Navigation Links
Bodily breakdown explained: How cell differentiation patterns suppress somatic evolution
Date:12/13/2007

Natural selection can occur at the cellular level, where it is detrimental to health. Fortunately it is normally controlled by a well-known pattern of ongoing cell differentiation in the mature tissues of animals, according to a new study published December 14 in PLoS Computational Biology.

The failure of normal cell differentiation patterns may explain cancer and senescent decline with aging, say researchers at the University of Arizona, the Santa Fe Institute, the University of Pennsylvania, and the Wistar Institute.

Darwinian natural selection and evolution is usually studied in populations of organisms, but it also applies to cellular populations; this is called somatic evolution. Such somatic evolution tends to reduce cooperation among cells, thus threatening the integrity of the organism.

In this study the authors proposed that a well-known pattern of ongoing cell differentiation in the mature tissues of animals functions to suppress somatic evolution, which is essential to the origin and sustainability of multicellular organisms.

The team, lead by Dr. John Pepper, tested this hypothesis using a computer simulation of cell population dynamics and evolution. The results were consistent with the hypothesis, suggesting that familiar patterns of ongoing cell differentiation were crucial to the evolution of multicellular animals, and remain crucial as a bodily defense against cancer.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers discover important tool in understanding differentiation in human embryonic stem cells
2. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
3. Interaction of just 2 genes governs coloration patterns in mice
4. Spatial patterns in tropical forests can help to understand their high biodiversity
5. New study uncovers secrets behind butterfly wing patterns
6. Can interacting pathogens explain disease patterns?
7. Bits of junk RNA aid master tumor-suppressor gene
8. Evolution is driven by gene regulation
9. Clones on task serve greater good, evolutionary study shows
10. Adaptation to parasites drive African fishes along different evolutionary paths
11. Uncertainty drives the evolution of cooperative breeding in birds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry news, ... website design. "When we launched FindBiometrics 12 years ... O,Neill , founder and CEO of FindBiometrics. "Now it,s maturing ... the key players on a very broad scale.  We are ...
(Date:1/22/2015)... 2015  BellBrook Labs, a leader in high throughput ... of a TR-FRET (time resolved Forster resonance energy ... a high throughput screening assay for glycosyltransferases and ... for sensitive detection of hundreds of human and ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... technology and tech stocks, releases video from the CES 2015 ... security consultant Apollo Robbins . Apollo shows ... Wocket™ biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... of cancer, including stomach, liver and colon, are far more ... that differences in lifestyle, such as diet and smoking, may ... differences are rooted in basic biological differences between men and ... MIT shows that treating male mice with estrogen dramatically lowers ...
... giant seaweeds, are spreading fast, with harmful effects on ... the Mediterranean seabed. Some native species, such as sea ... invasion, but only during its early stages, or when ... carried out a study to look at the ability ...
... salmon were to escape from captivity they could succeed ... Canadian researchers have found. Their research, published in ... GM salmon as they are considered for commercial farming. ... long been of interest to the aquaculture industry and ...
Cached Biology News:Study explains why men are at higher risk for stomach cancer 2Study explains why men are at higher risk for stomach cancer 3Sea urchins cannot control invasive seaweeds 2First study into GM Atlantic salmon mating reveals danger of escape to wild gene pool 2
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. ... company focused on advanced wound care, announces that ... tissues, have been added to the Premier, Inc. ... the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product ...
(Date:12/24/2014)... and NEW YORK , Dec. ... biopharmaceutical company advancing patient care in critical areas, announced the ... common stock, and warrants to purchase up to an aggregate ... $4.00 per share and $.01 per warrant.  The warrants have ...
(Date:12/24/2014)... 2014 “Preparative & Process Chromatography ... Consumables (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, ... - Forecasts to 2019” provides a detailed overview ... market trends, and strategies impacting the preparative and ...
(Date:12/24/2014)... 2014 SoundConnect’s 2015 ... cutting edge communication technology, provide continued education and ... webinar series demonstrates online communication features and benefits; ... conferencing’s most innovative and powerful tools. , According ...
Breaking Biology Technology:Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... fields to drive iron-bearing nanoparticles to metal stents in ... payload that successfully prevents blockages in those vessels. In ... at a lower dose than conventional non-magnetic stent therapy. ... is the latest in a series of studies at ...
... ... and xenograft response prediction. MM-111 breast cancer study in combination with trastuzumab. , ... Cambridge, MA (PRWEB) April ... on MM-121 and MM-111, the two lead candidates in the company’s pipeline of five ...
... Doctors could soon be prescribing a dose of dark ... from dangerously high blood pressure in their abdomen, according ... Liver CongressTM 2010, the Annual Meeting of the European ... According to the Spanish research, eating dark chocolate ...
Cached Biology Technology:Magnetic fields drive drug-loaded nanoparticles to reduce blood vessel blockages in an animal study 2Magnetic fields drive drug-loaded nanoparticles to reduce blood vessel blockages in an animal study 3Magnetic fields drive drug-loaded nanoparticles to reduce blood vessel blockages in an animal study 4Merrimack to Present Pre-Clinical Data on MM-121 and MM-111 at the 101st Annual Meeting of American Association for Cancer Research (AACR) 2Merrimack to Present Pre-Clinical Data on MM-121 and MM-111 at the 101st Annual Meeting of American Association for Cancer Research (AACR) 3Study shows potential benefit of dark chocolate for liver disease patients 2
... anti-phospho-FAK (Ser843) ... acid region encompassing the human, mouse, ... Accession Number: NM_153831 ... Routinely evaluated by immunoblot. ...
Molecular Biology grade. Ideally suited for DNA and RNA separation and recovery. High gel strength. Gelling temp. 36C. Melting temp. 88C. EEO: 0.05-0.13 Resolution 0.2-40 kb; Rnase/Dnase: none detec...
Rabbit polyclonal to Quinolinic acid ( Abpromise for all tested applications). Antigen: Synthetic quinolinic acid conjugated to bovine serum albumin....
Phospho-YAP (Ser127) Antibody Ship: Hot Store: -20 C...
Biology Products: