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Body mass index and thrombogenic factors in newly menopausal women

Westminster, Colo. (August 27, 2010) Although having a high body mass index (BMI) is a known risk factor for cardiovascular disease, researchers are only beginning to understand how BMI affects the physiological processes involved in the development of the disease. Now, a study of a subset of women in the Kronos Early Estrogen Prevention Study (KEEPS), suggests that as BMI increases, so do platelet reactivity and thrombogenic microvesicles and activated protein C in the bloodall of which contribute to the formation of atherothrombosis and associated cardiovascular events. Moreover, as BMI increases, so do traditional established cardiovascular risk factors such as blood pressure, blood glucose, total cholesterol, LDL cholesterol, triglycerides, and high-sensitive C-reactive protein.

Muthuvel Jayachandran, Assistant Professor of Physiology in the Mayo Clinic's Department of Physiology and Biomedical Engineering in Rochester, Minn., is the lead author of the study which is entitled, "Body Mass Index and Thrombogenic Factors in Newly Menopausal Women." He will present his team's findings at the 2010 American Physiological Society (APS) conference, Inflammation, Immunity, and Cardiovascular Disease, in Westminster Colorado, August 25-28. The full conference program can be found at

The Study

The Mayo researchers assessed cardiovascular risk factors in 118 women newly enrolled in the KEEPS, an ongoing multicenter study designed to evaluate the effectiveness of hormone replacement therapy in preventing cardiovascular disease in newly post-menopausal women aged 42 to 58. All women in the study had their final menstrual period less than 36 months prior to enrollment.

The Mayo subset study is a baseline study that determined cardiovascular risk parameters in women before they were randomized to receive hormone replace

Contact: Donna Krupa
American Physiological Society

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