Navigation Links
Blood test predicts chance of dementia
Date:3/5/2009

Frontal lobe dementia

Frontal lobe dementia (Frontotemporal Dementia, FTD) strikes people at an earlier age. After Alzheimer's disease, FTD is the form of dementia that occurs most frequently in patients younger than 65. In FTD, the disease process starts in the frontal lobe where large numbers of brain cells begin to die off. The frontal lobe is the foremost part of the brain and constitutes about 30% of the brain. Among other things, it is involved in regulating behavior, movement and mood, and it is responsible for cognitive functions such as language. So, the first clinical signs of FTD are changes in behavior and personality, and then, in a later stage of the disease, the loss of memory functions.

Progranulin: a main actor

Genetic research has shown previously that there is a genetic defect in chromosome 17 in a large percentage of the families with FTD. There are two genes in chromosome 17 that, if a defect occurs, cause a hereditable form of FTD. In 1998, defects were found in the gene for the tau protein, a substance that appears in the protein clots in the brains of FTD and Alzheimer's patients. In 2006, Christine Van Broeckhoven's team discovered hereditable defects in the gene for the progranulin protein. They predicted that people with these hereditable defects produce only half of the normal amount of progranulin.

This has been confirmed by Christine Van Broeckhoven's team, who have shown that a shortage of this growth factor leads to the dying off of brain cells in the frontal lobe and in this way causes FTD. New results indicate that progranulin also plays a role in the death of brain cells in other diseases of the brain, such as Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS).

Predictive test

On the basis of their research, Kristel Sleegers, a scientist in Van Broeckhoven's team, has developed a test for measuring the quantity of progranulin in the blood in a
'/>"/>

Contact: Sooike Stoops
sooike.stoops@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Penn research team tests bedside monitoring of brain blood flow and metabolism in stroke victims
2. Tiny tool to control growing blood vessels opens new potential in tumor research
3. Researcher seeks to turn stem cells into blood vessels
4. High-fat diets inflame fat tissue around blood vessels, contribute to heart disease
5. GEN reports on strategies to overcome blood-brain barrier
6. Cutting salt isnt the only way to reduce blood pressure
7. Statins may treat blood vessel disorder that can lead to fatal strokes
8. Genetic testing not cost-effective in guiding initial dosing of common blood thinner
9. Control of blood vessels a possible weapon against obesity
10. High blood sugars impact on immune system holds clues to improving islet cell transplants
11. Using the other guys toolkit: Similarities of pumping blood, oil examined
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... been studying the behavior of approximately 300 wild ... They observed that ravens slowly build alliances through ... they also observed that these affiliative interactions were ... about 50 % of the cases these interventions ... ravens, intervening can be potentially risky when the ...
(Date:10/30/2014)... Restoring wetlands can help reduce or reverse soil ... research in California,s Sacramento-San Joaquin River Delta by ... study, which is one of the first to ... methane as they cycle through wetlands, appears in ... . , Worldwide, agricultural drainage of organic ...
(Date:10/30/2014)... life, cells immediately begin accepting assignments to become a ... humans, are special. The cells of mammalian embryos get ... the protective placenta or to commit to forming the ... research from Michigan State University has revealed key discoveries. ... PLOS Genetics , provide insights into where ...
Breaking Biology News(10 mins):Dartmouth study finds restoring wetlands can lessen soil sinkage, greenhouse gas emissions 2Identifying the source of stem cells 2
... (NYSE: A) today introduced a high-performance ion trap ... life-science researchers to identify 60 to 80 percent ... such as protein identification and biomarker discovery, potentially ... cancer and speeding drug development efforts. The Agilent ...
... frequency of drug resistance in isolates of the AIDS ... urgent necessity. Host genes required to support the replication ... targets, but relatively few appropriate target genes have been ... conducted by Dr. Suzanne Sandmeyer and colleagues at the ...
... D. Anderson Cancer Center have developed a way to test ... chemotherapy drug Taxol are effectively killing tumor cells. They say ... to accurately assess whether patients are responding to these agents, ... , In two different studies being presented at the ...
Cached Biology News:Product improves peptide identification for proteomics research 2Study reveals candidate targets for anti-retroviral therapeutics 2Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol 2Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol 3
(Date:10/31/2014)... ENVIRON , an international environmental, ... Dr. Harvey Clewell III has rejoined the firm ... with senior professionals in ENVIRON’s Health Sciences practice. ... The Hamner Institutes for Health Sciences (The Hamner) ... is Director, Center for Human Health Assessment. , ...
(Date:10/30/2014)... Investor-Edge has initiated coverage on the following ... (NASDAQ: MDVN ), Pharmacyclics Inc. (NASDAQ: ... and Ironwood Pharmaceuticals Inc. (NASDAQ: IRWD). Free research on ... . On Wednesday, October 29, 2014, the ... Jones Industrial Average declined 0.18%, to finish the day ...
(Date:10/30/2014)... SoundConnect , an industry leading ... end users the key to turning this already ... adding voice enablement and hybrid audio conferencing. , ... communication tool that includes presence, instant messaging and ... becomes a comprehensive unified communications solution. Adding the ...
(Date:10/30/2014)... Avure Technologies celebrates a year of success and the ... fleet of high volume High Pressure Processing (HPP) systems. , ... to PackExpo this year, which is where we first announced ... Williams, CEO at Avure. “Sales of the new Avure machine ... the challenges of market demand for higher throughput. We sold ...
Breaking Biology Technology:Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3
... the price of soybean seed skyrocketing, soybean growers are looking for ... seeding rate. The research and education director of the North Central ... and profit potential in 2009. , ... Urbandale, Iowa ...
... (ASX: CYT) has today circulated a letter and ... shareholders. The letter provides an update on the ... 2009 and provides recommendations on how to vote ... 2009.(Photo: http://www.newscom.com/cgi-bin/prnh/20090225/NY75105 )The letter and the sample ...
... SEATTLE, Feb. 24 Implicit,Bioscience Ltd today announced ... Eli Lilly and Company. Implicit has paid an,undisclosed ... will also,receive a royalty on future IC14 sales. ... substantial expertise and passion to the,treatment of patients ...
Cached Biology Technology:NCSRP Research Director: "Earlier Planting can Increase Soybean Yields" 2NCSRP Research Director: "Earlier Planting can Increase Soybean Yields" 3Cytopia Letter to Progen Shareholders 2Cytopia Letter to Progen Shareholders 3Cytopia Letter to Progen Shareholders 4Cytopia Letter to Progen Shareholders 5Implicit Licenses Clinical Stage Antibody Program From Lilly 2Implicit Licenses Clinical Stage Antibody Program From Lilly 3
... The Human Genetic Cell Bank Service ... ECACC is based on Epstein-Barr Virus (EBV) ... resulting in the production of lymphoblastoid cell ... banked, providing a renewable and expandable source ...
... Panorama Mouse/Rat Tissue Extract Protein Array Kit ... various tissue extracts. The expression of a ... a protein specific antibody. When the antibody ... by a sensitive chemiluminescent or fluorescent signal ...
Glycerol-based mounting medium for immunofluorescence microscopy. Formulated to retard photobleaching of fluorochromes such as fluorescein and rhodamine. Product can also be used as a diluent for fl...
... medium is specifically formulated for mounting tissue ... been stained with immunohistochemical methods for viewing ... use with chromogens, such as AEC, that ... Faramount dries completely when slides are cover-slipped ...
Biology Products: