Navigation Links
Blood-brain barrier building blocks forged from human stem cells
Date:6/24/2012

s described in the new Wisconsin study, which was led by Ethan S. Lippmann, now a postdoctoral fellow at the Wisconsin Institute for Discovery, and Samira M. Azarin, now a postdoctoral fellow at Northwestern University, exhibit both the active and passive regulatory qualities of those cells that make up the capillaries of the intact brain.

The research team coaxed both embryonic and induced pluripotent stem cells to form the endothelial cells of the blood-brain barrier. The use of induced cells, which can come from patients with specific neurological conditions, may be especially important for modeling disorders that compromise the blood-brain barrier. What's more, because the cells can be mass produced, they could be used to devise high-throughput screens for molecules that may have therapeutic value for neurological conditions or to identify existing drugs that may have neurotoxic qualities.

"The nice thing about deriving endothelial cells from induced pluripotent stem cells is that you can make disease-specific models of brain tissue that incorporate the blood-brain barrier," explains Sean Palecek, a UW-Madison professor of chemical and biological engineering and a senior author of the new report. "The cells you create will carry the genetic information of the condition you want to study."

The generation of the specialized blood-brain barrier endothelial cells, the Wisconsin researchers note, has never been done with stem cells. In addition to the potential applications to screen drugs and model pathologies of the blood-brain barrier, they may also provide a novel window for developmental biologists who are interested in how the barrier comes together and co-develops with the brain.

"Neurons develop at the same time as the endothelial cells," Shusta says, noting that, in development, the cells secrete chemical cues that help determine organ specificity.

"We don't know what all those factors are," Lippmann says. "But
'/>"/>

Contact: Terry Devitt
trdevitt@wisc.edu
608-262-8282
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UTHealth study addresses barriers to physical activity counseling
2. Misperception of weight is an important barrier to weight loss
3. New study shines light on barriers to diabetes care in NYC Bangladeshi community
4. Stealing lifes building blocks
5. A cells first steps: Building a model to explain how cells grow
6. CUNY Energy Institute battery system could reduce buildings electric bills
7. Light weights are just as good for building muscle, getting stronger, researchers find
8. New study finds a protein combination is best to consume post-workout for building muscle
9. Building the European Unions Natura 2000 -- the largest ever network of protected areas
10. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
11. Photograph of a living human brain is the overall winner of Wellcome Image Awards 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... . Our eyes ... us with a continuous stream of information about our own ... in a car the world glides by us and ... effort, our brain calculates self-motion from this "optic flow". This ... gaze during our own movements. Together with biologists from the ...
(Date:4/17/2014)... One day about eight years ago, Katia ... Riverside, and her father were on a field trip in ... an orchid they had never seen before. , Unable to ... orchids. The orchid turned out to be an unnamed ... Lophiaris silverarum . , "Lophiaris" is the genus name, comprising ...
(Date:4/17/2014)... that devastate honeybees in Europe, Asia and the United ... appear to be impacting native honeybee populations at this ... invasive pests include including Nosema microsporidia and ... to be resilient to these invasive pests, which suggests ... in Europe, Asia and the United States currently are ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... Scientists from the UK and Australia have seen the ... in action for the first time. The UK team, funded ... the Wellcome Trust, is based at Birkbeck College where ... perforin uses to punch holes in rogue cells. The research ...
... surface is 30 percent more acidic today than it was in ... - a rising trend that could both harm coral reefs and ... food web, scientists warn. Despite the seriousness of such changes ... complete suite of available tools to monitor rising acidification and other ...
... of ancient Earth with wingspans of up to 70 ... atmospheric levels in the atmosphere in the past. New ... have confirmed that dragonflies grow bigger with more oxygen, ... larger when oxygen was higher in the past. For ...
Cached Biology News:Immune system assassin's tricks visualised for the first time 2Speed installation of system to monitor vital signs of global ocean, scientists urge 2Speed installation of system to monitor vital signs of global ocean, scientists urge 3Speed installation of system to monitor vital signs of global ocean, scientists urge 4Speed installation of system to monitor vital signs of global ocean, scientists urge 5Speed installation of system to monitor vital signs of global ocean, scientists urge 6Speed installation of system to monitor vital signs of global ocean, scientists urge 7Speed installation of system to monitor vital signs of global ocean, scientists urge 8Raising giant insects to unravel ancient oxygen 2Raising giant insects to unravel ancient oxygen 3
(Date:1/15/2014)... (PRWEB) January 15, 2014 Look inside ... hard-working items for the lab, from fluid handling to ... (GIS)—ready to ship when you order. , Preferred ... Pumps , from the L/S® model for precise flow ...
(Date:1/15/2014)... 2014 A study has been launched to ... 1 track could help to tackle the problem of obesity. ... (a GP surgery based in Stowmarket) and academics at University ... Telemetry technology, which is inspired by equipment used to ...
(Date:1/15/2014)... 2013 was a banner year of continued ... saw continued independent research led by the team at ... $1 million grant from the Susanne Marcus Collins Foundation, ... peer reviewed journal, Amy Grant highlighted Brainwave Optimization® in ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... NEW YORK, Oct. 24, 2011 Celgene Corporation (Nasdaq: ... as its Focus Stock of the Week.  CELG carries ... Strong Buy. "We consider Celgene to be ... solid core product growth," said Steven Silver, Biotech Equity ...
... (Nasdaq: PCRX ), an emerging specialty pharmaceutical company, ... ended September 30, 2011 will be released before the market ... will host a conference call to discuss the company,s financial ... 2011 at 9 a.m. ET. The call can be accessed ...
... who developed a novel mouse model mimicking human preterm labor ... targeted it to stop the problem.   (Logo: ... published online the week of Oct. 24 by PNAS ... the researchers report their findings may lead to new strategies ...
Cached Biology Technology:S&P Capital IQ Picks Celgene Focus Stock of the Week 2S&P Capital IQ Picks Celgene Focus Stock of the Week 3Pacira Pharmaceuticals, Inc. Announces Timing for Third Quarter 2011 Financial Results Webcast and Conference Call 2Pacira Pharmaceuticals, Inc. Announces Timing for Third Quarter 2011 Financial Results Webcast and Conference Call 3Study Hints at Possible Therapeutic Strategy to Combat Premature Birth 2Study Hints at Possible Therapeutic Strategy to Combat Premature Birth 3