Navigation Links
Body mass index may predict heart disease risk for type-2 diabetic patients new study finds

DALLAS Researchers from the Intermountain Medical Center Heart Institute, in collaboration with researchers from Johns Hopkins University and the National Institutes of Health, have discovered a simple way to further predict a diabetic patient's risk for heart disease: by measuring their body mass index or BMI.

The Intermountain Medical Center Heart Institute study is part of a larger study called faCTor-64, which is a landmark, randomized trial designed to determine if using CT scans to screen for heart disease in diabetic patients who don't have heart disease symptoms can help save lives.

As Intermountain researchers measured coronary artery plaque buildup in study participants, they discovered that a major controllable predictor of heart disease was BMI. Simply put: the greater the patient's BMI, the greater their risk for heart disease.

Researchers will present this study at the 2013 American Heart Association Scientific Sessions in Dallas, on Nov. 17 at 10 am, ET.

"Our study shows there's a strong linear relationship between BMI and plaque volume and composition," said J. Brent Muhlestein, MD, lead researcher and co-director of cardiovascular research at the Intermountain Medical Center Heart Institute in Murray, Utah. "So even being a little overweight is associated with more plaque, while being obese is associated with a lot of plaque."

Researchers say the findings are significant because heart disease causes about 75% of deaths in patients who have diabetes, but not everyone has obvious risk factors, such as smoking, high glucose levels, high cholesterol levels, or high blood pressure.

Patients with obvious risk factors can be treated, but for the patients who don't have obvious risk factors, their first indictor of heart disease is often in the form of a heart attack or stroke or even death.

Current methods to measure plaque buildup are invasive and costly, and are not used to screen patients who don't display signs of heart disease. However, the coronary computed tomography angiography (CCTA) offers a new, and less invasive way to screen these patients for heart disease.

"It may be that in diabetic patients without any symptoms of heart disease, their BMI could be used to determine if they need a CT scan to screen for plaque buildup," said Muhlestein. "We could then develop a treatment plan for at-risk patients.

Findings from the study may also change the way diabetic patients are treated. Current diabetic management strategies include three options:

  • Insulin-sensitizing medication to help the body's tissues become more sensitive to insulin and decrease glucose production
  • Insulin-stimulating therapy to increase the pancreas' production of insulin
  • Insulin injections

When patients are treated with insulin therapy and injections, they commonly experience weight gain. "When you provide more insulin, it's associated in almost every study with increased weight gain," said Dr. Muhlestein.

While weight gain does not necessarily predict heart disease in non-diabetics, the findings of this study shows that weight gain in diabetics can indicate the buildup of plaque. This is significant because the degree of weight gain can be reduced by using other types of diabetic treatments, such as insulin sensitizing medication.

"Based on the findings of this study, choosing insulin sensitizing therapy, as the primary management strategy in diabetic patients may be beneficial by reducing the tendency towards elevated BMI's, said Dr. Muhlestein.

Not only will the results of this study help researchers better understand which treatments will reduce weight gain, but they will also help researchers predict who will get heart disease which will help physicians offer better long-term diabetic treatments to their patients.

"Our goal at the Intermountain Medical Center Heart Institute, is to learn how to predict who will get heart disease, so we can provide the best care possible and improve long-term outcomes rather than waiting until a person has a heart attack or even dies," he said.


Contact: Jess C. Gomez
Intermountain Medical Center

Related biology news :

1. 2013 Ocean Health Index shows food provision remains an area of great concern
2. Body mass index of low income African-Americans linked to proximity of fast food restaurants
3. Increasing evidence links high glycemic index foods and dairy products to acne
4. The Phosphorus Index: Changes afoot
5. Glycemic index foods at breakfast can control blood sugar throughout the day
6. Danish researchers predict risk of valvular heart disease
7. Gut hormone test predicts individual efficacy of gastric bypass
8. VC predicts the motion of the ocean
9. Measuring segments of genetic material may help predict and monitor recurrence after thyroid cancer
10. Predicting the life expectancy of solar modules
11. Historic trends predict future global reforestation unlikely
Post Your Comments:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
(Date:4/28/2016)... First quarter 2016:   , ... the first quarter of 2015 The gross margin was ... 18.8) and the operating margin was 40% (-13) Earnings ... flow from operations was SEK 249.9 M (21.2) , ... SEK 7,000-8,500 M. The operating margin for 2016 is ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
Breaking Biology Technology: