Navigation Links
Blocking overactive receptor in Alzheimer's recovers memory loss and more
Date:6/17/2013

This news release is available in French.

A new study shows that memory pathology in older mice with Alzheimer's disease can be reversed with treatment. The study by researchers from the Montreal Neurological Institute and Hospital - The Neuro, at McGill University and at Universit de Montral found that blocking the activity of a specific receptor in the brain of mice with advanced Alzheimer's disease (AD) recovers memory and cerebrovascular function. The results, published in the Journal of Neuroinflammation in May, also suggest an underlying mechanism of AD as a potential target for new therapies.

"The exciting and important aspect of this study is that even animals with advanced pathology can be rescued with this molecule" says Dr. Edith Hamel, neuroscientist at The Neuro and lead investigator on the paper in collaboration with Dr Rjean Couture at the Department of Physiology at Universit de Montral. "We have rarely seen this type of reversal of AD symptoms before in our mouse model at this advanced age when mice have been developing AD for one year."

The researchers found an increased level of a receptor known as bradykinin B1 receptor (B1R) in the brain of mice with AD, a receptor involved in inflammation. "By administering a molecule that selectively blocks the action of this receptor, we observed important improvements in both cognitive and cerebrovascular function," says Dr. Baptiste Lacoste, research fellow who conducted the study at The Neuro and now pursuing his training at Harvard Medical School in Boston. "Alzheimer's disease destroys nerve cells and also compromises the function of blood vessels in the brain. Not only were there improvements in learning and memory, but also marked recovery in blood flow and vascular reactivity, i.e. the ability of cerebral vessels to dilate or constrict when necessary." Proper functioning of blood vessels in the brain is vital to providing nutrients and oxygen to nerve cells, and vascular diseases represent important risk factors for developing AD at an advanced age.

"Another interesting result that has not been seen before in our mouse model is a reduction by over 50% of toxic amyloid-beta peptide," adds Dr. Hamel. "In Alzheimer's disease, protein fragments called amyloid-beta have a deleterious effect on the blood and nervous systems. Normally, these protein fragments are broken down and removed. In Alzheimer's disease, the protein fragments clump together a factor believed to contribute to neuronal and vascular dysfunction. We are not sure if these decreases contribute to the functional recovery, but we hope that our findings will aid in clarifying this issue and identifying new targets for therapeutic approaches."

The results show that an increase in B1R is associated with amyloid-beta plaques in Alzheimer's disease mice with impaired memory, and that chronic blockade of B1R significantly improves learning, memory, cerebrovascular function, and several other pathological AD hallmarks in mice with a fully developed pathology. Together, these findings confirm a role of B1R in AD pathogenesis and the role of neuroinflammation as an underlying mechanism in AD. The next step would be to further investigate potential blockers of the bradykinin B1R as a potential treatment for AD in humans.


'/>"/>

Contact: Anita Kar
514-398-3376
McGill University
Source:Eurekalert

Related biology news :

1. Blocking DNA: HDAC inhibitor targets triple negative breast cancer
2. Drug reduces fat by blocking blood vessels
3. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
4. G protein-coupled receptor mediates the action of castor oil
5. BUSM study identifies receptors role in regulating obesity, type 2 diabetes
6. Cell receptor has proclivity for T helper 9 cells, airway inflammation
7. Steroid hormone receptor prefers working alone to shut off immune system genes
8. Jackson Laboratory researchers provide definitive proof for receptors role in synapse development
9. Dopamine-receptor gene variant linked to human longevity
10. How the tilt of a cell-surface receptor prevents cancer
11. Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... , Jan. 24, 2017 Biopharm Reports ... the laboratory use of nuclear magnetic resonance spectroscopy ... end-users and profiled current practices, developments, trends and ... well as growth and opportunities. These areas include ... NMR instruments, needs and innovation requirements, hyphenated NMR ...
(Date:1/23/2017)...  The latest mobile market research from Acuity Market ... The quarterly average price of a biometric smartphone decreased ... 2016.  There are now 120 sub-$150 models on the ... just 28 a year ago at an average price ... Most , Acuity Market Intelligence Principal, "Biometric Smartphones are ...
(Date:1/19/2017)... , January 19, 2017 According to a new report ... Forecast, 2014 - 2022," the global biometric sensor market is expected to garner ... 2022. In 2015, Asia-Pacific dominated the global market and ... sectors. Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... and NEW YORK , ... Lumeon , a leading digital health company, ... a provider of telemedicine and remote patient monitoring, ... for telemedicine reimbursements.  DN Telehealth ... patients, in real-time, extending consultations beyond a physical ...
(Date:2/23/2017)... Atlanta, it seems everyone has a chance to express their ... expressive and dynamic community unlike any other. The businesses that ... With their newest salon in ... on that tradition with a unique, fresh approach to head ... the newest of 13 nationwide locations, each of them well-situated ...
(Date:2/23/2017)... Ind. (PRWEB) , ... February 23, 2017 , ... ... Award during the 12th annual Inventors Recognition Reception at Purdue Research Park ... to a faculty member in recognition of outstanding contributions to, and success with, ...
(Date:2/23/2017)... SAN DIEGO and SAN FRANCISCO ... , a privately-held regenerative medicine company, and Beyond Type ... living with type 1 diabetes, today announced a grant ... develop a functional cure for type 1 and other ... decade, ViaCyte has been developing innovative stem cell-derived cell ...
Breaking Biology Technology: