protein biosynthesis.21H39N7O12)2x3H2SO4Formula weight:...
Biology Products: