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Body builders -- the worms that point the way to understanding tissue regeneration
Date:4/23/2010

Scientists at The University of Nottingham have discovered the gene that enables an extraordinary worm to regenerate its own body parts after amputation including a whole head and brain.

Their research into the Planarian worm is another piece in the scientific jigsaw that could one day make the regeneration of old or damaged human organs and tissues a real possibility.

The research led by Dr Aziz Aboobaker, a Research Councils UK Fellow in the School of Biology shows for the first time that a gene called 'Smed-prep' is essential for correctly regenerating a head and brain in planarian worms. The study is published on April 22 2010 in the open access journal PLoS Genetics.

Planarian worms have an amazing ability to regenerate body parts, including a head and brain, following amputation. These remarkable creatures contain adult stem cells that are constantly dividing and can become all of the missing cell types. They also have the right set of genes working to make this happen exactly as it should so that when they re-grow body parts they end up in the right place and have the correct size, shape and orientation.

Dr Aboobaker said: "These amazing worms offer us the opportunity to observe tissue regeneration in a very simple animal that can regenerate itself to a remarkable extent and does so as a matter of course.

"We want to be able to understand how adult stem cells can work collectively in any animal to form and replace damaged or missing organs and tissues. Any fundamental advances in understanding from other animals can become relevant to humans surprisingly quickly.

"If we know what is happening when tissues are regenerated under normal circumstances, we can begin to formulate how to replace damaged and diseased organs, tissues and cells in an organised and safe way following an injury caused by trauma or disease. This would be desirable for treating Alzheimer's disease, for example. With thi
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Contact: Lindsay Brooke
lindsay.brooke@nottingham.ac.uk
44-115-951-5751
University of Nottingham
Source:Eurekalert

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