Navigation Links
Blood stem cell, leukemia link illuminated in UCSF-led study
Date:8/16/2010

A UCSF-led team has discovered at least one key reason why blood stem cells are susceptible to developing the genetic mutations that can lead to adult leukemia. Their finding also may explain, they say, why some other age-related hematological disorders develop.

The study, reported in "Cell Stem Cell" (Aug. 6, 2010) and reviewed in Cell Stem Cell and Cell, opens a new frontier for studying the molecular underpinnings of adult leukemia.

The discovery also suggests a possible therapeutic strategy, the scientists say, for reducing the risk of leukemia that results from chemotherapy used to treat solid tumors.

Finally, it may explain why other types of adult stem cells are susceptible to accumulating potentially lethal mutations.

Blood stem cells, located in the bone marrow, give rise to all blood cells of the body, such as red blood cells, white blood cells, and platelets. During fetal development, the stem cells specialize, or differentiate, into these various cell types. During life, they incessantly repeat the process, replacing old or depleted blood cells. The population also continuously self-renews.

Like most other adult stem cells, blood stem cells maintain a resting, or "quiescent," state when they are not differentiating or self-renewing. They do so to minimize stress caused by cellular respiration and errors in DNA replication, which can lead to DNA damage.

In the current study, conducted in the culture dish and mice, the team set out to determine if blood stem cells in the quiescent state were at greater risk for incurring genetic mutations in the process of repairing damaged DNA than were proliferating cells. Scientists have known that defects in DNA repair processes are associated with cancers, though they have known little about the mechanisms.

The team determined that both quiescent and proliferating blood stem cells have protective mechanisms ensuring their sur
'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. An IRCM researcher pinpoints the cellular mechanism responsible for modulating the permeability of blood vessels
2. UT Southwestern researchers find key step in bodys ability to make red blood cells
3. Red blood cells have a tiny but effective protector -- microRNA
4. Rare and common genetic variations responsible for high triglyceride levels in blood
5. Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents
6. UT MD Anderson study ties abnormal cells in blood to lung cancer
7. Adaptation in mole blood aids tunnelling
8. Toward making extended blood group typing more widely available
9. Pitt researchers find new proteins that regulate blood pressure, flow
10. For lambs, a pasture a week keeps blood suckers away
11. Waters unexpected role in blood pressure control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) ... Market in the APAC Region 2015-2019"  report to ... emerging in this market is advances in technology. ... to upgrade biometric solutions to the latest standard ...
(Date:12/10/2014)...  Valencell, a leader in performance biometric data sensor ... from its licensees for highly accurate, clinically validated biometric ... coming from fitness and health sectors, but first responders/military ... is only as useful as the biometric data it ... in long-term mass consumer adoption of wearable products," said ...
(Date:12/5/2014)... 4, 2014 Increased emphasis on product ... new testing and inspection technologies. The convergence of ... a range of innovative test solutions. This trend ... Y, which is generally more inclined towards communication, ... development strategies of test equipment vendors will cater ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... a gene that causes some one-celled sea creatures to ... that produce deadly red tides, has been successfully culminated ... DeCoursey, PhD, professor of biophysics and physiology at Rush ... tiny marine organism called a dinoflagellate ( Karlodinium veneficum ...
... Increasing acidification in coastal waters could compromise the ability ... keep their shells, according to a new study led ... be published in the November 2011 issue of ... of fertilizer runoff carried by the Mississippi River to ...
... investigated the cycling of molybdenum (Mo) in ancient oceans ... in sedimentary rocks from Grand Canyon that formed in ... Dahl, who did this research in collaboration with researchers ... Center of Earth Evolution in Denmark (NordCEE). ...
Cached Biology News:Discovery illuminates elusive proton channel gene in dinoflagellates 2Discovery illuminates elusive proton channel gene in dinoflagellates 3Run-off, emissions deliver double whammy to coastal marine creatures, UGA study finds 2Poisonous oceans delayed animal evolution 2
(Date:12/19/2014)... Diego, CA (PRWEB) December 18, 2014 ... a limited time special on Sartorius Biohit products ... Free on mLINE pipettes, Picus Electronic Pipette Trade-in Program, ... by Health and Safety officers around the world. They ... manual pipetting. Other features include:, ,     Full ...
(Date:12/19/2014)... , Dec. 18, 2014   ISN ... & Safety Performance Indicators publication series. With ... of activity reported in 2013 within its online contractor ... and safety key performance indicator (KPI) statistics. ... Clients, U.S. publication is available in two ...
(Date:12/17/2014)... Based on the revenues gained from surgical imaging ... by four major players contributing to approximately 74% ... GE Healthcare (U.K.), Siemens AG (Germany), Philips (Netherlands), ... Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , The leading ... its strong product portfolio, which includes its flagship ...
(Date:12/17/2014)... Ipsen Biopharmaceuticals, Inc., an affiliate ... IPSEY), today announced that Somatuline® Depot® (lanreotide) ... approved by the U.S. Food and Drug Administration ... (GEP-NETs) in adult patients with unresectable, well or ... improve progression-free survival (PFS). , “The approval of ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8
... , , , , ... future of Warsaw, Indiana, the orthopedics capital of the world, received ... awarded in the region. , , The Kosciusko ... grant, made by Lilly Endowment Inc. to KCCF, will support the ...
... , , BRIDGEWATER, N.J., Sept. 23 ... meeting logistics, speaker programs and commercial compliance management software for ... the 2009 InformationWeek 500 List of Top Technology ... Media,s first year on this prestigious list of the country,s ...
... , , EXTON, Pa., Sept. ... North America, announced today that it was awarded $843,289 in ... (NIAID), part of the National Institutes of Health, to support ... toxin(s)(1). , , Morphotek is ...
Cached Biology Technology:Lilly Endowment Awards $7 Million Grant to Establish Orthopedics and Community Initiative in Kosciusko County, IN 2Lilly Endowment Awards $7 Million Grant to Establish Orthopedics and Community Initiative in Kosciusko County, IN 3Lilly Endowment Awards $7 Million Grant to Establish Orthopedics and Community Initiative in Kosciusko County, IN 4Lilly Endowment Awards $7 Million Grant to Establish Orthopedics and Community Initiative in Kosciusko County, IN 5Advanced Health Media Named to 2009 InformationWeek 500 List of Top Technology Innovators Across America 2Advanced Health Media Named to 2009 InformationWeek 500 List of Top Technology Innovators Across America 3Advanced Health Media Named to 2009 InformationWeek 500 List of Top Technology Innovators Across America 4Morphotek(R), Inc. Awarded Funding to Develop Therapeutic Antibodies Against Potential Biowarfare Toxins 2
...
... A perfect complement to high-speed analytical techniques, the AutoTrace SPE is a powerful, ... the cartridge conditioning, sample loading and elution steps for large volumes aqueous solution ... ... ...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
... produced by a patented microwave process which ... consistent, even cell attachment, increased cell growth ... growth uunder difficult conditions, including reduced serum ... a more ecominic alternative to expensive and ...
Biology Products: