Navigation Links
Blocking rogue gene could stop the spread of most cancers
Date:1/24/2011

Scientists at the University of East Anglia (UEA) have discovered a rogue gene which if blocked by the right drugs could stop cancer in its tracks.

Published today by the journal Oncogene, the discovery is a breakthrough in our understanding of how cancer spreads. It is hoped the research will lead to new drugs that halt the critical late stage of the disease when cancer cells spread to other parts of the body.

The culprit gene known as WWP2 - is an enzymic bonding agent found inside cancer cells. It attacks and breaks down a natural inhibitor in the body which normally prevents cancer cells spreading. The UEA team found that by blocking WWP2, levels of the natural inhibitor are boosted and the cancer cells remain dormant. If a drug was developed that deactivated WWP2, conventional therapies and surgery could be used on primary tumours, with no risk of the disease taking hold eleswhere.

Lead author Andrew Chantry, of UEA's School of Biological Sciences, said the discovery could lead to the development of a new generation of drugs within the next decade that could be used to stop the aggressive spread of most forms of the disease, including breast, brain, colon and skin cancer.

"The late-stages of cancer involve a process known as metastasis - a critical phase in the progression of the disease that cannot currently be treated or prevented," said Dr Chantry.

"The challenge now is to identify a potent drug that will get inside cancer cells and destroy the activity of the rogue gene. This is a difficult but not impossible task, made easier by the deeper understanding of the biological processes revealed in this study."

The research was funded by UK-based charity the Association of International Cancer Research (AICR), with additional support from the Big C Charity and the British Skin Foundation.

Dr Mark Matfield, scientific co-ordinator of AICR, said: "This is a very exciting new discovery a
'/>"/>

Contact: Simon Dunford
s.dunford@uea.ac.uk
44-160-359-2203
University of East Anglia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Blocking the critical structure that lets cancer cells move -- their feet
2. Tiny RNA molecules control labor, may be key to blocking premature birth
3. Cranberry juice shows promise blocking Staph infections
4. How blocking the Programmed Death 1 protein may treat or prevent sepsis and severe infection
5. Blocking cancer in its path: New cellular defect discovered
6. Blocking cell movement for cancer, MS treatment
7. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
8. How do we kill rogue cells?
9. iGEM team helps prevent rogue use of synthetic biology
10. Oregons Rogue River Basin to face climate-change hurdles
11. Could oysters be used to clean up Chesapeake Bay?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... to survive? The answer changes depending on climate, and some ... sprouts. Stanford researchers have found that the formation of ... meaning mouth) is controlled by a specific signaling pathway that ... The findings are described in a paper published Nov. 14 ...
... Nov. 24 M2SYS Technology, an award-winning,fingerprint ... that,InvoTech Systems Inc., the leading provider of ... industry, has chosen M2SYS Technology to,provide ... software and with M2SYS, M2-EasyScan(TM) optical fingerprint,reader. ...
... (NIST) announced today that it is awarding grants totaling ... cost-shared support for the construction of new scientific research ... in a special competition announced last spring. The ... the University of California at Berkeley for the build-out ...
Cached Biology News:Key link in how plants adapt to climate discovered by Stanford researchers 2InvoTech Selects M2SYS Technology for Leading-Edge Fingerprint Software Solution 2NIST awards $24M in grants for new research facilities 2NIST awards $24M in grants for new research facilities 3NIST awards $24M in grants for new research facilities 4NIST awards $24M in grants for new research facilities 5
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a ... check the legal requirements around using controlled substances in ... , As their international operations expand and become increasingly ... built as a result of the first phase of ...
(Date:1/22/2015)... Diagenode, Inc., a leading global ... and complete solutions for epigenetics research, recently launched ... the need for manual processing. The new ChIPettor ... of histones or transcription factors and a semi-automated ...
(Date:1/22/2015)... Jan. 22, 2015   Cypher Genomics, Inc., ... (NASDAQ: SQNM ), the leading molecular ... next generation noninvasive prenatal tests (NIPT). Through this ... called Mantis™, to advance analysis of clinically-relevant fetal ...
(Date:1/22/2015)... Jan. 22, 2015   GenoSpace , a precision medicine software ... enable the broad use of genomic, imaging and other biomedical ... of Michelle Munson , CEO of Aspera, an IBM ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We are ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2
... February 29, 2012 TREM Rx, Inc., a biotechnology ... to the skin, announced today the results of an in ... powerful cells of the immune system called TREMs (T Resident ... protective immune response that is far stronger than memory T ...
... has been shown to significantly improve the chances of pregnancy ... a Newcastle team of fertility experts at the University and ... a totally enclosed and controlled environment within which every step ... published today in the journal PLoS ONE reveals ...
... 2012 ARUP Laboratories, a leading national clinical and ... laboratory research and development, announced the establishment of a ... ) The new division is designed to ... enhance our ability to diversify into new market segments. ...
Cached Biology Technology:Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 2Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 3Increased fertility rate for IVF patients achieved by new equipment design 2ARUP Laboratories Announces Creation of Business Innovations Division 2
...
Agarose-LE, 250 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Request Info...
Biology Products: