Navigation Links
Blood-flow metabolism mismatch predicts pancreatic tumor aggressiveness
Date:8/25/2009

PHILADELPHIA Researchers from Turku, Finland, have identified a blood-flow glucose consumption mismatch that predicted pancreatic tumor aggressiveness, according to results of a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Based on these findings, they suggested that the relationship between several physiological tumor parameters might provide more important information about a tumor than just looking at any of these parameters alone.

Gaber Komar, M.D., research fellow at the Turku PET Center, and colleagues investigated the importance of two physiological parameters in the tumor microenvironment among patients with pancreatic tumors to evaluate tumor aggressiveness. The parameters measured were blood flow in the tumor tissue and glucose consumption, which could be seen as a measurement of general metabolic activity of a tissue.

"Imaging of several of these tumor parameters might be important for the planning and success of oncologic therapies," Komar said. "We believe that a better understanding of these mechanisms may help overcome the general treatment resistance of pancreatic cancer."

The researchers used positron emission tomography (PET), a nuclear medicine imaging technique that provides a three-dimensional image of a bodily process, to measure blood flow and glucose consumption in 26 patients with pancreatic cancer. A PET scan is most often used to detect cancer and is also used to evaluate cancer response. It is emerging as a tool for pre-therapy evaluation of tumors and allows researchers to study and quantify tumor characteristics while the tumor is still in the body.

Results showed that patients with benign (n=8) and malignant (n=11) tumors had decreased blood flow of the lesion by 48 percent and 60 percent compared to patients with normal pancreatic tissue (n=7). These findings may help explain the lack of success some patients experience with radiotherapy and chemotherapy, the researchers suggested.

Komar said he was somewhat surprised by the results of the study since they did not expect to see such a clear correlation in such a small sample size.

"The important new step in the future might be the integration of these findings in management of a single tumor and combination of this information with the appropriate therapeutic approach including early monitoring of tumor responsiveness," Komar said.

David Mankoff, M.D., Ph.D., professor of radiology, medicine and bioengineering at the University of Washington and an academic physician at the Seattle Cancer Care Alliance, said this is the latest finding in a series of studies that have shown that a blood-flow metabolism mismatch in tumor is a sign of a resistant tumor and a predictor of bad outcome.

"This study confirms that blood flow metabolism mismatch exists in pancreatic tumors, similar to other cancers such as breast and lung cancers, and predicts poor patient outcome," said Mankoff. "A blood-flow metabolism mismatch by PET appears to be associated with cancer aggressiveness and treatment resistance. We've only recently recognized this pattern as a result of advantages in functional imaging methods."

Mankoff, who is also an editorial board member for the AACR's journal Clinical Cancer Research, said he believes this study has a few implications. As researchers begin to use new methods, such as PET imaging to explore in vivo biology, they may uncover factors that point towards behavior that is more aggressive and suggests new avenues for treatment, therefore leading to better patient outcome. For example, Mankoff said that the findings identified by Komar and colleagues may lead researchers to study the role that tumor tissue oxygenation and hypoxia play in mediating tumor clinical behavior and responsiveness to systemic therapy.


'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

Related biology news :

1. Abnormal fat metabolism underlies heart problems in diabetic patients
2. Dominant cholesterol-metabolism ideas challenged by new research
3. Cholesterol metabolism links early- and late-onset Alzheimers disease
4. A mechanism to explain biological cross-talk between 24-hour body cycle and metabolism
5. Small RNA plays parallel roles in bacterial metabolism
6. Engineer to spearhead research into cell metabolism and medical injuries
7. Circadian rhythm-metabolism link discovered
8. Making metabolism more inefficient can reduce obesity
9. Ecologists say metabolism accounts for why natural selection favors only some species
10. SNPs affect folate metabolism in study of Puerto-Rican adults
11. Toward a systems biology map of iron metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blood-flow metabolism mismatch predicts pancreatic tumor aggressiveness
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("Prometic" or the ... ("ILC") 2017 of the European Association for the Study of ... the positive effects of PBI-4050 on reduction of non-alcoholic steatohepatitis ... ... Gagnon, Vice-President of R&D Pre-clinical of Prometic "This extensive preclinical ...
(Date:4/20/2017)... and PETACH TIKVAH, Israel , April 20, ... developer of adult stem cell technologies for neurodegenerative diseases, announced ... present at the Alliance for Regenerative Medicine,s (ARM) 5 th ... April 27, 2017 at 09:40 EDT in Boston ... , MD, MHSc, Chief Medical Officer & Chief Operating Officer, ...
(Date:4/19/2017)... ... April 18, 2017 , ... ... . The move comes after the company changed focus to making analytical tools ... brand and our new technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert ...
(Date:4/19/2017)... PUNE, India , April 19, 2017 ... Global Opportunity Analysis and Industry Forecast, 2014-2022 ," the global market was valued ... 2022, registering a CAGR of 9.6% from 2016 to 2022. ... ...      ...
Breaking Biology Technology: