Navigation Links
Blood vessel builders
Date:10/13/2009

CLEVELAND Futuristic plans to grow replacement organs, bones or muscles for soldiers maimed on the battlefield or patients suffering from debilitating disease or injury won't be anything but science fiction unless new blood vessels can grow into that tissue.

Without blood vessels delivering oxygen and nutrients and clearing out waste, any replacement parts would starve.

Holding out stimulus money as an incentive, the National Institutes of Health challenged investigators across the country to come up with formulas to build vascular networks in engineered tissues.

A team of Case Western Reserve University researchers was awarded a $1 million "Challenge Grant" for their proposal to combine custom-designed synthetic molecules with the best-suited stem cells for the job. Leading the project are Roger Marchant and Horst von Recum, professors of biomedical engineering at the Case School of Engineering.

The researchers are developing their approach in a mouse, as a model for technology that could be used to improve human lives. The goal is to produce vascular networks that grow and maintain themselves like those that grow naturally.

"We're bringing together unique skills that alone wouldn't address the problem," said Marchant, who's had a long, distinguished career in biomimicry, imitating designs and processes found in nature.

Marchant has built complex synthetic molecules that assemble on vascular grafts and lay a foundation for a coating of sugar-rich molecules that prevent blood clots. He's developed synthetic proteins that latch onto bacteria and can prevent colonization on surfaces or act as a direct drug delivery site.

Over the next two years, Marchant will try to build molecules that assemble into the scaffolding of an entire network of blood vessels and attach stem cells onto the surface. "We're no longer working in two dimensions," he said. "We have to come up with techniques to build in three
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Blood counts are clues to human disease
2. New blood-thinning drug safer than rat poison
3. University of Iowa scientists use blood-brain barrier as therapy delivery system
4. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
5. Diesel exhaust is linked to cancer development via new blood vessel growth
6. New information about how fat increases blood pressure could help identify those at risk
7. Gene signal GS-101 data shows safe and effective inhibition of ophthalmic blood vessel growth
8. Blood-flow metabolism mismatch predicts pancreatic tumor aggressiveness
9. Glow-in-the-dark red blood cells made from human stem cells
10. Anti-aging gene linked to high blood pressure
11. Mothers immune system may block fetal treatments for blood diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... about complex social behavior by studying nonhuman mammals and ... , With their unusually large brains relative to their ... complex social environment---not merely in a large population of ... a dynamic setting of alliances and competitors. The same ... primates, and social carnivores, like hyenas and lions. , ...
(Date:9/16/2014)... of severe maternal morbidity amongst women in Australia ... new study published today (17 September) in ... . , Australians generally enjoy high standards of ... disparities exist, in particular between indigenous and non ... explore the independent impact of socioeconomic position on ...
(Date:9/16/2014)... neuroscientists have discovered the "molecular brakes" that time the ... of mice. These "hair cells" translate sound waves into ... are interpreted as sounds. If the arrangement of the ... summary of the research will be published in ... "The proteins Hey1 and Hey2 act as brakes to ...
Breaking Biology News(10 mins):Being social: Learning from the behavior of birds 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 3Hey1 and Hey2 ensure inner ear 'hair cells' are made at the right time, in the right place 2
... genome-wide study to demonstrate an inherited genetic basis for ... American ancestry with an increased risk of relapse in ... at St. Jude Children,s Research Hospital and the Children,s ... ancestry as a potential new marker of poor treatment ...
... 5, 2011 With millions of people warding off ... are raising red flags about the potential health effects ... published in the American Chemical Society,s (ACS,) journal, ... particles inhaled into the lungs from wood smoke may ...
... Everyone knows chocolate is critical to a happy Valentine,s Day. Now ... happy the rest of the year. It,s a gene called ... you could be at risk for some types of heart disease. ... of North Carolina at Chapel Hill School of Medicine appear in ...
Cached Biology News:Native American ancestry linked to greater risk of relapse in young leukemia patients 2Native American ancestry linked to greater risk of relapse in young leukemia patients 3Just in time for Valentine's Day: UNC researchers identify a gene critical for heart function 2
(Date:9/17/2014)... Hussey Copper , a leader in ... copper, announces Gilmour Academy Ice Arena,s conversion of more ... solid touch surface to help protect against bacteria.  MD-Cu ... that kills greater than 99.9% of MRSA, E-coli and ... , Innovative Gilmour Academy ...
(Date:9/17/2014)... , 17 de septiembre de 2014 /PRNewswire/ ... principal proveedor mundial de soluciones logísticas avanzadas ... de la vida, anunció hoy la contratación ... global con sede en Rótterdam, Países Bajos, ... clientes Europa en rápido crecimiento. Según los ...
(Date:9/17/2014)... The Pistoia Alliance, a global not ... to innovation in life sciences R&D through pre-competitive ... as Executive Director Business Development North America, as ... , Carmen joins the Pistoia Alliance from Accelrys ... Accelrys, she managed various life sciences and material ...
(Date:9/16/2014)... 2014  Biocom, the association representing the ... 9 th Annual National Health Information Technology Week, ... in improving our health care system. ... the world,s most vibrant hubs for health IT and ... to genomic testing to remote patient monitoring," said ...
Breaking Biology Technology:Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2Biocom Recognizes National Health IT Week 2
... 18 Trust for America,s,Health (TFAH) today released ... Health from Disease, Disasters, and Bioterrorism" report, which,found ... areas of the,nation,s emergency health preparedness effort still ... cuts in federal funding for state,and local preparedness ...
... Ore., Dec. 18 Synthetech, Inc. (OTC,Bulletin ... Performance Improvement,Awards for their outstanding accomplishments in ... Silver Awards are presented by,the Synthetic Organic ... SOCMA,s EHS&S initiative. The awards are highly,regarded ...
... documentation for achieving lab ... now turnkey solution, BUFFALO GROVE, Ill., Dec. ... and academia incorporating laboratory operations,into their enterprise now ... total environmental control, energy efficiency and compliance,from Siemens ...
Cached Biology Technology:Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness 2Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness 3Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness 4Significant Progress Made in Nation's Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness 5Synthetech Earns National Recognition for Performance Improvement Program 2Synthetech Earns National Recognition for Performance Improvement Program 3Siemens Building Technologies Helping Companies Participate in EPA Labs21 Movement With Comprehensive Compliance Solution Strategy 2
IMAGEQUANT 100 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
Request Info...
RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
...
Biology Products: