Navigation Links
Blocking inflammation could lead to tailored medical treatments
Date:9/19/2011

By using a mouse model of inflammation researchers at the University of Calgary have discovered a new class of molecules that can inhibit the recruitment of some white blood cells to sites of inflammation in the body. A provisional patent has been filed on these molecules by Innovates Calgary.

When there is inflammation in the body, one of the primary defense mechanisms is the movement of white blood cells, known as neutrophils, from the bloodstream into the infected tissue. Neutrophils are specialized cells that kill microbes associated with infection. Although neutrophils are important, their excessive recruitment into tissues can result in damage and contribute to disease.

Current anti-inflammatory drugs block all inflammation in the body. However, these newly discovered molecules target only neutrophils and may offer a more tailored course of treatment for some diseases, for example to help people suffering from inflammatory diseases such as Inflammatory Bowel Disease (IBD).

"This class of novel anti-inflammatory agents set the stage to develop drugs for conditions that have recurrent or chronic inflammation, " says Stephen Robbins, Ph.D, a researcher at the University of Calgary Faculty of Medicine, senior study author and the Director of the Southern Alberta Cancer Research Institute. "The next step in our research will be to test their effectiveness in preclinical studies of inflammatory diseases, including IBD"

"We are excited by the possibility that this research may be clinically useful to alleviate some of the damage that occurs in conditions where chronic inflammation leads to tissue injury," says Elizabeth Long PhD, who is also a University of Calgary researcher and study author.


'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1

Related biology news :

1. Blocking common gateway to inflammation suppresses cancer
2. Blocking crucial molecule could help treat multiple sclerosis, Jefferson neuroscientists say
3. Blocking rogue gene could stop the spread of most cancers
4. Blocking the critical structure that lets cancer cells move -- their feet
5. Tiny RNA molecules control labor, may be key to blocking premature birth
6. Cranberry juice shows promise blocking Staph infections
7. How blocking the Programmed Death 1 protein may treat or prevent sepsis and severe infection
8. Blocking cancer in its path: New cellular defect discovered
9. Blocking cell movement for cancer, MS treatment
10. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
11. Pitt team finds molecular pathway that leads to inflammation in asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... -- The rising popularity of mobility services such ... significant interest in keyless access systems. Following the ... (BLE), biometrics and near-field communication (NFC) are poised ... technologies in the automotive industry. This evolution from ... opens the market to specialist companies such as ...
(Date:12/16/2016)... Dec. 16, 2016   IdentyTechSolutions America LLC ... products and solutions and a cutting-edge manufacturer of ... it is offering seamless, integrated solutions that comprise ... products. The solutions provide IdentyTech,s customers with combined ... facilities from crime and theft. "We ...
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... (PRWEB) , ... January 11, 2017 , ... ... each year and costing healthcare systems more than $23.7 billion, healthcare systems ... costs. , Among the most common sepsis-causing pathogens are bacteria and the ...
(Date:1/11/2017)... ... January 11, 2017 , ... ... the difference when navigating the challenges young businesses face. With the second installment ... expertise and experience of Geoff DiMasi, Founder and Principal of interactive design agency, ...
(Date:1/11/2017)... , PITTSBURGH and BENGALURU, ... N.V. (NASDAQ, TASE: MYL) and Biocon Ltd. (BSE code: ... and Drug Administration (FDA) has accepted Mylan,s biologics license ... filing through the 351(k) pathway. This product is a ... treat certain HER2-positive breast cancers. The anticipated FDA goal ...
(Date:1/11/2017)... ... January 11, 2017 , ... KBioBox llc ... with Poseida Therapeutics Inc, the San Diego based specialist in gene and cell ... KBioBox in order to harness KBioBox’s powerful BioEngine Algorithms which do not compromise ...
Breaking Biology Technology: