Navigation Links
Blocking crucial molecule could help treat multiple sclerosis, Jefferson neuroscientists say
Date:4/24/2011

PHILADELPHIAReporting in Nature Immunology, Jefferson neuroscientists have identified a driving force behind autoimmune diseases such as multiple sclerosis (MS), and suggest that blocking this cell-signaling molecule is the first step in developing new treatments to eradicate these diseases.

Researchers led by Abdolmohamad Rostami, M.D., Ph.D., Professor and Chairman of the Department of Neurology at Jefferson Medical College of Thomas Jefferson University, found that GM-CSF, which stands for Granulocyte-macrophage colony-stimulating factor, appears to be the key culprit in the onset of MS, because without it, T helper 17 cells (Th17) cells did not induce the MS-like disease in an experimental animal model.

Th17 cells have been shown to play an important pathogenic role in humans and experimental models of autoimmune diseases, but the mechanisms behind this have remained elusive until now.

"There was no connection between GM-CSF and Th17 cells before," said Dr. Rostami. "What we have shown in this paper is that GM-CSF derived from Th17 cells is important in the cell-signaling process that leads to inflammation in the central nervous system."

"Now we know how the Th17 cells work and a better understanding of this mechanism and biology leads to new therapeutics," he adds.

The results suggest that blocking GM-CSF activity may be a successful therapeutic strategy in MS, one of the most common neurological diseases affecting young adults, and other autoimmune diseases, said Dr. Rostami, who is also the Chair of Neurology at Thomas Jefferson University Hospital.

The paper first appe
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
2. Blocking cell movement for cancer, MS treatment
3. Blocking cancer in its path: New cellular defect discovered
4. How blocking the Programmed Death 1 protein may treat or prevent sepsis and severe infection
5. Cranberry juice shows promise blocking Staph infections
6. Tiny RNA molecules control labor, may be key to blocking premature birth
7. Blocking the critical structure that lets cancer cells move -- their feet
8. Blocking rogue gene could stop the spread of most cancers
9. Hidden infections crucial to understanding, controlling disease outbreaks
10. Mayo researchers identify dangerous two-faced protein crucial to breast cancer spread and growth
11. In lung cancer, silencing one crucial gene disrupts normal functioning of genome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blocking crucial molecule could help treat multiple sclerosis, Jefferson neuroscientists say
(Date:11/4/2014)... University School of Medicine announced today that it ... funded by the Bill & Melinda Gates Foundation. ... Gynecology and Reproductive Sciences; and Vice Chair of ... of Medicine will pursue an innovative global health ... to Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) ...
(Date:11/4/2014)... published research study examining only marketing directed at ... food restaurants has found that the majority of ... to such marketing tactics. , Authored by Arizona ... the study is the first to examine the ... exterior of fast food restaurants and its relationship ...
(Date:11/4/2014)... majority of Madagascar,s 101 species of lemurs are threatened ... the rainforests they call home. A new study by ... have on rainforest tree populations, which raises concerns about ... region,s rich biodiversity. , A large proportion of trees ... Lemurs in turn disperse the seeds of their fruit ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... many centuries, sustained major fisheries on both sides of ... largely collapsed. A new paper in the open-access, peer-reviewed ... University of Iceland and Marine Research Institute in Reykjavik ... fisheries, due to fisheries-induced evolution. Cod fishing is ...
... Prevention Research (SPR) will hold its annual meeting, May ... Avenue, NW, Washington, D.C., 20001. The featured story ... reach authors by registering (free) for the meeting to ... schedule media interviews anytime during the meeting. , ...
... to increase in Hawaii,s mountains, deadly non-native bird ... invading most of the last disease-free refuges for ... birds. A just-published U.S. Geological Survey ... "disease invasion" by examining the present altitudinal range ...
Cached Biology News:Did the North Atlantic fisheries collapse due to fisheries-induced evolution? 2Society for Prevention Research Meeting in Washington, D.C., May 27-29, 2009 2Society for Prevention Research Meeting in Washington, D.C., May 27-29, 2009 3Jeepers creepers: Climate change threatens endangered honeycreepers 2Jeepers creepers: Climate change threatens endangered honeycreepers 3
(Date:11/26/2014)... On January, 14, 2015, UMBC’s ... D.C. science community to the UMBC campus for a ... the Protein Society, will take place from 9 a.m. ... Through discussion, presentations and workshops, the free symposium ... their role in the industry and the future of ...
(Date:11/26/2014)... PMG Research, Inc. announced today ... a network of sites that provide clinical research services to ... patient lives through its partnerships with large physician practices and ... site locations in the Southeastern United States and spans over ... board will be held by: Dr. Robert Holmes, ...
(Date:11/26/2014)... NC (PRWEB) November 25, 2014 ... Intensity Focused Ultrasound (HIFU) devices, recently participated in ... Small Renal Mass 360° .” Key opinion leaders ... therapeutic advances related to small renal masses while ... about different ablative technologies in hands-on labs. Attendees ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 Continuing its ... products, earned three prestigious MarCom Awards for outstanding creative ... received a Platinum MarCom Award, the organization’s top honor, ... in St. Louis held in April of this year. ... than 14,000 attendees. Additionally, Nerium was awarded a Gold ...
Breaking Biology Technology:PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2
... OMAHA, Neb., March 14 Creighton University,law, science, ... taste,of what it takes to convert scientific research ... selected through a competitive application and,interview process -- ... for the,first time on Feb. 13. A three-year, ...
... March 14 Wyeth (NYSE: WYE ),announced today ... Annual,Global Healthcare Conference on Wednesday, March 19, 2008 at ... M. Mahady, Senior Vice,President, Wyeth and President, Wyeth Pharmaceuticals., ... at, http://www.wyeth.com and available for replay following the ...
... March 14 Diamyd Medical AB,( http://www.omxgroup.com, ticker: ... given Diamyd Medical permission to start a Phase III,clinical ... with the therapeutic,diabetes vaccine Diamyd(R)., (Logo: http://www.newscom.com/cgi-bin/prnh/20080314/297194 ... study and to be able to offer this,promising drug ...
Cached Biology Technology:NSF Funds New Entrepreneurship Program 2Wyeth to Present at the Lehman Brothers Eleventh Annual Global Healthcare Conference 2Diamyd Gets Authorization to Begin Phase III Study in the US 2