Navigation Links
Body clock found to regulate platelet function
Date:9/9/2011

Boston, MA Researchers at Brigham and Women's Hospital (BWH) have demonstrated that the circadian system, the body's internal clock, regulates human platelet function and causes a peak in platelet activation corresponding to the known morning peak in adverse cardiovascular events. These findings are published in PLoS ONE on September 8, 2011.

"Cardiovascular disease is still the number one cause of death in developed countries, and we know major adverse cardiovascular events do not occur at random, but are more frequent in the morning," said lead author Frank Scheer, PhD, Assistant Professor of Medicine at the Division of Sleep Medicine at BWH. "Understanding the underlying factors for this morning peak in adverse events has the potential to address this pattern and decrease the risk."

In this study, the researchers demonstrated that the body clock regulates platelet function and causes a peak in platelet activation corresponding to the morning peak in adverse cardiovascular events such as myocardial infarction and stroke. A high level of platelet activation can lead to adverse cardiovascular events by influencing blood clotting. According to Scheer, this finding mimics the pattern of morning peaks in cardiovascular risk and tells us that platelet function is likely one of the factors that contributes to this morning peak in adverse cardiovascular events.

"Further study is required to test whether this circadian pattern in platelet activation, as demonstrated here in healthy subjects, is shifted in time or has different rhythm amplitude in people with cardiovascular disease," Scheer said.

The study used a forced desynchrony protocol during which required healthy young subjects to live on a 20-hour day for 12 cycles in a dim-light, time-free, and controlled environment. The design of this protocol allowed the isolation of the effect of the internal circadian timing system on platelet function, independent of effects
'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Circadian clocks in a blind fish
2. Manipulating plants circadian clock may make all-season crops possible
3. Repairing our inner clock with a 2-inch fish
4. Newly discovered molecule essential to resetting body clocks
5. Worlds smallest atomic clock on sale
6. A sleep strategy commonly used by night nurses throws off their circadian clocks
7. Discovery may lead to turning back the clock on ovarian cancer
8. Researchers discover compound with potent effects on biological clock
9. Babies biological clocks dramatically affected by birth light cycle
10. Plant clock gene also works in human cells
11. Scientists clock on to how sunlight shapes daily rhythms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... May 21, 2015 The Sync Project™ ... music for health, today announced a collaborative partnership with ... partnership will center on collaboration on original research, joint ... step in the collaboration, The Sync Project and BerkleeICE ... as Medicine" in the 2015-2016 academic year.  ...
(Date:5/19/2015)... Fingerprint Cards (FPC) has received an order for ... from one if its module partners. Deliveries are planned to ... the sensors will be used by smartphone manufacturers in ... amount to 740 MSEK to date. In addition to previously ... number of smaller orders not separately communicated amounting to more ...
(Date:5/18/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... -- In the middle of the South Pacific, about ... that soon will emerge as a model ecosystem, thanks ... by University of California, Berkeley, biologists. Moorea, home ... Research Station and France,s Centre de Recherches Insulaires et ...
... NEW YORK (Dec. 7, 2007) -- Alcohol triggers the ... the health and activity of brain cells, and new ... City sheds light on how that process occurs. ... The Journal of Neuroscience, may also edge scientists closer ...
... researchers at The University of Nottingham are teaming up ... region, to work on pioneering Sport PhD courses. ... the use of illegal performance-enhancing drugs in sports, and ... affordable. Theyre just two of seven collaborative ...
Cached Biology News:US-French research team to barcode an entire ecosystem 2US-French research team to barcode an entire ecosystem 3US-French research team to barcode an entire ecosystem 4Research reveals secrets of alcohol's effect on brain cells 2Research reveals secrets of alcohol's effect on brain cells 3
(Date:6/2/2015)... China Cord Blood Corporation (NYSE: CO ) ("CCBC," the ... leading provider of cord blood collection, laboratory testing, hematopoietic stem ... the Special Committee of the Company,s board of directors (the ... China ) Limited as its independent financial advisor, ... United States legal counsel and Maples & ...
(Date:6/2/2015)... 2, 2015 MGB Biopharma ... resistance problem  MGB Biopharma, a biopharmaceutical ... to address the major global problem of antibiotic ... stable intravenous (IV) formulation of MGB-BP-3, designed for the ... The intravenous formulation of MGB-BP-3 is ...
(Date:6/1/2015)...  Turing Pharmaceuticals AG announced that life sciences executive ... MSc,  has joined the company as president of ... holds a medical degree as well as a ... accomplishments in the pharmaceutical industry, and extensive clinical ... played a leadership role in numerous programs for ...
(Date:6/1/2015)... 1, 2015 GenomeDx Biosciences today ... platform, successfully classified various subtypes of bladder ... certain biomarkers, including one type associated with ... genomic signature has potential as a tool ... in patients with muscle-invasive bladder cancers (MIBC). ...
Breaking Biology Technology:China Cord Blood Corporation's Special Committee Appoints Independent Financial Advisor and Legal Counsel to Evaluate Non-binding "Going Private" Proposal 2China Cord Blood Corporation's Special Committee Appoints Independent Financial Advisor and Legal Counsel to Evaluate Non-binding "Going Private" Proposal 3MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 2MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 3Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 2Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 3GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 2GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 3GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 4
... on PMA Study, FORT LAUDERDALE, Fla., April ... IMDS) announced that on,April 16, 2008, the Company ... directors Jay Bendis, Patrick Gorman, and Sherman Lazrus.,These ... by outside,funding sources as a condition to such ...
... Products Including Novel Nucleoside Analogue; New ... CEO and Directors ... Board: MACM) announced today that on April 18, 2008 it ... novel therapeutics, with a portfolio of,clinical stage product candidates focused ...
... Used in Combination with Taxol and Paraplatin Will Become the, ... from ... Decision Resources, WALTHAM, Mass., April ... firms focusing on pharmaceutical and,healthcare issues, finds that surveyed oncologists say ...
Cached Biology Technology:Imaging Diagnostic Systems Accepts Resignations of Outside Directors 2Imaging Diagnostic Systems Accepts Resignations of Outside Directors 3MacroChem Acquires Virium Pharmaceuticals 2MacroChem Acquires Virium Pharmaceuticals 3MacroChem Acquires Virium Pharmaceuticals 4MacroChem Acquires Virium Pharmaceuticals 5Avastin Used in Combination with Drugs from Bristol-Myers Squibb Has Advantages in Survival Rates Over the Current Sales-Leading Therapy for Advanced Ovarian Cancer 2Avastin Used in Combination with Drugs from Bristol-Myers Squibb Has Advantages in Survival Rates Over the Current Sales-Leading Therapy for Advanced Ovarian Cancer 3
... The carbohydrate analysis standard is ... and a sugar alcohol; molecular weights ... standard is provided for use with ... carbohydrate analysis kit for column testing ...
... kit was tested on rat tissue extracts (liver, ... ( S. cerevisae ) extract. It was also ... and cell lines. Application: A simple and reliable ... based on the detection of the inorganic phosphate ...
... condition in which a lack of balance ... various antioxidants. Oxidative stress appears to ... diseases, including artherosclerosis, chronic inflammatory diseases, and ... systems that are very important for the ...
...
Biology Products: