Navigation Links
Blocking inflammation could lead to tailored medical treatments
Date:9/19/2011

By using a mouse model of inflammation researchers at the University of Calgary have discovered a new class of molecules that can inhibit the recruitment of some white blood cells to sites of inflammation in the body. A provisional patent has been filed on these molecules by Innovates Calgary.

When there is inflammation in the body, one of the primary defense mechanisms is the movement of white blood cells, known as neutrophils, from the bloodstream into the infected tissue. Neutrophils are specialized cells that kill microbes associated with infection. Although neutrophils are important, their excessive recruitment into tissues can result in damage and contribute to disease.

Current anti-inflammatory drugs block all inflammation in the body. However, these newly discovered molecules target only neutrophils and may offer a more tailored course of treatment for some diseases, for example to help people suffering from inflammatory diseases such as Inflammatory Bowel Disease (IBD).

"This class of novel anti-inflammatory agents set the stage to develop drugs for conditions that have recurrent or chronic inflammation, " says Stephen Robbins, Ph.D, a researcher at the University of Calgary Faculty of Medicine, senior study author and the Director of the Southern Alberta Cancer Research Institute. "The next step in our research will be to test their effectiveness in preclinical studies of inflammatory diseases, including IBD"

"We are excited by the possibility that this research may be clinically useful to alleviate some of the damage that occurs in conditions where chronic inflammation leads to tissue injury," says Elizabeth Long PhD, who is also a University of Calgary researcher and study author.


'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1

Related biology news :

1. Blocking common gateway to inflammation suppresses cancer
2. Blocking crucial molecule could help treat multiple sclerosis, Jefferson neuroscientists say
3. Blocking rogue gene could stop the spread of most cancers
4. Blocking the critical structure that lets cancer cells move -- their feet
5. Tiny RNA molecules control labor, may be key to blocking premature birth
6. Cranberry juice shows promise blocking Staph infections
7. How blocking the Programmed Death 1 protein may treat or prevent sepsis and severe infection
8. Blocking cancer in its path: New cellular defect discovered
9. Blocking cell movement for cancer, MS treatment
10. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
11. Pitt team finds molecular pathway that leads to inflammation in asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... have found that targeting a molecule in blood vessels ... research published in Nature today (Sunday)., The ... University of London, have found that a molecule, called ... itself after chemotherapy or radiotherapy, which kill cancer cells ... blood vessels that grew in melanoma or lung cancer ...
(Date:7/25/2014)... on the land now called California, and many of ... plants they used for food, fuel, tools, and ritual. ... habitat and natural resources. , Frank Lake, an ecologist ... lead a field trip to the Stone ... America,s 99th Annual Meeting, in Sacramento, Cal. this August. ...
(Date:7/25/2014)... published online in the International Journal of Cancer ... preventing cervical cancer based on findings showing successful reduction ... a discrete population of cells in the cervix. ... at squamocolumnar junction cells, or SCJ cells. These cells ... as the origins of cervical cancer. A research team ...
Breaking Biology News(10 mins):New drug target can break down cancer's barrier against treatment 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3Clearing cells to prevent cervical cancer 2
... outbreak of avian or "bird flu" lingers, health officials recognize ... the virus already have developed resistance to the current roster ... Diego scientists - with the help of resources at the ... - have isolated more than two dozen promising and novel ...
... University have found that quantum dot nanoparticles can penetrate ... into potential workplace concerns for healthcare workers or individuals ... research on potential biomedical applications of the tiny nanoparticles. ... different sizes, shapes and surface coatings do not penetrate ...
... German . , Metabolomics aims to determine the totality ... The exponents of bioinformatics analyzed data collected in the framework ... In each case, a subgroup of the animals was treated ... were quantitatively determined in a blood plasma sample of a ...
Cached Biology News:UC San Diego researchers identify potential new drug candidates to combat 'bird flu' 2UC San Diego researchers identify potential new drug candidates to combat 'bird flu' 3UC San Diego researchers identify potential new drug candidates to combat 'bird flu' 4Study shows quantum dots can penetrate skin through minor abrasions 2Healthy or diseased? 2
(Date:7/28/2014)... 2014   Propeller Health , the FDA-cleared digital ... of Brad Towle as Senior Vice President, ... driving the company,s sales growth, customer acquisition and program ... specifically his past role in the development of accountable ... this pivotal time in the industry," said David ...
(Date:7/28/2014)... , July 28, 2014  InterMune, Inc. (NASDAQ: ... release its second quarter 2014 financial results at the ... 2014. A live conference call and webcast will be hosted ... day. Interested investors and others may participate ... +1 212-231-2900 (international), conference ID#21728775. A replay of the webcast ...
(Date:7/26/2014)... Albany, NY (PRWEB) July 26, 2014 ... 2020 provides key market data on the Canada ... in millions of US dollars, volume (in units) ... segments - High-End Endoscopy Visualization Systems, Mid-Range Endoscopy ... Browse Full Report at http://www.marketresearchreports.biz/analysis/213254 . , ...
(Date:7/25/2014)... University of Leicester has furthered our understanding of ... create new materials using nanosized ,building blocks,. , ... prestigious academic journal Physical Review Letters , ... rich detail the structure and internal atomic motion ... and a single helium atom. , The technique ...
Breaking Biology Technology:Propeller Health Hires Brad Towle as Senior Vice President of Business and Client Development 2InterMune to Release Second Quarter Financial Results on August 6 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3
... artist Steven Seagal has written an open letter to Russian ... the "Russia 2045" movement that aims to make Russia the ... "Russia 2045," by using and developing new technologies, hopes to ... by the year 2045. "Not so long ago, ...
... Del., May 16, 2011 Children taking medication for ... heart problems or heart-related deaths than those who were ... online today in the journal, Pediatrics . ... the University of Pennsylvania and HealthCore Inc., drew data ...
... N.J., May 16, 2011 Palatin Technologies, Inc. (NYSE Amex: ... sexual dysfunction indications and PL-3994 for acute asthma and other ... 31, 2011. Recent Highlights ... Drug Administration (FDA), Palatin submitted a revised protocol to the ...
Cached Biology Technology:Steven Seagal Asks For Russian PM Vladimir Putin's Support in Immortality Research 2Pediatrics Study Finds Children Taking ADHD Medications Did Not Suffer More Serious Heart Problems or Cardiovascular-related Death 2Pediatrics Study Finds Children Taking ADHD Medications Did Not Suffer More Serious Heart Problems or Cardiovascular-related Death 3Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 2Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 3Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 4Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 5Palatin Technologies, Inc. Reports Third Quarter Fiscal Year 2011 Results 6
... 9001:2000 Certified USDA Research Registered OLAW Assured ... Training AALAS Certified Technicians Documentation ... Documentation Upon Request Focus CRP ... all your custom immunology service needs. ...
Request Info...
... include: ,ICC and IHC Protocol Development ... ,Antibody Screenings in Animal or Human ... of Cells and Tissues ,Peroxidase, Alkaline ... Fluorescent, or Electron Microscopy ,Protein Localization ...
Request Info...
Biology Products: