Navigation Links
Bloodless worm sheds light on human blood, iron deficiency
Date:4/16/2008

Using a lowly bloodless worm, University of Maryland researchers have discovered an important clue to how iron carried in human blood is absorbed and transported into the body. The finding could lead to developing new ways to reduce iron deficiency, the worlds number one nutritional disorder.

With C. elegans, a common microscopic worm that lives in dirt, Iqbal Hamza, assistant professor of animal and avian sciences, and his team identified previously unknown proteins that are key to transporting heme, the molecule that creates hemoglobin in blood and carries iron. It is a critical step in understanding how our bodies process iron. Their findings are published in the April 16 issue of Nature online.

The structure of hemoglobin has been crystallized over and over, says Hamza, but no one knows how the heme gets into the globin, or how humans absorb iron, which is mostly in the form of heme.

To understand the underlying issues of nutritional and genetic causes of iron deficiency, we are looking at the molecules and mechanisms involved in heme absorption. Once you understand transport of heme, you can more effectively deliver it to better absorb iron in the human intestine.

Heme and Blood

Heme is a critical molecule for health in all eukaryotes, organisms whose cells are organized into complex structures enclosed in membranes. Species of eukaryotes range from humans to bakers yeast. Heme makes blood red and binds to oxygen and other gases we need to survive.

Heme is created in the mitochondria, then moves through pathways that connect other cells, where it is synthesized to form blood. Heme on its own, however, is toxic.

We wanted to find out how heme gets carried between and within cells, said Hamza.

A Bloodless Worm

Eight steps are required to generate heme, making it a difficult process to control in the study of heme transport pathways, as Hamza learned when he first studied the question in bacteria
'/>"/>

Contact: Ellen Ternes
eternes@umd.edu
301-405-4627
University of Maryland
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Journey to the center of the earth: Discovery sheds light on mantle formation
2. New radar satellite technique sheds light on ocean current dynamics
3. 480-million-year-old fossil sheds light on 150-year-old paleontological mystery
4. Research sheds light on the mechanics of gene transcription
5. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
6. Massive dinosaur discovered in Antarctica sheds light on life, distribution of sauropodomorphs
7. Research sheds new light on how diseases jump across species
8. New study sheds light on Galápagos hawk evolutionary history
9. CU-Boulder worm study sheds light on human aging, inherited diseases
10. UT researcher sheds new light on hybrid animals
11. New research sheds light on Hobbit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/188684 for BEHAVIORAL-DIRECTED ... another new convenient and secure method to make ... innovative payment methods, introduced with its groundbreaking voice-direct ...
(Date:7/8/2015)... 2015 Summary Pancreatic cancer is the ... fatal, with a mortality rate of 10.9 deaths per ... cancer patients has highlighted a significant need for new ... met by the current market. A highly active ... varying molecule types and mechanisms of action, which provides ...
(Date:7/7/2015)... VIEW, Calif. , July 7, 2015 /PRNewswire/ ... biometrics market, Frost & Sullivan recognizes Credence ID, ... Sullivan Entrepreneurial Company of the Year Award. ... suite to aid in its mission of offering ... under-recognized populations globally. As Credence ID was formed ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5
... 2009 issue of the Journal of General Physiology ... University of British Columbia, Vancouver) and colleagues that explores ... using in vivo nonsense suppression technology. The study will ... According to Riccardo Olcese (UCLA) in a commentary accompanying ...
... DURHAM, N.H. Two University of New Hampshire ... (NSF) Faculty Early Career Development (CAREER) grants. Vaughn ... biomedical sciences received $1 million to better understand ... students in data collection. Christopher White of the ...
... Mountain goats are no exception to the general ... healthier offspring. But University of Alberta researcher David Coltman ... mountain goats think twice about their romantic partners. ... taking the eligible females for themselves. The larger males ...
Cached Biology News:2 UNH faculty receive $1.4M in CAREER grants from NSF 2
(Date:7/30/2015)... ... July 30, 2015 , ... Leading regenerative veterinary medicine company, ... canine osteoarthritis stem cell product, currently under development for FDA approval. The product ... marketed in the US by Aratana. This product, termed AT-016, is an allogeneic ...
(Date:7/30/2015)... 30, 2015 Ascendis Pharma A/S (Nasdaq: ... its innovative TransCon technology to address significant unmet ... a six-month Phase 2 study to evaluate the ... in 53 treatment-naïve, pre-pubertal children with growth hormone ... pleased with the top-line results from our Phase ...
(Date:7/30/2015)... ... July 30, 2015 , ... GEA's Pony™ NS2006L ... operation up to 1500 bar. The sanitary design gauge of the NS2006L is ... , The Pony™ NS2006L homogenizer is an ideal solution for the processing of ...
(Date:7/29/2015)... US-Australian drug discovery company, Novogen Limited (ASX: ... committed to progressing its ground-breaking technology platforms to Phase ... ensure the Company delivers the best value for shareholders. ... , said the Company currently had an extensive program ... programs and academic partnerships and initiatives, and he was ...
Breaking Biology Technology:VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10
... Reagents to ... Advance Cancer Research, NEWARK, ... ) -- a leader in providing advanced antibody,products and services ... by Science Applications International Corporation - Frederick,(SAIC-F), to develop monoclonal ...
... 7 at 1:45 PM, DALLAS, April 3, 2008 ... digital health research at ATA 2008 at the,Washington State ... Harry will highlight findings from Private Insurance and ... insurance industry featuring,interviews with twenty senior executives from the ...
... Ratcliff, the,award-winning architecture, planning and interiors firm, master ... tower,accompanied by a 767-stall parking garage and 20,000-square-foot ... Walnut Creek Campus. The Thomas J.,and Muriel T. ... will add,230 private and six semi-private rooms, increasing ...
Cached Biology Technology:Strategic Diagnostics Inc. Selected as Key Supplier to SAIC-F and the National Cancer Institute for the Development of a Comprehensive Portfolio of Antibodies for Use in Cancer Research 2Strategic Diagnostics Inc. Selected as Key Supplier to SAIC-F and the National Cancer Institute for the Development of a Comprehensive Portfolio of Antibodies for Use in Cancer Research 3Parks Associates' Digital Health Analyst to Present Latest Research and Forecasts at ATA Show 2Ratcliff Designs Hospital of the Future for John Muir Medical Center - Walnut Creek Campus 2Ratcliff Designs Hospital of the Future for John Muir Medical Center - Walnut Creek Campus 3
Standard 2" or 3" Plastic can be ordered with 81 or 100 cell dividers. Mini 2" Plastics Boxes come standard with 25 cell dividers. Plastic boxes can also be ordered with corresponding freezer racks...
Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of be...
Request Info...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to KLH (Keyhole Limpet Hemocyanin) lysine through amide bonds....
Biology Products: