Navigation Links
Bodily breakdown explained: How cell differentiation patterns suppress somatic evolution
Date:12/13/2007

Natural selection can occur at the cellular level, where it is detrimental to health. Fortunately it is normally controlled by a well-known pattern of ongoing cell differentiation in the mature tissues of animals, according to a new study published December 14 in PLoS Computational Biology.

The failure of normal cell differentiation patterns may explain cancer and senescent decline with aging, say researchers at the University of Arizona, the Santa Fe Institute, the University of Pennsylvania, and the Wistar Institute.

Darwinian natural selection and evolution is usually studied in populations of organisms, but it also applies to cellular populations; this is called somatic evolution. Such somatic evolution tends to reduce cooperation among cells, thus threatening the integrity of the organism.

In this study the authors proposed that a well-known pattern of ongoing cell differentiation in the mature tissues of animals functions to suppress somatic evolution, which is essential to the origin and sustainability of multicellular organisms.

The team, lead by Dr. John Pepper, tested this hypothesis using a computer simulation of cell population dynamics and evolution. The results were consistent with the hypothesis, suggesting that familiar patterns of ongoing cell differentiation were crucial to the evolution of multicellular animals, and remain crucial as a bodily defense against cancer.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3460
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers discover important tool in understanding differentiation in human embryonic stem cells
2. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
3. Interaction of just 2 genes governs coloration patterns in mice
4. Spatial patterns in tropical forests can help to understand their high biodiversity
5. New study uncovers secrets behind butterfly wing patterns
6. Can interacting pathogens explain disease patterns?
7. Bits of junk RNA aid master tumor-suppressor gene
8. Evolution is driven by gene regulation
9. Clones on task serve greater good, evolutionary study shows
10. Adaptation to parasites drive African fishes along different evolutionary paths
11. Uncertainty drives the evolution of cooperative breeding in birds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... , May 19, 2015  Technology is rapidly advancing, ... and in the cloud. Passwords and their management are ... OTP and standards-based specifications such as those developed by ... use of passwords presents for BYOD, COPE, IoT, and ... biometric identity protocol. In response to ...
(Date:5/14/2015)... , May 14, 2015  Verificient ... identity verification and online remote proctoring, announced ... software-as-a-service (SaaS) company and creator of the ... of the two companies will benefit from ... Canvas. As a fully integrated ...
(Date:5/10/2015)... Fingerprint Cards (FPC) has received an ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... manufacturers in China . The order value ... of + 1 000 MSEK for 2015.   Jörgen ...
Breaking Biology News(10 mins):HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... press release is available in German . , ... time, show changes in their mechanical properties. The exact course ... the microscopic structure and the complexity of the systems make ... led by Professor Andreas Bausch from the Chair of Cellular ...
... scientists have solved a perplexing mystery regarding one of ... shedding light on a possible route to treatment of ... disease occurs when a genetic mutation causes excessive amounts ... a chain-like molecule the body uses to temporarily store ...
... from a devastating condition known as critical limb ischemia ... amputation. The disease is linked to the blockage ... treatment options include rehabilitative exercise and surgical bypass of ... be a way to restore blood supply in skeletal ...
Cached Biology News:Discovery of source of glycogen 'manufacturing' errors sheds light on fatal disease 2Scientists discover genetic switch that increases muscle blood supply 2Scientists discover genetic switch that increases muscle blood supply 3
(Date:5/27/2015)... NJ (PRWEB) May 27, 2015 The ... evaluating the impact of regulation on medical innovation, has ... Innovation (iPCI) of Fairleigh Dickinson University’s ( FDU ... MI3 Alert pertains to new FDA (Food ... proposal for accelerating the approval of certain medical devices. ...
(Date:5/26/2015)... GERMANY (PRWEB) May 26, 2015 ... R. Grace & Co. (NYSE: GRA) announces that ... good manufacturing practice (GMP) certification from EXCiPACT™, an ... of pharmaceutical excipients. , All three ... of pharmaceutical grade excipient silica gels have now ...
(Date:5/26/2015)... May 26, 2015  Sangamo BioSciences, Inc. (NASDAQ: SGMO ... and CEO, will provide an update on the progress of ... of the company,s business strategy at 1:30pm ET on Monday, ... The conference is being held in New York, ... live and may be accessed via a link on the ...
(Date:5/26/2015)... Global Stem Cells Group and ... company’s first cellular and regenerative medicine symposium in Barcelona ... hands-on stem cell training class Oct. 10. The event ... President of Therapeutic Confrontations (CONFTERA) in Barcelona. , ... regenerative medicine and recent advances in cellular therapies, Global ...
Breaking Biology Technology:Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Sangamo BioSciences Announces Presentation At The Jefferies 2015 Global Healthcare Conference 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 3
... Agreement on Molecular Tests... -- GERMANTOWN, Maryland and DES PLAINES, Illinois, October 12, 2010, ... ... --> ... s = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
... Calif., Oct. 12 WaferGen Biosystems, Inc. (OTC Bulletin ... state-of-the-art genomic analysis systems, today announced that Gary P. ... next generation sequencing for gene expression at Illumina, Inc., ... Research and Applications, a new position created to build ...
... With more than 200 researchers in attendance at ... two technologies that facilitate data-driven research: the Microsoft ... (Logo: http://photos.prnewswire.com/prnh/20000822/MSFTLOGO ) ... developers in bioscience now have access to the ...
Cached Biology Technology:QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 2QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 3QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 4QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 5QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 6QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 7QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 8QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 9QIAGEN and Abbott Enter Into Agreement on Molecular Tests for HIV, HCV and HPV 10WaferGen Names Gary P. Schroth, Ph.D., as New SVP, Genomics Research and Applications 2WaferGen Names Gary P. Schroth, Ph.D., as New SVP, Genomics Research and Applications 3WaferGen Names Gary P. Schroth, Ph.D., as New SVP, Genomics Research and Applications 4WaferGen Names Gary P. Schroth, Ph.D., as New SVP, Genomics Research and Applications 5Microsoft Research Makes Microsoft Biology Foundation and MODISAzure-Based Environmental Service Available to Scientists and Researchers 2Microsoft Research Makes Microsoft Biology Foundation and MODISAzure-Based Environmental Service Available to Scientists and Researchers 3Microsoft Research Makes Microsoft Biology Foundation and MODISAzure-Based Environmental Service Available to Scientists and Researchers 4
...
IMAGEQUANT 300 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Recombinant Feline IL-12/IL-23 p40...
Biology Products: