Navigation Links
Blood vessel builders
Date:10/13/2009

CLEVELAND Futuristic plans to grow replacement organs, bones or muscles for soldiers maimed on the battlefield or patients suffering from debilitating disease or injury won't be anything but science fiction unless new blood vessels can grow into that tissue.

Without blood vessels delivering oxygen and nutrients and clearing out waste, any replacement parts would starve.

Holding out stimulus money as an incentive, the National Institutes of Health challenged investigators across the country to come up with formulas to build vascular networks in engineered tissues.

A team of Case Western Reserve University researchers was awarded a $1 million "Challenge Grant" for their proposal to combine custom-designed synthetic molecules with the best-suited stem cells for the job. Leading the project are Roger Marchant and Horst von Recum, professors of biomedical engineering at the Case School of Engineering.

The researchers are developing their approach in a mouse, as a model for technology that could be used to improve human lives. The goal is to produce vascular networks that grow and maintain themselves like those that grow naturally.

"We're bringing together unique skills that alone wouldn't address the problem," said Marchant, who's had a long, distinguished career in biomimicry, imitating designs and processes found in nature.

Marchant has built complex synthetic molecules that assemble on vascular grafts and lay a foundation for a coating of sugar-rich molecules that prevent blood clots. He's developed synthetic proteins that latch onto bacteria and can prevent colonization on surfaces or act as a direct drug delivery site.

Over the next two years, Marchant will try to build molecules that assemble into the scaffolding of an entire network of blood vessels and attach stem cells onto the surface. "We're no longer working in two dimensions," he said. "We have to come up with techniques to build in three dimensions."

The project requires embryonic stem cells because adult vascular cells fail to regenerate quickly enough to build blood vessels, von Recum explained.

Recently, von Recum helped discover a way to identify which stem cells will successfully differentiate into endothelial cells the cells that line blood vessels and to remove other, unwanted cell types.

Von Recum's group will genetically modify the select stem cells to home in on and attach to Marchant's scaffolding and even break down and remodel the scaffolding as needed.

"In the body, our tissues are constantly regenerating and remodeling," von Recum said. "Osteoporosis is an example of what can go wrong: the cells that break down bone are working faster than cells that rebuild bone.

"A synthetic scaffold can't regenerate and remodel, but we can introduce new DNA in the stem cells so they can remodel the scaffolding, break down pieces of scaffolding in the way."


'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Blood counts are clues to human disease
2. New blood-thinning drug safer than rat poison
3. University of Iowa scientists use blood-brain barrier as therapy delivery system
4. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
5. Diesel exhaust is linked to cancer development via new blood vessel growth
6. New information about how fat increases blood pressure could help identify those at risk
7. Gene signal GS-101 data shows safe and effective inhibition of ophthalmic blood vessel growth
8. Blood-flow metabolism mismatch predicts pancreatic tumor aggressiveness
9. Glow-in-the-dark red blood cells made from human stem cells
10. Anti-aging gene linked to high blood pressure
11. Mothers immune system may block fetal treatments for blood diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... ... July 13, 2017 , ... Dr. Joshua Mondlick has introduced the LANAP® protocol ... Mondlick Perio, in the Phoenix area. Dr. Mondlick is at the forefront ... cleared laser treatment to re-grow bone and with significantly less pain than traditional surgery ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... Thousands of ... and August for the National Aeromodeling Championships (Nats). Pilots come to Muncie to compete ... to earn spots on US teams that participate in world championships. , RC Pylon ...
(Date:7/13/2017)... , ... July 13, 2017 , ... ... two spectrophotometer calibration standards. Blast forward seven years and now they are ... holmium oxide for wavelength accuracy, and resolution testing. , ...
(Date:7/13/2017)... ... July 13, 2017 , ... Trinity Sterile, ... reusable medical supplies has chosen The Copley Consulting Group to implement and deploy ... to align its internal and backend operations to streamline efficiencies to meet the ...
Breaking Biology Technology: