Navigation Links
Blue light used to harden tooth fillings stunts tumor growth
Date:6/24/2008

A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say.

"The light sends wavelengths of blue-violet light to the composite, which triggers hardening," says Alpesh Patel, a rising MCG School of Dentistry junior. "The light waves produce free radicals that activate the catalyst and speed up polymerization of the composite resin. In oral cancer cells, though, those radicals cause damage that decreases cell growth and increases cell death."

Mr. Patel, who has been working with Dr. Jill Lewis, associate professor of oral biology, Dr. Regina Messer, associate professor of oral rehabilitation and oral biology, and Dr. John Wataha, adjunct professor of oral rehabilitation and oral biology, studied 10 tumor-bearing mice, five treated with the light and five untreated.

He exposed half the mice to the blue light for 90 seconds a day for 12 days. Then the tumors were extracted and each one was split into two sections. Half were used to create slides for tissue analysis, and half were frozen to prepare protein extracts.

Tissue analysis indicated an approximate 10 percent increase in cell suicide, or apoptosis, in the light-treated tumors. The frozen protein extracts revealed a nearly 80 percent decrease in cell growth in the light-treated tumors.

"The decrease in cell growth, combined with increased apoptosis, helps explain why the tumors didn't grow as much because you have cells that aren't dividing and you have cells that are committing suicide," Mr. Patel says.

Dr. Lewis predicts treating the tumors with blue light sooner will increase the rate of apoptosis, possibly preventing the tumor from ever becoming measurable and easing treatment.

"One desirable feature we've observed with the blue light is that non-cancerous cells appear unaffected at light doses that kill tumor cells," says Dr. Lewis. "We're thinking that some day, blue light therapy may serve as an adjunct to conventional cancer therapy. Patients may, therefore, receive lower doses of chemotherapy, which would decrease the adverse effects most cancer patients experience from standard chemotherapy regimens."


'/>"/>

Contact: Amy Connell
aconnell@mcg.edu
706-721-8605
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. July 2008 GEOLOGY and GSA Today media highlights
2. July 2008 highlights
3. Genome sequence of small marine creature sheds light on vertebrate origins
4. Highlights from the June 2008 Journal of the American Dietetic Association
5. New text highlights role of microorganisms in alternative energy development
6. June GEOSPHERE media highlights
7. Undergraduates develop dirt-powered microbial fuel cells to light Africa
8. UV lotion lights the way to cleaner facilities
9. Highlights from the May 2008 Journal of the American Dietetic Association
10. European light research opens door for optical storage and computing
11. Detecting dangerous chemicals with lasers, exploring the brains circuitry with light and more
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blue light used to harden tooth fillings stunts tumor growth
(Date:4/13/2017)... PUNE, India , April 13, 2017 According ... Identity Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication ... by MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 ... Annual Growth Rate (CAGR) of 17.3%. ... ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
Breaking Biology News(10 mins):
(Date:8/22/2017)... MA (PRWEB) , ... August 22, 2017 , ... ... new service pipeline built upon patented KBioBox technology, the extended GUIDE-Seq ananlysis. KBioBox ... source GUIDE-Seq computation pipeline to be provide scientists with easy to understand reports, ...
(Date:8/21/2017)... ... 2017 , ... Baltimore biotech firm, PathSensors, Inc., announced today ... proprietary CANARY pathogen detection technology and high throughput testing solutions to the Chinese ... undisclosed number of PathSensors’ Zephyr pathogen detection instruments and will act as a ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... announce that they will feature Federal Hybrids, Inc. in an upcoming episode, scheduled ... , American Farmer will explore Federal Hybrids, the independent, family-owned seed company. ...
(Date:8/16/2017)... ... August 16, 2017 , ... Tunnell Consulting announced today that four ... ISPE Annual Meeting and Expo , to be held October 29 through November 1 ... “Driving innovation to advance patient therapies.” , The ISPE Annual Meeting and Expo will ...
Breaking Biology Technology: