Navigation Links
Body mass index and thrombogenic factors in newly menopausal women
Date:8/27/2010

Westminster, Colo. (August 27, 2010) Although having a high body mass index (BMI) is a known risk factor for cardiovascular disease, researchers are only beginning to understand how BMI affects the physiological processes involved in the development of the disease. Now, a study of a subset of women in the Kronos Early Estrogen Prevention Study (KEEPS), suggests that as BMI increases, so do platelet reactivity and thrombogenic microvesicles and activated protein C in the bloodall of which contribute to the formation of atherothrombosis and associated cardiovascular events. Moreover, as BMI increases, so do traditional established cardiovascular risk factors such as blood pressure, blood glucose, total cholesterol, LDL cholesterol, triglycerides, and high-sensitive C-reactive protein.

Muthuvel Jayachandran, Assistant Professor of Physiology in the Mayo Clinic's Department of Physiology and Biomedical Engineering in Rochester, Minn., is the lead author of the study which is entitled, "Body Mass Index and Thrombogenic Factors in Newly Menopausal Women." He will present his team's findings at the 2010 American Physiological Society (APS) conference, Inflammation, Immunity, and Cardiovascular Disease, in Westminster Colorado, August 25-28. The full conference program can be found at http://the-aps.org/meetings/aps/inflammation/.

The Study

The Mayo researchers assessed cardiovascular risk factors in 118 women newly enrolled in the KEEPS, an ongoing multicenter study designed to evaluate the effectiveness of hormone replacement therapy in preventing cardiovascular disease in newly post-menopausal women aged 42 to 58. All women in the study had their final menstrual period less than 36 months prior to enrollment.

The Mayo subset study is a baseline study that determined cardiovascular risk parameters in women before they were randomized to receive hormone replacement therapy or placebo in the KEEPS. The researchers divided the 118 women into three groups according to BMI, with women in the low, moderate, and high groups having BMIs of less than 25, 25 to 29.9, and 30 to 34.9 respectively. The researchers assessed conventional cardiovascular risk factors such as blood pressure, cholesterol, triglycerides, fasting blood glucose, and liver function. They also analyzed the women's blood for platelet count, platelet reactivity, populations of activated cell membrane-derived thrombogenic microvesicles, and the amount of high-sensitive C-reactive protein and activated protein C. Finally, the women underwent computer tomography scans to test for the presence of calcium in their coronary arteries, an indicator of cardiovascular disease.

Results

Although most of the conventional risk factors were in the normal range in all of the women, the researchers found that these parameters were significantly greater in the moderate and high BMI groups compared to the low BMI group. For example, the mean blood pressure in the low BMI group was 115/72 mmHg, but 124/77 mmHg and 127/78 mmHg in the moderate and high BMI groups, respectively. Likewise, mean fasting blood glucose was 89 mg/dL in the low BMI group, but 92 mg/dL and 95 mg/dL in the moderate and high BMI groups. The exception was LDL, which was normal in the low BMI group with a mean of 122 mg/dL, but borderline high in the moderate and high BMI groups, each having a mean of 138 mg/dL and 140 mg/dL, respectively.

The researchers found elevated levels of platelets, thrombogenic microvesicles, high-sensitive C-reactive protein, and activated protein C in the moderate and high BMI groups. The mean platelet count in the low BMI group was 220 x103/L, but 233 x103/L and 255 x103/L in the moderate and high BMI groups, respectively. Mean high-sensitive C-reactive protein in the low group was 1 pg/mL, but 2 pg/mL in the moderate BMI group and 4 pg/mL in the high BMI group. Mean activated protein C was 0.6 ng/mL in the low group, but 1 ng/mL in both the moderate and high BMI groups.

Finally, researchers assessed the risk of developing coronary artery calcium according to the number of women in each group who tested positive for it. Women in the low BMI group had an 8% risk, but women in the moderate and high BMI groups had a 17% and 14% risk, respectively

Implications

According Dr. Jayachandran, the upward trend in risk parameters among women in the moderate and high BMI groups should be taken seriously. "It indicates that there may be more risk for cardiovascular disease. Early menopause is a time to address life style changes that will reduce BMI and therefore, cardiovascular risk," he said.

He added that studies like KEEPS will be pivotal in clearing up the controversy surrounding menopausal hormone therapy and cardiovascular risk. Previous studies, such as the Women's Health Initiative and the Heart and Estrogen/Progestin Replacement Study, did not show any cardiovascular benefit, but the demographics in those studies were different.

"Those studies examined women with a mean age of 62 years. They were further away from their menopause before starting treatment, and the hormones may not reduce existing atherosclerosis," Dr. Jayachandran said. "We want to know how the hormone treatments might work early on to prevent the development of cardiovascular disease."


'/>"/>

Contact: Donna Krupa
DKrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Related biology news :

1. UNC study: Color-coded chart improves parents understanding of body mass index
2. Disease Models & Mechanisms -- selected for indexing in Medline
3. Autism Speaks on US Senate hearing on potential environmental health factors in autism
4. Thesis analyzes factors responsible for the case of Basque natural cider turning bitter
5. International study identifies 12 new genetic risk factors for type 2 diabetes
6. New 2009 Impact Factors soar for newest Cell Press journals
7. Grapes reduce risk factors for heart disease and diabetes, U-M animal study shows
8. Study pins factors behind geography of human disease
9. CNIC and Banco Santander set up research project on early cardiovascular risk factors
10. New genetic risk factors for aneurysms identified by Yale-led team
11. DYRK1A gene may be 1 of most influential factors in Down syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:4/14/2016)... AVIV, Israel , April 14, 2016 ... Behavioral Authentication and Malware Detection, today announced the appointment ... already assumed the new role. Goldwerger,s leadership ... BioCatch, on the heels of the deployment of its ... addition, BioCatch,s behavioral biometric technology, which discerns unique cognitive ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator ... Members of the Class of 2016 were selected from a pool of 128 ... About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the ... the Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s ... how hardware projects are designed, built and brought to market. , The Design ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the NASDAQ Composite ... Jones Industrial Average edged 0.27% lower to finish at 17,780.83; ... has initiated coverage on the following equities: Infinity Pharmaceuticals Inc. ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... more about these stocks by accessing their free trade alerts ...
Breaking Biology Technology: