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Body mass index and thrombogenic factors in newly menopausal women
Date:8/27/2010

ment therapy or placebo in the KEEPS. The researchers divided the 118 women into three groups according to BMI, with women in the low, moderate, and high groups having BMIs of less than 25, 25 to 29.9, and 30 to 34.9 respectively. The researchers assessed conventional cardiovascular risk factors such as blood pressure, cholesterol, triglycerides, fasting blood glucose, and liver function. They also analyzed the women's blood for platelet count, platelet reactivity, populations of activated cell membrane-derived thrombogenic microvesicles, and the amount of high-sensitive C-reactive protein and activated protein C. Finally, the women underwent computer tomography scans to test for the presence of calcium in their coronary arteries, an indicator of cardiovascular disease.

Results

Although most of the conventional risk factors were in the normal range in all of the women, the researchers found that these parameters were significantly greater in the moderate and high BMI groups compared to the low BMI group. For example, the mean blood pressure in the low BMI group was 115/72 mmHg, but 124/77 mmHg and 127/78 mmHg in the moderate and high BMI groups, respectively. Likewise, mean fasting blood glucose was 89 mg/dL in the low BMI group, but 92 mg/dL and 95 mg/dL in the moderate and high BMI groups. The exception was LDL, which was normal in the low BMI group with a mean of 122 mg/dL, but borderline high in the moderate and high BMI groups, each having a mean of 138 mg/dL and 140 mg/dL, respectively.

The researchers found elevated levels of platelets, thrombogenic microvesicles, high-sensitive C-reactive protein, and activated protein C in the moderate and high BMI groups. The mean platelet count in the low BMI group was 220 x103/L, but 233 x103/L and 255 x103/L in the moderate and high BMI groups, respectively. Mean high-sensitive C-reactive protein in the low group was 1 pg/mL, but 2 pg/mL in the moderate BMI group and 4 pg/mL in the hig
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Contact: Donna Krupa
DKrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

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