Navigation Links
Bodily breakdown explained: How cell differentiation patterns suppress somatic evolution
Date:12/13/2007

Natural selection can occur at the cellular level, where it is detrimental to health. Fortunately it is normally controlled by a well-known pattern of ongoing cell differentiation in the mature tissues of animals, according to a new study published December 14 in PLoS Computational Biology.

The failure of normal cell differentiation patterns may explain cancer and senescent decline with aging, say researchers at the University of Arizona, the Santa Fe Institute, the University of Pennsylvania, and the Wistar Institute.

Darwinian natural selection and evolution is usually studied in populations of organisms, but it also applies to cellular populations; this is called somatic evolution. Such somatic evolution tends to reduce cooperation among cells, thus threatening the integrity of the organism.

In this study the authors proposed that a well-known pattern of ongoing cell differentiation in the mature tissues of animals functions to suppress somatic evolution, which is essential to the origin and sustainability of multicellular organisms.

The team, lead by Dr. John Pepper, tested this hypothesis using a computer simulation of cell population dynamics and evolution. The results were consistent with the hypothesis, suggesting that familiar patterns of ongoing cell differentiation were crucial to the evolution of multicellular animals, and remain crucial as a bodily defense against cancer.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers discover important tool in understanding differentiation in human embryonic stem cells
2. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
3. Interaction of just 2 genes governs coloration patterns in mice
4. Spatial patterns in tropical forests can help to understand their high biodiversity
5. New study uncovers secrets behind butterfly wing patterns
6. Can interacting pathogens explain disease patterns?
7. Bits of junk RNA aid master tumor-suppressor gene
8. Evolution is driven by gene regulation
9. Clones on task serve greater good, evolutionary study shows
10. Adaptation to parasites drive African fishes along different evolutionary paths
11. Uncertainty drives the evolution of cooperative breeding in birds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... way the immune system may fight cancers and viral ... cells to treat illness. , The research, in mice, ... "neighborhood police" specialized squads of defenders that patrol ... entire city, the body. , Scientists at Washington University ... the liver, skin and uterus each has dedicated immune ...
(Date:4/17/2014)... of our ideas about domestication derive from Charles ... by British animal-breeding practices during the 19th century, ... improvement. , It is from Darwin that ... of captive animals from wild species and total ... But animal management in this industrial setting has ...
(Date:4/16/2014)... Florida State University researchers have identified a new ... bone density and muscle mass with obesity. , "It ... were the better your bones would be because the ... Hazel Stiebeling Professor of Nutrition at Florida State. "But, ...
Breaking Biology News(10 mins):Some immune cells defend only 1 organ 2The story of animal domestication retold 2The story of animal domestication retold 3The story of animal domestication retold 4Researchers: Obesity can amplify bone and muscle loss 2
... A new study from Boston University School of Medicine ... (iPS) cells in an experimental model were not rejected ... published online in Cell Stem Cell , demonstrates ... types that could offer treatment for a wide range ...
... Research Institute (TSRI) have been awarded approximately $1.2 million ... the National Institutes of Health to identify, test and ... of diseases, including rheumatoid arthritis, heart disease and several ... director in TSRI,s Translational Research Institute, and Peter S. ...
... German . , The detector combines near-unity ... very low error rate. The results have been published ... and reliable single-photon detectors are among the most sought-after ... yet reached maturity for practical application. Physicist Dr. Wolfram ...
Cached Biology News:BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection 2Grant to fund development of drug candidates for rheumatoid arthritis, neurodegenerative disorders 2Quantum communication: Each photon counts 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 Look inside ... hard-working items for the lab, from fluid handling to ... (GIS)—ready to ship when you order. , Preferred ... Pumps , from the L/S® model for precise flow ...
(Date:1/15/2014)... 2014 A study has been launched to ... 1 track could help to tackle the problem of obesity. ... (a GP surgery based in Stowmarket) and academics at University ... Telemetry technology, which is inspired by equipment used to ...
(Date:1/15/2014)... 2013 was a banner year of continued ... saw continued independent research led by the team at ... $1 million grant from the Susanne Marcus Collins Foundation, ... peer reviewed journal, Amy Grant highlighted Brainwave Optimization® in ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... fruit fly and roundworm,s functional genomic elements: DNA sequences in ... are turned on and off at various times in different ... Human Genome Project, the genomes of the fruit fly, ... are powerful models for understanding human biology and disease, ...
... 22, 2010 Pathfinder LLC, a private biotechnology company ... cell damage ("Pathfinder"), and SyntheMed, Inc. (OTC Bulletin Board: ... the "Company"), today announced that they have entered into ... renamed  "Pathfinder Cell Therapy, Inc." and the combined company ...
... Inc. (Nasdaq: NVAX ) and scientists at ... Trudy Morrison, published in the January 2011 issue of ... novel virus-like particle (VLP) vaccine candidate against respiratory syncytial ...  This vaccine candidate has been created with technology that ...
Cached Biology Technology:Scientists reveal how biological activity is regulated in fruit fly and roundworm genomes 2Scientists reveal how biological activity is regulated in fruit fly and roundworm genomes 3Scientists reveal how biological activity is regulated in fruit fly and roundworm genomes 4Pathfinder LLC and SyntheMed, Inc. Announce Merger Agreement 2Pathfinder LLC and SyntheMed, Inc. Announce Merger Agreement 3Pathfinder LLC and SyntheMed, Inc. Announce Merger Agreement 4Pathfinder LLC and SyntheMed, Inc. Announce Merger Agreement 5Pathfinder LLC and SyntheMed, Inc. Announce Merger Agreement 6NOVAVAX and University of Massachusetts Medical School Publish Preclinical Safety and Efficacy Study of a Respiratory Syncytial Virus (RSV) Virus-like Particle (VLP) Vaccine Candidate 2NOVAVAX and University of Massachusetts Medical School Publish Preclinical Safety and Efficacy Study of a Respiratory Syncytial Virus (RSV) Virus-like Particle (VLP) Vaccine Candidate 3NOVAVAX and University of Massachusetts Medical School Publish Preclinical Safety and Efficacy Study of a Respiratory Syncytial Virus (RSV) Virus-like Particle (VLP) Vaccine Candidate 4