Navigation Links
Blueprint for next generation of chronic myeloid leukemia treatment
Date:8/20/2014

oal is to have a TKI option for every patient."

"We were able to sequence about 100 clinical samples, which gave us a very large body of data to shed light on the number of compound mutations and how they develop," said Michael Deininger, MD, PhD, co-senior author of the study, a professor of Internal Medicine, and an HCI investigator. "One key finding was that compound mutations containing an already known mutation called T315I tend to confer complete resistance to all available TKIs."

Working with HCI computational chemist Nadeem Vellore, PhD, the research team modeled at the molecular level why the drugs do not bind to certain BCR-ABL compound mutants. "This puts us in position to evaluate new drug candidates and work toward developing new treatments," said O'Hare.

"Computational analysis was one of the most interesting parts of the study. It not only confirmed what we found but showed the reason behind it," said Matthew Zabriskie, BS, co-lead author of the study. "We've established what the next level of TKI resistance is going to entail."

According to O'Hare, it is only a matter of time until analogous compound mutations emerge in many other cancers, including non-small cell lung cancer (NSCLC) and acute myeloid leukemia (AML). In these diseases, scientists and clinicians are still learning how to control single mutation-based resistance. "Our findings in CML will provide a blueprint for contending with resistance in these highly aggressive diseases as well," he said.


'/>"/>
Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Genetic blueprint of bread wheat genome unveiled
2. Conservationists to create blueprint for saving Malaysias elephants
3. Salk scientists redraw the blueprint of the bodys biological clock
4. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
5. Adipose-derived stem cells and nerve regeneration
6. Understanding parallels of human and animal parenting can benefit generations to come
7. Microtubule-based strategies for promoting nerve regeneration after injury
8. Smart Technology Consumers Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet
9. NXT-IDs Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st
10. Researcher using next-generation sequencing to rapidly identify pathogens
11. NRG1 isoforms could be an effective therapeutic candidate to promote peripheral nerve regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blueprint for next generation of chronic myeloid leukemia treatment
(Date:9/30/2014)... salmon, and strawberries all have in common? Unlike ... chromosomes and are diploid, these organisms are all polyploid, ... watermelon and salmon have 3 and 4 sets of ... might seem surprising, in fact most plant species are ... a century ago, but only recently, with the development ...
(Date:9/30/2014)... water may increase the risk of stillbirth and ... by a Boston University School of Public Health ... Environmental Health , compared 1,091 PCE-exposed pregnancies ... Cape Cod, Ma., where water was contaminated in ... the installation of vinyl-lined asbestos cement pipes. PCE ...
(Date:9/30/2014)... involving mice and published in the October 2014 issue ... , suggests that just because you can do it, ... of Italian scientists have found that using marijuana in ... system. This damage may result in autoimmune diseases and ... disease and rheumatoid arthritis in adulthood. , "I hope ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Contaminated water linked to pregnancy complications, BU study finds 2Adolescent exposure to thc may cause immune systems to go up in smoke 2
... threatened with extinction around the globe, efforts to save ... conservation: a chance for complete recovery, according to health ... other members of the Blue Iguana Recovery Program. ... the Blue Iguana Recovery Programa consortium of local and ...
... French . Some of the human X ... outside Africa, according to an international team of researchers led ... University of Montreal and the CHU Sainte-Justine Research Center. The ... Biology and Evolution. "This confirms recent findings ...
... men and women in England and over a third of ... diabetes and heart disease and can significantly shorten a person,s ... journal International Journal of Behavioral Nutrition and Physical Activity ... of weight loss programs based on diet and exercise. ...
Cached Biology News:Grand Cayman blue iguana: Back from the brink of extinction 2Genetic research confirms that non-Africans are part Neanderthal 2'Love your body' to lose weight 2
(Date:9/30/2014)... 2014 Whitehouse Laboratories is ... the Parenteral Drug Association (PDA) to host ... on container closure integrity testing. This lecture/laboratory course will ... and philosophies detailed in the recently proposed revision to ... The course will span container closure integrity testing (leak ...
(Date:9/29/2014)... 30, 2014 Each year in ... require medical attention. In the military, burn injury ... to battlefield medical care. More than 800 service ... Burn wounds heal slowly, remain inflamed and often ... physically debilitating and functionally damaging. While developments in ...
(Date:9/29/2014)... , Sept. 29, 2014  Ten of the ... of cartilage repair, regeneration, allograft reconstruction and research ... the world gathered to discuss the future of ... of Regenerative Medicine symposium, Cartilage Regeneration: State ... included Orthopedic Biosurgery, Minced Juvenile Allograft, and State ...
(Date:9/29/2014)... emerging diseases and biodiversity loss requires evolutionary thinking, ... Science Express that was co-authored by Bruce ... Agriculture and Life Sciences. , For the first ... reviewed progress in addressing a broad set of ... approaches that consider evolutionary histories and the likelihood ...
Breaking Biology Technology:Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4Faster Healing with Fewer Scars 2World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3Evolutionary biology: It's not just for textbooks anymore 2Evolutionary biology: It's not just for textbooks anymore 3
... 21, 2010 -- Scientists from the Hebrew University of ... to greatly expand the memory capacity of future computers ... nanoparticles combined with protein molecules obtained from the poplar ... have developed an alternative avenue to miniaturize memory elements ...
... , July 21 Responding to a lack of voter ... bio-medical pioneer and mega-entrepreneur, today announced his intention to conduct a write-in ... , ... of Bioheart Inc., a biotechnology company, and owner of Leonhardt Vineyards ( ...
... ViroPharma Incorporated,s (Nasdaq: VPHM ) second quarter financial results for 2010 are ... of the U.S. financial markets. , , ... host a conference call and live audio webcast at 9:00 a.m. Eastern Time ... 2010 second quarter financial results and other business. , ...
Cached Biology Technology:Protein from poplar trees can be used to greatly increase computer capacity 2Howard J. Leonhardt Announces Candidacy for Governor of California 2Howard J. Leonhardt Announces Candidacy for Governor of California 3Howard J. Leonhardt Announces Candidacy for Governor of California 4ViroPharma to Release 2010 Second Quarter Financial Results on July 28, 2010 2
Recombinant Feline IFN-alpha...
Anti-OSMR Monoclonal Antibody Research Focus: cytokine/growth factor Storage: 4C Shipping Temperature: 4C...
Rabbit polyclonal to Presenilin 1, prediluted ( Abpromise for all tested applications). entrezGeneID: 5663 SwissProtID: P49768...
ROCK-1 (cleaved) Monoclonal Ab 100 ug purified mouse monoclonal antibody. Clone# 12M03. Reacts with human. Tested in Western blot analysis....
Biology Products: