Navigation Links
Blocking tumor-associated macrophages decreased glioblastoma's growth & extended survival in mice
Date:12/15/2013

An experimental drug that targets macrophages, a type of immune cells, in the microenvironment surrounding the lethal brain tumor glioblastoma multiforme decreased the cancer's growth and extended survival of laboratory mice with the cancer, scientists will report on Tuesday Dec. 17, at the American Society for Cell Biology (ASCB) annual meeting in New Orleans.

The rates of apoptosis, or programmed cell death, were higher in the mice treated with the experimental agent than in the untreated animals that also had high-grade glioblastomas, said Johanna Joyce, Ph.D., of the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City. As a result, the drug-treated laboratory mice survived many months longer than the untreated animals with the same cancer.

The experimental drug blocks cell receptors for colony-stimulating factor-1 (CSF-1R), which is essential to the differentiation and survival of tumor-associated macrophages and microglia (TAMS), which are the brain's front-line immune defense cells. The microenvironment that surrounds brain tumors contains many macrophages with this receptor.

Glioblastoma multiforme (GBM) is the most common and the most deadly adult primary brain tumor, with an average survival of just 14 months following diagnosis. Even with aggressive treatment by surgery, radiation and chemotherapy, most therapeutic approaches targeting the glioma cells in GBM fail.

Faced with this bleak picture, Dr. Joyce and colleagues MSKCC looked for an alternative strategy and turned to the cancer's cellular neighbors, the non-tumor cells that are part of the glioma microenvironment. In particular, they zeroed in on tumor-associated macrophages and TAMs.

When Dr. Joyce's lab used an inhibitor of the CSF-1 receptor (CSF-1R) to target TAMs in a mouse model of GBM, the treated mice survived many months longer than the control cohort. Their established, high-grade gliomas regressed in proliferation and maligna
'/>"/>

Contact: Cathy Yarbrough
cyarbrough@ascb.org
858-243-1814

John Fleischman
jfleischman@ascb.org

American Society for Cell Biology
Source:Eurekalert


Page: 1 2

Related biology news :

1. Pathogen study explores blocking effect of E. coli O157:H7 protein
2. Newly identified proteins make promising targets for blocking graft-vs.-host disease
3. Study suggests way to fight therapy resistant leukemia by blocking DNA repair
4. Blocking overactive receptor in Alzheimers recovers memory loss and more
5. Drug reduces fat by blocking blood vessels
6. Blocking DNA: HDAC inhibitor targets triple negative breast cancer
7. Study finds depletion of alveolar macrophages linked to bacterial super-infections
8. Practice Fusion Raises Additional $15M to Close Year of Exponential Platform Growth
9. High cholesterol fuels the growth and spread of breast cancer
10. Methylation signaling controls angiogenesis and cancer growth
11. Plant cell architecture: Growth toward a light source
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... to acquire and creatively manipulate spoken language is unique ... past 6 million years of human evolution to make ... best candidate gene we now have," says Wolfgang Enard, ... his efforts to understand the molecular biological basis of ... The results of his latest study, undertaken in collaboration ...
(Date:9/18/2014)... its newborn screening program into a model other states can ... first-ever Newborn Screening Quality Award from the March of Dimes. ... Arizona,s Department of Health Services director, with the award at ... of full transparency for the length of time it takes ... for analysis, and set a target of having 95 percent ...
(Date:9/18/2014)... tonight at the third annual Golden Goose Award ceremony ... infants and in paving the way for the telecommunications ... by the National Science Foundation, the National Institutes of ... honored at a ceremony at the Library of Congress ... Congress will be on hand to help present their ...
Breaking Biology News(10 mins):Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 33rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2
... created genetic circuits in bacterial cells that not only perform ... in the cell,s DNA and passed on for dozens of ... edition of Nature Biotechnology , could be used as ... stem cells to differentiate into other cell types. "Almost ...
... as programmable robots, researchers at Rice University hope to someday ... feed the brain and help people regain functions lost to ... colleagues simulate patterns of microvasculature cell growth and compare the ... want to develop the ability to control the way these ...
... have found that one of the most aggressive invasive ant ... appears to have met its match in the Asian needle ... ant is successfully displacing Argentine ants in an urban environment, ... sting may be the next invasive species to see ...
Cached Biology News:Cell circuits remember their history 2Cell circuits remember their history 3Rice University lab show how blood vessels regroup after stroke 2Rice University lab show how blood vessels regroup after stroke 3Researchers find Asian needle ants displacing other aggressive invaders 2
(Date:9/19/2014)... Sept. 19, 2014  InterMune, Inc. (Nasdaq: ... Memorandum of Understanding to settle the litigation in the ... Plan of Merger dated as of August 22, 2014, ... Inc.  As one term of the Memorandum of Understanding, ... forth in the attached exhibit reflecting the amendment to ...
(Date:9/19/2014)... crop yields to disease risks, the biological characteristics people ... Just as for heightthe textbook example of a complex ... shaped by multiple genetic and environmental influences, making it ... such genes, geneticists typically mate two individuals that differ ... small mouseand then study their descendents, looking for genes ...
(Date:9/19/2014)... September 18, 2014 Scientists at NYU Langone Medical ... the efficiency of the process for turning adult cells ... compounds, including vitamin C. Using the new technique in ... obtained from adult skin cells by more than 20-fold ... is efficient and reliable, and thus should generally accelerate ...
(Date:9/19/2014)... use light, rather than electricity, to move data ... efficiency is a growing concern as chips, transistor ... of optical circuits light emitters, modulators, and ... One promising light source for optical chips is ... when deposited as a single, atom-thick layer. Other ...
Breaking Biology Technology:InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19Want to link genes to complex traits? Start with more diversity 2NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3Toward optical chips 2Toward optical chips 3
... Roche (SIX: RO, ROG; Pink Sheets: RHHBY ) ... use on the cobas s 201 system is now ... quantify parvovirus B19 and detect hepatitis A virus (HAV) simultaneously in ... used to create treatments for life-threatening and chronic diseases and disorders ...
... layered materials to give atom thin "nanosheets" has been ... two-dimensional nanomaterials with chemical and electronic properties that have ... technologies. The collaborative* international research led by the ... Trinity College Dublin, Ireland, and the University of Oxford ...
... 3, 2011 Codexis, Inc. (Nasdaq: CDXS ... and year ended December 31, 2010.   ... to $107.1 million, driven by a 77% increase in ... to $32.8 million in 2010, and increases in collaborative ...
Cached Biology Technology:First Duplex Test for Parvovirus B19 and Hepatitis A Virus Now Available in the US 2New nanomaterials unlock new electronic and energy technologies 2Codexis Reports Fourth Quarter and Full Year 2010 Results 2Codexis Reports Fourth Quarter and Full Year 2010 Results 3Codexis Reports Fourth Quarter and Full Year 2010 Results 4Codexis Reports Fourth Quarter and Full Year 2010 Results 5Codexis Reports Fourth Quarter and Full Year 2010 Results 6Codexis Reports Fourth Quarter and Full Year 2010 Results 7Codexis Reports Fourth Quarter and Full Year 2010 Results 8
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human CD69 TAC is designed to deplete human CD69 from samples to isolate resting CD4+ or CD8+ T cells....
This bispecific antibody complex has been tested for efficient depletion of CD41+ cells using the StemSep ; negative immunomagnetic cell separation system....
... a modular confocal system that gives you ... and lightweight design. The improved scan head ... to 400nm andits bi-directional scanner provides faster ... and Y scan axes rotation and new ...
... is an integrated digital microscope and camera ... equipment setup, optical adjustment or software installation. ... technology, COOLSCOPE combines simplicity and advanced technology ... offers simultaneous viewing of a macro image ...
Biology Products: