Navigation Links
Body builders -- the worms that point the way to understanding tissue regeneration
Date:4/23/2010

Scientists at The University of Nottingham have discovered the gene that enables an extraordinary worm to regenerate its own body parts after amputation including a whole head and brain.

Their research into the Planarian worm is another piece in the scientific jigsaw that could one day make the regeneration of old or damaged human organs and tissues a real possibility.

The research led by Dr Aziz Aboobaker, a Research Councils UK Fellow in the School of Biology shows for the first time that a gene called 'Smed-prep' is essential for correctly regenerating a head and brain in planarian worms. The study is published on April 22 2010 in the open access journal PLoS Genetics.

Planarian worms have an amazing ability to regenerate body parts, including a head and brain, following amputation. These remarkable creatures contain adult stem cells that are constantly dividing and can become all of the missing cell types. They also have the right set of genes working to make this happen exactly as it should so that when they re-grow body parts they end up in the right place and have the correct size, shape and orientation.

Dr Aboobaker said: "These amazing worms offer us the opportunity to observe tissue regeneration in a very simple animal that can regenerate itself to a remarkable extent and does so as a matter of course.

"We want to be able to understand how adult stem cells can work collectively in any animal to form and replace damaged or missing organs and tissues. Any fundamental advances in understanding from other animals can become relevant to humans surprisingly quickly.

"If we know what is happening when tissues are regenerated under normal circumstances, we can begin to formulate how to replace damaged and diseased organs, tissues and cells in an organised and safe way following an injury caused by trauma or disease. This would be desirable for treating Alzheimer's disease, for example. With this knowledge we can also assess the consequences of what happens when stem cells go wrong during the normal processes of renewal for example in the blood cell system where rogue stem cells can result in Leukaemia."

Smed-prep is necessary for the correct differentiation and location of the cells that make up a planarian worm's head. It is also sufficient for defining where the head should be located on the worm. The team have found that although the presence of Smed-prep is vital so that the head and brain are in the right place, the worm stem cells can still be persuaded to form brain cells as a result of the action of other unrelated genes. But even so, without Smed-prep these cells do not organise themselves to form a normal brain.

Daniel Felix, a graduate student who carried out the experimental work said: "The understanding of the molecular basis for tissue remodeling and regeneration is of vital importance for regenerative medicine. Planarians are famous for their immense power of regeneration, being able to regenerate a new head after decapitation. With the homeobox gene Smed-prep, we have characterised the first gene necessary for correct anterior fate and patterning during regeneration. It has been a really exciting project and I feel very lucky to have had this study as the centre piece of my thesis work"


'/>"/>

Contact: Lindsay Brooke
lindsay.brooke@nottingham.ac.uk
44-115-951-5751
University of Nottingham
Source:Eurekalert

Related biology news :

1. Blood vessel builders
2. Brains, worms and computer chips have striking similarities
3. Bone-eating worms 30 million years old
4. Scientists find new genes for cancer, other diseases in plants, yeast and worms
5. More than fish bait: Worms unlock secrets to new epilepsy treatments
6. Pinhead-size worms + robot = new antibiotics
7. Parasitic worms make sex worthwhile
8. Ancient geologic escape hatches mistaken for tube worms
9. Key to curing obesity may lie in worms that destroy their own fat: McGill researchers
10. Deprived of a sense of smell, worms live longer
11. Floridas worm grunters collect bait worms by inadvertently imitating mole sounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... SAN FRANCISCO , June 16, 2016 /PRNewswire/ ... Market size is expected to reach USD ... report by Grand View Research, Inc. Technological proliferation ... and banking applications are expected to drive the ... ) , The development of ...
(Date:6/9/2016)... Paris Police Prefecture and ... ensure the safety of people and operations in several locations ... Teleste, an international technology group specialised in broadband ... its video security solution will be utilised by ... across the country. The system roll-out is scheduled for the ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight ... solutions to the healthcare market. The company's primary focus is on new product ... marketing strategies that are necessary to help companies efficiently bring their products to ...
(Date:6/27/2016)... Ginkgo Bioworks , a leading organism design company ... as one of the World Economic Forum,s Technology ... companies. Ginkgo Bioworks is engineering biology to manufacture ... the nutrition, health and consumer goods sectors. The ... Fortune 500 companies to design microbes for their ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... While ... machines such as the Cary 5000 and the 6000i models are higher end machines ... is the height of the spectrophotometer’s light beam from the bottom of the cuvette ...
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
Breaking Biology Technology: