Navigation Links
Bloodless worm sheds light on human blood, iron deficiency
Date:4/16/2008

and mice.

So Hamza did the non-intuitive thing. He chose a test subject that doesnt make heme, but needs it to survive, that doesnt even have blood, but shares a number of genes with humans the C. elegans roundworm, a simple nematode.

We tried to understand how blood is formed in an animal that doesnt have blood, that doesnt turn red, but has globin, Hamza said.

C. elegans gets heme by eating bacteria in the soil where it lives. C. elegans consumes heme and transports it into the intestine. So now you have a master valve to control how much heme the animal sees and digests via its food, Hamza explains.

C. elegans has several other benefits for studying heme transport. Hamzas team could control the amount of heme the worms were eating. With only one valve controlling the heme transport, the scientists knew exactly where heme was entering the worms intestine, where, as in humans, it is absorbed.

And C. elegans is transparent, so that under the microscope researchers could see the movement of the heme ingested by the worm.

Genes and Iron Deficiency

The study revealed several findings that could lead to new treatment for iron deficiency. One was the discovery that genes are involved in heme transport. Hamzas group found that HRG-1 genes, which are common to humans and C. elegans, were important regulators of heme transport in the worm.

To test their findings in an animal that makes blood, Hamzas team removed the HRG-1 gene in zebrafish. The fish developed bone and brain defects, much like birth defects. The gene removal also resulted in a severe form of anemia usually caused by iron deficiencies.

When they substituted the zebrafish gene with the worm HRG-1 gene, the mutant fish returned to normal, indicating that the fish and worm genes are interchangeable, irrespective of the animals ability to make blood.

They also found that too little or too much heme can kill C. elegans, a result that could help resear
'/>"/>

Contact: Ellen Ternes
eternes@umd.edu
301-405-4627
University of Maryland
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Journey to the center of the earth: Discovery sheds light on mantle formation
2. New radar satellite technique sheds light on ocean current dynamics
3. 480-million-year-old fossil sheds light on 150-year-old paleontological mystery
4. Research sheds light on the mechanics of gene transcription
5. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
6. Massive dinosaur discovered in Antarctica sheds light on life, distribution of sauropodomorphs
7. Research sheds new light on how diseases jump across species
8. New study sheds light on Galápagos hawk evolutionary history
9. CU-Boulder worm study sheds light on human aging, inherited diseases
10. UT researcher sheds new light on hybrid animals
11. New research sheds light on Hobbit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... , July 29, 2014 Research and ... SaaS-based Business Intelligence (BI) Market 2014-2018" report to ... The term BI refers to applications ... to, or analyzing information about a company,s operations. BI ... affecting their business; for example, metrics on sales, production, ...
(Date:7/29/2014)... But on the remote UK overseas territory of Ascension ... is undergoing something of a renaissance. , Writing in ... the University of Exeter and Ascension Island Government Conservation ... at the remote South Atlantic outpost has increased by ... the 1970s. As many as 24,000 nests are now ...
(Date:7/29/2014)... University of Maryland Schools of Dentistry (UM SOD) ... they have received a five-year $10.7 million grant ... Infectious Diseases (NIAID) of the National Institutes of ... of sexually-transmitted diseases (STDs). The grant, which renews ... represents a new direction for the research by ...
Breaking Biology News(10 mins):Global SaaS-based Business Intelligence (BI) Market 2014-2018 2Major turtle nesting beaches protected in 1 of the UK's far flung overseas territories 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4
... Researchers at Rensselaer Polytechnic Institute have secured ... virtual reality simulator for next-generation "scarless" endoscopic surgery. ... National Institutes of Health (NIH), seeks to accelerate ... or NOTES. This emerging surgical technique shows promise ...
... those battery-pack organelles that fuel the energy of almost ... Whether in a dish or a living organism, the ... Because calcium levels link to many essential biological processesnot ... have been working for half a century to identify ...
... Scientists and educators alike have long known that cramming ... their latest findings, researchers at the RIKEN Brain Science ... mice, have elucidated the neurological mechanism explaining why this ... , their results suggest that protein synthesis in the ...
Cached Biology News:Rensselaer researchers secure $2.7 million NIH grant to advance 'scarless' surgery 2Rensselaer researchers secure $2.7 million NIH grant to advance 'scarless' surgery 350-year search for calcium channel ends 250-year search for calcium channel ends 3A better way to remember 2
(Date:7/29/2014)... generation biofuels are a viable solution to the dilemma of ... is very cheap, this is affecting the biofuels market in ... could be in comparison to natural gas. This, in ... for renewable energy developers to get the economics to work ... certain companies have shifted their focused within renewable energy. ...
(Date:7/29/2014)... , July 29, 2014 ... Scanners (Whole Slide Imaging), Analytics (Image Analysis Software), Delivery ... - Global Forecasts & Trends to 2018", published by ... restraints in geographies such as North America ... Asia , and the Rest of the World ...
(Date:7/29/2014)... WARRINGTON, Pa. , July 29, 2014 /PRNewswire/ ... company dedicated to advancing a new standard of ... financial results on August 5, 2014 before the ... The Company will host a live teleconference ... day. During the conference call, Discovery Labs, management ...
(Date:7/29/2014)... 29, 2014 /PRNewswire-iReach/ -- Nanosyn, Inc. announced today ... Inc., to provide access to Nanosyn,s microfluidics screening ... platform for novel small molecule therapeutics. ... to work with FORMA Therapeutics to explore key ... homeostasis. FORMA Therapeutics, decision to work with us ...
Breaking Biology Technology:Renewable Waste Intelligence: Could Renewable Chemicals Be the Future for the Renewable Energy Industry? 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3Discovery Labs to Report 2014 Second Quarter Financial Results and Hold Conference Call on Tuesday, August 5, 2014 at 9:00 a.m. Eastern Time 2Nanosyn Announces Expanded Partnership With FORMA Therapeutics 2
... Inc.,(Nasdaq: NGSX ), a biopharmaceutical company focused ... today that,Anthony DiTonno, President and Chief Executive Officer, ... 10th Annual Healthcare Conference in New,York City on ... Ghiglieri,Chief Financial Officer, will also be available to ...
... Company Registered in Switzerland, Will Move its Headquarter ... Various Issues Related to Neovascularisation, - Gene Signal is Working ... Now in Phase III Trials, - Gene Signal Will Present ... the American Academy of Ophtalmologist in Atlanta, USA, the ...
... Idenix,Pharmaceuticals, Inc. (Nasdaq: IDIX ) announced today ... Confab on Tuesday, November,11th at 9:40 a.m. ET., ... be accessed under,"Calendar of Events" in the Idenix Investor ... minutes before the,event to ensure a timely connection. The ...
Cached Biology Technology:NeurogesX to Present at Rodman & Renshaw 10th Annual Healthcare Conference 2NeurogesX to Present at Rodman & Renshaw 10th Annual Healthcare Conference 3Gene Signal Enters Phase III Clinical Tests for the Prevention of Corneal Graft Rejection 2Gene Signal Enters Phase III Clinical Tests for the Prevention of Corneal Graft Rejection 3
... Chain MAP1A and MAP1B are microtubule-associated proteins ... components of the cytoskeleton. MAP1A and MAP1B each ... light chain subunits. The protein encoded by this ... and can associate with either MAP1A or MAP1B. ...
PC based system for advanced chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Conveniently document gels, films and membranes with a high quality thermal printer. , Compact, footprint printer , Supplies 256 gray scale for high resolution, archive-quality thermal film prints...
Conveniently document gels, films and membranes with a high quality thermal printer. , Compact, footprint printer , Supplies 256 gray scale for high resolution, archive-quality thermal film prints...
Biology Products: