Navigation Links
Blood test predicts chance of dementia
Date:3/5/2009

Frontal lobe dementia

Frontal lobe dementia (Frontotemporal Dementia, FTD) strikes people at an earlier age. After Alzheimer's disease, FTD is the form of dementia that occurs most frequently in patients younger than 65. In FTD, the disease process starts in the frontal lobe where large numbers of brain cells begin to die off. The frontal lobe is the foremost part of the brain and constitutes about 30% of the brain. Among other things, it is involved in regulating behavior, movement and mood, and it is responsible for cognitive functions such as language. So, the first clinical signs of FTD are changes in behavior and personality, and then, in a later stage of the disease, the loss of memory functions.

Progranulin: a main actor

Genetic research has shown previously that there is a genetic defect in chromosome 17 in a large percentage of the families with FTD. There are two genes in chromosome 17 that, if a defect occurs, cause a hereditable form of FTD. In 1998, defects were found in the gene for the tau protein, a substance that appears in the protein clots in the brains of FTD and Alzheimer's patients. In 2006, Christine Van Broeckhoven's team discovered hereditable defects in the gene for the progranulin protein. They predicted that people with these hereditable defects produce only half of the normal amount of progranulin.

This has been confirmed by Christine Van Broeckhoven's team, who have shown that a shortage of this growth factor leads to the dying off of brain cells in the frontal lobe and in this way causes FTD. New results indicate that progranulin also plays a role in the death of brain cells in other diseases of the brain, such as Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS).

Predictive test

On the basis of their research, Kristel Sleegers, a scientist in Van Broeckhoven's team, has developed a test for measuring the quantity of progranulin in the blood in a simple way. This test enables one to determine whether someone has an increased risk of FTD due to a shortage of progranulin long before symptoms appear. The blood test can be used on a large scale and is much more simple and user-friendly than the current genetic tests. This finding also offers prospects for the early detection of FTD caused by a shortage of progranulin.

However, it is still too early for a medicine to combat FTD. Further scientific research is needed to determine how a shortage of progranulin can be restored to normal.


'/>"/>

Contact: Sooike Stoops
sooike.stoops@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related biology news :

1. Penn research team tests bedside monitoring of brain blood flow and metabolism in stroke victims
2. Tiny tool to control growing blood vessels opens new potential in tumor research
3. Researcher seeks to turn stem cells into blood vessels
4. High-fat diets inflame fat tissue around blood vessels, contribute to heart disease
5. GEN reports on strategies to overcome blood-brain barrier
6. Cutting salt isnt the only way to reduce blood pressure
7. Statins may treat blood vessel disorder that can lead to fatal strokes
8. Genetic testing not cost-effective in guiding initial dosing of common blood thinner
9. Control of blood vessels a possible weapon against obesity
10. High blood sugars impact on immune system holds clues to improving islet cell transplants
11. Using the other guys toolkit: Similarities of pumping blood, oil examined
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... 15, 2016  There is much more to innovative ... the engine. Continental will demonstrate the intelligence of today,s ... . Through the combination of the keyless entry ... biometric elements, the international technology company is opening up ... authentication. "The integration of biometric elements brings ...
(Date:12/12/2016)... Dec. 12, 2016  Researchers at Trinity College, ... graphene by combining the material with Silly Putty. The ... pressure detector able to sense pulse, blood pressure, ... spider.  The research team,s findings ... read here:  http://science.sciencemag.org/content/354/6317/1257 ...
(Date:12/8/2016)... Calif. , Dec. 8, 2016  Singulex, Inc., ... Molecule Counting technology, entered into a license and supply ... serving science. The agreement provides Singulex access to Thermo ... Europe is used to diagnose systemic ... United States to aid in assessing the ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... ... January 20, 2017 , ... The two newest companies ... options for patients. Vironika, a spin out from The Wistar Institute, and Sanguis, launched ... space at 3624 Market Street. , Vironika is developing a treatment for a ...
(Date:1/19/2017)... 2017 Research and Markets has announced the ... Cancer Type, Application - Global Opportunity Analysis and Industry Forecast, 2014-2022" ... ... market is projected to reach $15,737 million by 2022 from $6,521 ... 2022. Omic technologies segment accounted for more than ...
(Date:1/19/2017)... Basel, Switzerland (PRWEB) , ... ... ... leading provider of advanced software solutions for pharmaceutical research and development (R&D), ... project-based expertise in omic data analysis and interpretation for the rapidly evolving ...
(Date:1/19/2017)... ... 2017 , ... The American Medical Informatics Association (AMIA) today ... Policy. Specifically, the nation’s leading informatics experts, said data sharing plans should be ... recommended that NIH earmark funding for researchers to produce and execute data sharing ...
Breaking Biology Technology: